DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7568 and fbxw7

DIOPT Version :9

Sequence 1:	NP_001263071.1	Gene:	CG7568 / 43482	FlyBaseID:	FBgn0039673	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	XP_009289569.3	Gene:	fbxw7 / 564991	ZFINID:	ZDB-GENE-090313-79	Length:	835	Species:	Danio rerio

Alignment Length:	369	Identity:	90/369 - (24%)
Similarity:	161/369 - (43%)	Gaps:	88/369 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 REPVKKKFYLHKCHNSHILPLTNVSFDRSGERCLTGSYDRTCHVINTQTAQVEHILSGHDNVVFS 165
            |..:|....:.|.|:.|:  :|.:.|  .|.|.::||.|.|..|.:..|.:....|.||...|:|
Zfish   494 RGDLKSPKVVLKGHDDHV--ITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWS 554

  Fly   166 VGFNFPHWLVYLQSGGSGNNLTTFSIIFSDKIVTGSFDGTAKVWSATSGQSLCTFYGHTAELVAA 230
                                    |.:..:.|::||.|.|.|||:|.:|:.:.|.||||:.:...
Zfish   555 ------------------------SQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCM 595

  Fly   231 EFHPVDGKSIATASLDGSARIYDVETSHELQQLTHHGAEVIAARFNRDGQMLLTGSFDHSAAIWD 295
            ..|.   |.:.:.|.|.:.|::|:||...|..|..|.|.|...::  ||:.:::|::|....:||
Zfish   596 HLHE---KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWD 655

  Fly   296 VRSKSLGHQLRGHSAELSNCVWN--FSGSLIATGSLDNTARIWDTRKLDQELYLAARHSDEVLDV 358
            ..:::..|.|:||    :|.|::  |.|..:.:||||.:.|:||..
Zfish   656 PETETCLHTLQGH----TNRVYSLQFDGIHVVSGSLDTSIRVWDVE------------------- 697

  Fly   359 SFDAAGQLLATCSSDCTARVWRLEGSSELEMLSLMAGHSDEVSKVCFSPSGCMLLTASADNTARL 423
                        :.:|               :..:.||....|.:....:  :|::.:||:|.::
Zfish   698 ------------TGNC---------------IHTLTGHQSLTSGMELKDN--ILVSGNADSTVKI 733

  Fly   424 WLTESGQCSQVLAG-HEGEVFSCAYSYAGDAILTASKDNSCRFW 466
            |..::|||.|.|.| |:.:.......:..:.::|:|.|.:.:.|
Zfish   734 WDIKTGQCLQTLQGPHKHQSAVTCLQFNKNFVITSSDDGTVKLW 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7568	NP_001263071.1	WD40	93..466	CDD:225201	89/367 (24%)
		WD40 repeat	122..158	CDD:293791	11/35 (31%)
		WD40	154..467	CDD:238121	75/316 (24%)
		WD40 repeat	189..222	CDD:293791	12/32 (38%)
		WD40 repeat	228..265	CDD:293791	10/36 (28%)
		WD40 repeat	270..306	CDD:293791	8/35 (23%)
		WD40 repeat	314..348	CDD:293791	11/35 (31%)
		WD40 repeat	355..393	CDD:293791	1/37 (3%)
		WD40 repeat	400..436	CDD:293791	10/35 (29%)
		WD40 repeat	442..466	CDD:293791	3/23 (13%)
fbxw7	XP_009289569.3	F-box-like	408..452	CDD:315592
		WD40	503..778	CDD:238121	88/360 (24%)
		WD40 repeat	512..547	CDD:293791	11/36 (31%)
		WD40 repeat	553..587	CDD:293791	13/57 (23%)
		WD40 repeat	592..626	CDD:293791	9/36 (25%)
		WD40 repeat	633..666	CDD:293791	7/34 (21%)
		WD40 repeat	672..706	CDD:293791	11/79 (14%)
		WD40 repeat	714..746	CDD:293791	9/33 (27%)
		WD40 repeat	755..777	CDD:293791	3/21 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R947
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030