DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7568 and slmb

DIOPT Version :9

Sequence 1:	NP_001263071.1	Gene:	CG7568 / 43482	FlyBaseID:	FBgn0039673	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_001262802.1	Gene:	slmb / 42504	FlyBaseID:	FBgn0283468	Length:	597	Species:	Drosophila melanogaster

Alignment Length:	289	Identity:	81/289 - (28%)
Similarity:	125/289 - (43%)	Gaps:	61/289 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 SGNNLTTFSIIFSD-KIVTGSFDGTAKVWSATSGQSLCTFYGHTAELVAAEFHPVDGKSIATASL 245
            |.|:...:.:.:.| |||:|..|.|.|:|..|..|.:.|..|||..::..::   |.|.|.:.|.
  Fly   207 SENSKGVYCLQYDDGKIVSGLRDNTIKIWDRTDLQCVKTLMGHTGSVLCLQY---DDKVIISGSS 268

  Fly   246 DGSARIYDVETSHELQQLTHHGAEVIAARFNRDGQMLLTGSFDHSAAIWDVRSKS---LGHQLRG 307
            |.:.|::||.|...:..|.||...|:..|||..  |::|.|.|.|.|:||:.|.|   |...|.|
  Fly   269 DSTVRVWDVNTGEMVNTLIHHCEAVLHLRFNNG--MMVTCSKDRSIAVWDMTSPSEITLRRVLVG 331

  Fly   308 HSAELSNCVWNFSGSLIATGSLDNTARIWDTRKLDQELYLAARHSDEVLDVSFDAAGQLLATCSS 372
            |.|.::  |.:|....|.:.|.|.|.::|.|                                 |
  Fly   332 HRAAVN--VVDFDEKYIVSASGDRTIKVWST---------------------------------S 361

  Fly   373 DCTARVWRLEGSSELEMLSLMAGHSDEVSKVCFSPSGCMLLTASADNTARLWLTESGQCSQVLAG 437
            .|             |.:..:.||...::  |......::::.|:||:.|||..|.|.|.:||.|
  Fly   362 SC-------------EFVRTLNGHKRGIA--CLQYRDRLVVSGSSDNSIRLWDIECGACLRVLEG 411

  Fly   438 HEGEVFSCAYSYAGDAILTASKDNSCRFW 466
            || |:..| ..:....|::.:.|...:.|
  Fly   412 HE-ELVRC-IRFDTKRIVSGAYDGKIKVW 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7568	NP_001263071.1	WD40	93..466	CDD:225201	80/287 (28%)
		WD40 repeat	122..158	CDD:293791
		WD40	154..467	CDD:238121	81/289 (28%)
		WD40 repeat	189..222	CDD:293791	12/33 (36%)
		WD40 repeat	228..265	CDD:293791	10/36 (28%)
		WD40 repeat	270..306	CDD:293791	15/38 (39%)
		WD40 repeat	314..348	CDD:293791	8/33 (24%)
		WD40 repeat	355..393	CDD:293791	3/37 (8%)
		WD40 repeat	400..436	CDD:293791	11/35 (31%)
		WD40 repeat	442..466	CDD:293791	3/23 (13%)
slmb	NP_001262802.1	Beta-TrCP_D	47..85	CDD:288940
		F-box-like	89..136	CDD:289689
		WD40	<192..495	CDD:225201	81/289 (28%)
		WD40	210..488	CDD:238121	79/286 (28%)
		WD40 repeat	213..248	CDD:293791	12/34 (35%)
		WD40 repeat	254..288	CDD:293791	10/36 (28%)
		WD40 repeat	293..330	CDD:293791	15/38 (39%)
		WD40 repeat	337..370	CDD:293791	11/80 (14%)
		WD40 repeat	376..410	CDD:293791	11/35 (31%)
		WD40 repeat	416..459	CDD:293791	4/24 (17%)
		WD40 repeat	465..487	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR44156
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R947
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.130