DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7568 and fbxw11b

DIOPT Version :9

Sequence 1:	NP_001263071.1	Gene:	CG7568 / 43482	FlyBaseID:	FBgn0039673	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_998669.2	Gene:	fbxw11b / 406825	ZFINID:	ZDB-GENE-040426-2903	Length:	531	Species:	Danio rerio

Alignment Length:	289	Identity:	76/289 - (26%)
Similarity:	124/289 - (42%)	Gaps:	61/289 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 SGNNLTTFSIIFSD-KIVTGSFDGTAKVWSATSGQSLCTFYGHTAELVAAEFHPVDGKSIATASL 245
            |.|:...:.:.:.| ||::|..|.:.|:|...:.:.|....|||..::..::   |.:.|.|.|.
Zfish   226 SENSKGVYCLQYDDEKIISGLRDNSIKIWDKQTLECLKILTGHTGSVLCLQY---DERVIVTGSS 287

  Fly   246 DGSARIYDVETSHELQQLTHHGAEVIAARFNRDGQMLLTGSFDHSAAIWDVRSK---SLGHQLRG 307
            |.:.|::||.:...|..|.||...|:..||...  :::|.|.|.|.|:||:.|.   ||...|.|
Zfish   288 DSTVRVWDVNSGEVLNTLIHHNEAVLHLRFCNG--LMVTCSKDRSIAVWDMASPTDISLRRVLVG 350

  Fly   308 HSAELSNCVWNFSGSLIATGSLDNTARIWDTRKLDQELYLAARHSDEVLDVSFDAAGQLLATCSS 372
            |.|.::  |.:|....|.:.|.|.|.::|.|                             :||
Zfish   351 HRAAVN--VVDFDDKYIVSASGDRTIKVWST-----------------------------STC-- 382

  Fly   373 DCTARVWRLEGSSELEMLSLMAGHSDEVSKVCFSPSGCMLLTASADNTARLWLTESGQCSQVLAG 437
                           |.:..:.||...::  |......::::.|:|||.|||..|.|.|.:||.|
Zfish   383 ---------------EFVRTLNGHKRGIA--CLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEG 430

  Fly   438 HEGEVFSCAYSYAGDAILTASKDNSCRFW 466
            || |:..| ..:....|::.:.|...:.|
Zfish   431 HE-ELVRC-IRFDNKRIVSGAYDGKIKVW 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7568	NP_001263071.1	WD40	93..466	CDD:225201	75/287 (26%)
		WD40 repeat	122..158	CDD:293791
		WD40	154..467	CDD:238121	76/289 (26%)
		WD40 repeat	189..222	CDD:293791	8/33 (24%)
		WD40 repeat	228..265	CDD:293791	10/36 (28%)
		WD40 repeat	270..306	CDD:293791	13/38 (34%)
		WD40 repeat	314..348	CDD:293791	8/33 (24%)
		WD40 repeat	355..393	CDD:293791	3/37 (8%)
		WD40 repeat	400..436	CDD:293791	12/35 (34%)
		WD40 repeat	442..466	CDD:293791	3/23 (13%)
fbxw11b	NP_998669.2	Beta-TrCP_D	67..105	CDD:288940
		F-box-like	109..156	CDD:289689
		WD40	<216..510	CDD:225201	76/289 (26%)
		WD40	229..507	CDD:238121	74/286 (26%)
		WD40 repeat	232..267	CDD:293791	8/34 (24%)
		WD40 repeat	273..307	CDD:293791	10/36 (28%)
		WD40 repeat	312..349	CDD:293791	13/38 (34%)
		WD40 repeat	356..389	CDD:293791	11/80 (14%)
		WD40 repeat	395..429	CDD:293791	12/35 (34%)
		WD40 repeat	435..478	CDD:293791	4/24 (17%)
		WD40 repeat	484..506	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R947
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030