DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG7568 and ago

DIOPT Version :9

Sequence 1:NP_001263071.1 Gene:CG7568 / 43482 FlyBaseID:FBgn0039673 Length:482 Species:Drosophila melanogaster
Sequence 2:NP_523922.1 Gene:ago / 38516 FlyBaseID:FBgn0041171 Length:1326 Species:Drosophila melanogaster


Alignment Length:380 Identity:104/380 - (27%)
Similarity:174/380 - (45%) Gaps:53/380 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 QTLAEAEEEQSPADLEKSPPPRPVSGSVARSQNAFSALKQALEKLQKKLREPVKKKFYLHKCHNS 116
            |.|||...::.....:.:.||      :|....| :.::|.:.::..:.| ||:|...| |.|:.
  Fly   940 QILAEPRSDRPKRGRDGNMPP------IASPWKA-AYMRQHIIEMNWRSR-PVRKPKVL-KGHDD 995

  Fly   117 HILPLTNVSFDRSGERCLTGSYDRTCHVINTQTAQVEHILSGHDNVVFSVGFNFPHWLVYLQSGG 181
            |:  :|.:.|  ||.|.::||.|.|..|.:....:....|.||...|:|             |..
  Fly   996 HV--ITCLQF--SGNRIVSGSDDNTLKVWSAVNGKCLRTLVGHTGGVWS-------------SQM 1043

  Fly   182 SGNNLTTFSIIFSDKIVTGSFDGTAKVWSATSGQSLCTFYGHTAELVAAEFHPVDGKSIATASLD 246
            |||           .|::||.|.|.|||...||..:.|..|||:.:.....|   |..:.:.|.|
  Fly  1044 SGN-----------IIISGSTDRTLKVWDMDSGACVHTLQGHTSTVRCMHLH---GSKVVSGSRD 1094

  Fly   247 GSARIYDVETSHELQQLTHHGAEVIAARFNRDGQMLLTGSFDHSAAIWDVRSKSLGHQLRGHSAE 311
            .:.|::|:|....|..|..|.|.|...::  ||:::::|::|:...||....:...|.|:||   
  Fly  1095 ATLRVWDIEQGSCLHVLVGHLAAVRCVQY--DGKLIVSGAYDYMVKIWHPERQECLHTLQGH--- 1154

  Fly   312 LSNCVWN--FSGSLIATGSLDNTARIWDTRKLDQELYLAARHSDEVLDVSFDAAGQLLATCSSDC 374
             :|.|::  |.|..:.:||||.:.|:||....:.:..|....|   |....:....:|.:.::|.
  Fly  1155 -TNRVYSLQFDGLHVVSGSLDTSIRVWDVETGNCKHTLMGHQS---LTSGMELRQNILVSGNADS 1215

  Fly   375 TARVWRLEGSSELEMLSLMAGHSDEVSKVCFSPSGCMLLTASADNTARLWLTESG 429
            |.:||.:.....|:.||....|...|:  |...:...::|:|.|.|.:||..::|
  Fly  1216 TVKVWDITTGQCLQTLSGPNKHHSAVT--CLQFNSRFVVTSSDDGTVKLWDVKTG 1268

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7568NP_001263071.1 WD40 93..466 CDD:225201 95/339 (28%)
WD40 repeat 122..158 CDD:293791 11/35 (31%)
WD40 154..467 CDD:238121 77/278 (28%)
WD40 repeat 189..222 CDD:293791 11/32 (34%)
WD40 repeat 228..265 CDD:293791 9/36 (25%)
WD40 repeat 270..306 CDD:293791 8/35 (23%)
WD40 repeat 314..348 CDD:293791 11/35 (31%)
WD40 repeat 355..393 CDD:293791 9/37 (24%)
WD40 repeat 400..436 CDD:293791 9/30 (30%)
WD40 repeat 442..466 CDD:293791
agoNP_523922.1 F-box-like 892..938 CDD:289689
WD40 <981..1274 CDD:225201 95/332 (29%)
WD40 988..1264 CDD:238121 89/318 (28%)
WD40 repeat 998..1033 CDD:293791 11/36 (31%)
WD40 repeat 1039..1073 CDD:293791 16/57 (28%)
WD40 repeat 1078..1112 CDD:293791 8/36 (22%)
WD40 repeat 1119..1152 CDD:293791 7/34 (21%)
WD40 repeat 1158..1192 CDD:293791 10/33 (30%)
WD40 repeat 1200..1232 CDD:293791 6/31 (19%)
WD40 repeat 1241..1263 CDD:293791 6/23 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R947
SonicParanoid 00.000 Not matched by this tool.
11.030

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