DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7568 and Wdr88

DIOPT Version :9

Sequence 1:	NP_001263071.1	Gene:	CG7568 / 43482	FlyBaseID:	FBgn0039673	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	XP_036009101.1	Gene:	Wdr88 / 384605	MGIID:	2686275	Length:	667	Species:	Mus musculus

Alignment Length:	446	Identity:	104/446 - (23%)
Similarity:	169/446 - (37%)	Gaps:	83/446 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LDSKTNIEP-----LADRILLQ-TLAEAEEEQSPADLEK-------SPPPRPVSGSVARSQNAFS 87
            :|||....|     ..||.:.| |...|::.:.|..|.:       |.|      .:.|..|..|
Mouse   188 VDSKNRFSPKKMDFSEDREISQPTFLRAQQSKVPWALMRALGLFKLSLP------DIRRYYNLTS 246

  Fly    88 ALKQALEK---LQKKLREPVKKKFYLHKCHNSHILPLTNVSFDRSGERCLTGSYDRTCHVINTQT 149
            ....||:|   .::|......|||:      .:..||:.:.:
Mouse   247 HDPLALDKDRQPREKSHMATVKKFW------GNQQPLSKIPY----------------------- 282

  Fly   150 AQVEHILSGHDNVVFSVGFNFPHWLVYLQSGGSGNNLTTFSIIFSDKIVTGSFDGTAKVWSATSG 214
                .||.|||::|.|..|..              |.|.|        ::.|:|.:.|:|.|..|
Mouse   283 ----KILIGHDHIVSSCHFCM--------------NDTRF--------LSSSYDCSVKLWDAEDG 321

  Fly   215 QSLCTFYGHTAELVAAEFHPVDGKSIATASLDGSARIYDVETSHELQQLTHHGAEVIAARFNRDG 279
            ..:..|.......|.......|.:.|..:|.|.:.|.:||||...|.:: .|...|:..:|:.:|
Mouse   322 TVIWDFEPRPKAPVLECSITADNRRIVASSYDKTVRAWDVETGQLLWKV-RHDTFVVCCKFSPNG 385

  Fly   280 QMLLTG-SFDHSAAIWDVRS-KSLGHQLRGHSAELSNCVWNFSGSLIATGSLDNTARIWDTRKLD 342
            :.:|:. ..|....:.|..: .::.|....|...:::|.::.....:|:.|:|...:|||.....
Mouse   386 KFVLSALDVDRGIYLMDPENITTVIHMKDHHQRSITSCCFDPDSQKVASVSMDRCIKIWDITSRT 450

  Fly   343 QELYLAARHSDEVLDVSFDAAGQLLATCSSDCTARVWRL---EGSSELEMLSLMAGHSDEVSKVC 404
            ....:...|.:.:.|..|.:.|..|.|.|.|...::|.:   |..:....::||.||...||..|
Mouse   451 TLFTIPKAHYNAISDCCFTSTGHFLCTSSWDKNIKIWNVHTGEFRNRGACVTLMKGHEGCVSSCC 515

  Fly   405 FSPSGCMLLTASADNTARLWLTESGQCSQVLAGHEGEVFSCAYSYAGDAILTASKD 460
            .:.....|::...|.|..:|....|.....|.|||..|...|.|.....||:|||:
Mouse   516 IARDSSFLISGGFDKTVAIWDVGGGYRKLALKGHEDWVTDVAISNNKKWILSASKE 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7568	NP_001263071.1	WD40	93..466	CDD:225201	87/376 (23%)
		WD40 repeat	122..158	CDD:293791	2/35 (6%)
		WD40	154..467	CDD:238121	79/312 (25%)
		WD40 repeat	189..222	CDD:293791	8/32 (25%)
		WD40 repeat	228..265	CDD:293791	11/36 (31%)
		WD40 repeat	270..306	CDD:293791	7/37 (19%)
		WD40 repeat	314..348	CDD:293791	7/33 (21%)
		WD40 repeat	355..393	CDD:293791	9/40 (23%)
		WD40 repeat	400..436	CDD:293791	8/35 (23%)
		WD40 repeat	442..466	CDD:293791	8/19 (42%)
Wdr88	XP_036009101.1	WD40	281..569	CDD:238121	76/337 (23%)
		WD40 repeat	292..330	CDD:293791	13/59 (22%)
		WD40 repeat	336..371	CDD:293791	10/35 (29%)
		WD40 repeat	376..413	CDD:293791	7/36 (19%)
		WD40 repeat	421..456	CDD:293791	7/34 (21%)
		WD40 repeat	463..505	CDD:293791	10/41 (24%)
		WD40 repeat	511..537	CDD:293791	7/25 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D872177at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010