DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7568 and fbxw11a

DIOPT Version :9

Sequence 1:	NP_001263071.1	Gene:	CG7568 / 43482	FlyBaseID:	FBgn0039673	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	XP_005173126.1	Gene:	fbxw11a / 334373	ZFINID:	ZDB-GENE-030131-6305	Length:	562	Species:	Danio rerio

Alignment Length:	275	Identity:	75/275 - (27%)
Similarity:	118/275 - (42%)	Gaps:	60/275 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 DKIVTGSFDGTAKVWSATSGQSLCTFYGHTAELVAAEFHPVDGKSIATASLDGSARIYDVETSHE 259
            |||::|..|.:.|:|...|.:.|....|||..::..::   |.:.|.|.|.|.:.|::||.:...
Zfish   271 DKIISGLRDNSIKIWDKQSLECLKVLTGHTGSVLCLQY---DERVIVTGSSDSTVRVWDVSSGEV 332

  Fly   260 LQQLTHHGAEVIAARFNRDGQMLLTGSFDHSAAIWDVRSK---SLGHQLRGHSAELSNCVWNFSG 321
            |..|.||...|:..||...  :::|.|.|.|.|:||:.|.   ||...|.||.|.::  |.:|..
Zfish   333 LNTLIHHNEAVLHLRFCNG--LMVTCSKDRSIAVWDMASATDISLRRVLVGHRAAVN--VVDFDD 393

  Fly   322 SLIATGSLDNTARIWDTRKLDQELYLAARHSDEVLDVSFDAAGQLLATCSSDCTARVWRLEGSSE 386
            ..|.:.|.|.|.::|.|                             :||
Zfish   394 KYIVSASGDRTIKVWST-----------------------------STC---------------- 413

  Fly   387 LEMLSLMAGHSDEVSKVCFSPSGCMLLTASADNTARLWLTESGQCSQVLAGHEGEVFSCAYSYAG 451
             |.:..:.||...::  |......::::.|:|||.|||..|.|.|.:||.||| |:..| ..:..
Zfish   414 -EFVRTLNGHKRGIA--CLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHE-ELVRC-IRFDN 473

  Fly   452 DAILTASKDNSCRFW 466
            ..|::.:.|...:.|
Zfish   474 KRIVSGAYDGKIKVW 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7568	NP_001263071.1	WD40	93..466	CDD:225201	74/273 (27%)
		WD40 repeat	122..158	CDD:293791
		WD40	154..467	CDD:238121	75/275 (27%)
		WD40 repeat	189..222	CDD:293791	9/26 (35%)
		WD40 repeat	228..265	CDD:293791	10/36 (28%)
		WD40 repeat	270..306	CDD:293791	13/38 (34%)
		WD40 repeat	314..348	CDD:293791	8/33 (24%)
		WD40 repeat	355..393	CDD:293791	3/37 (8%)
		WD40 repeat	400..436	CDD:293791	12/35 (34%)
		WD40 repeat	442..466	CDD:293791	3/23 (13%)
fbxw11a	XP_005173126.1	Beta-TrCP_D	98..136	CDD:288940
		F-box-like	140..187	CDD:289689
		WD40	<247..541	CDD:225201	75/275 (27%)
		WD40	260..538	CDD:238121	75/275 (27%)
		WD40 repeat	263..298	CDD:293791	9/26 (35%)
		WD40 repeat	304..338	CDD:293791	10/36 (28%)
		WD40 repeat	343..380	CDD:293791	13/38 (34%)
		WD40 repeat	387..420	CDD:293791	11/80 (14%)
		WD40 repeat	426..460	CDD:293791	12/35 (34%)
		WD40 repeat	466..509	CDD:293791	4/24 (17%)
		WD40 repeat	515..537	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R947
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030