DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7568 and pop2

DIOPT Version :9

Sequence 1:	NP_001263071.1	Gene:	CG7568 / 43482	FlyBaseID:	FBgn0039673	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_594956.1	Gene:	pop2 / 2543514	PomBaseID:	SPAC4D7.03	Length:	703	Species:	Schizosaccharomyces pombe

Alignment Length:	537	Identity:	112/537 - (20%)
Similarity:	208/537 - (38%)	Gaps:	149/537 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 YPPGLAVNYKTT--KGNERLRHFDLLDLDSKTNIEPLADRILLQTLAEAEEEQSPADLEKSPPPR 73
            :||...|:...|  .|::.:.. ||.||:.::         ::||.     |..|..::
pombe   164 FPPSPKVDTSNTVSPGSKPISE-DLEDLNLQS---------IVQTF-----EDLPEGIQ------ 207

  Fly    74 PVSGSVARSQNAFSALKQALEKLQKKLREPVKKKFYLHKCH----NSHILPLTNVSFDRSGERCL 134
                |.|..|...|..:|::..|..:. ||:.||..|....    .|.:|.|...||  ...|.:
pombe   208 ----SYAFFQLLRSCNRQSMRLLLNEC-EPLLKKDILSNLPFSIVQSILLNLDIHSF--LSCRLV 265

  Fly   135 TGSYDRTCHVINTQTAQVEHILS------------------------GHDNV-------VFSVGF 168
            :.:::|   :::..|:..:|:.|                        .:|.:       :|...|
pombe   266 SPTWNR---ILDVHTSYWKHMFSLFGFQINENDWKYANPNLNRPPFLHNDQISDDYFPEIFKRHF 327

  Fly   169 -NFPHWL------------VYLQSGGSGNNLTTFSIIFSDKIVTGSFDGTAKVWSATSGQSLCTF 220
             |...||            :::.     |.:.|..::..|:|:|.|..||.::.:|.:|......
pombe   328 LNRKRWLFPSIPPSHLSFPIHVP-----NFMITSLLLHKDRIITTSGSGTIQIHNAITGVLEARL 387

  Fly   221 YGHTAELVAAEFHPVDGKSIATASLDGSARIYDVETSH---------------EL---QQLTHHG 267
            .||...:.|.:.|.   .::.:.|:|.:.|::::|.:.               |:   .:|..||
pombe   388 EGHKEGVWAVKIHE---NTLVSGSIDKTVRVWNIEKAKCTHIFRGHISIIRCLEILVPSRLIRHG 449

  Fly   268 AEVIAARFNRDGQMLLTGSFDHSAAIWDVRSKSLGHQLRGHSAELSNCVWNFSGSLIATGSLDNT 332
            .|::    ..|...:::||.||:..:|.:...:....|..:                 |.|:|.
pombe   450 VEIV----EPDQPYIVSGSRDHTLRVWKLPKNTDPPYLPDN-----------------TNSIDR- 492

  Fly   333 ARIWDTRKLDQELYLAARHSDEVLDVSFDAAGQLLATCSSDCTARVWRLEGSSELEMLSLMAGHS 397
               |:  |....::....|:|.|..:|  ..|.:|.:.|.|.:.|:||:   |..|.|..:.|||
pombe   493 ---WE--KNPYFVHTLIGHTDSVRTIS--GYGDILVSGSYDSSIRIWRV---STGECLYHLRGHS 547

  Fly   398 DEVSKVCFSPSGCMLLTASADNTARLWLTESGQCSQVLAGHEGEVFSCAYSYAGDAILTASKDNS 462
            ..:..|.:.|...:.::.|.|.:.|:|...:|.|..||.||  :.|....:...:.:::.|.|::
pombe   548 LRIYSVLYEPERNICISGSMDKSIRVWDLSTGTCKYVLEGH--DAFVTLLNVFQNRLISGSADST 610

  Fly   463 CRFWRXYDWYTVQLNDG 479
            .|.|        .||.|
pombe   611 IRIW--------DLNTG 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7568	NP_001263071.1	WD40	93..466	CDD:225201	90/438 (21%)
		WD40 repeat	122..158	CDD:293791	7/59 (12%)
		WD40	154..467	CDD:238121	76/374 (20%)
		WD40 repeat	189..222	CDD:293791	8/32 (25%)
		WD40 repeat	228..265	CDD:293791	8/54 (15%)
		WD40 repeat	270..306	CDD:293791	6/35 (17%)
		WD40 repeat	314..348	CDD:293791	5/33 (15%)
		WD40 repeat	355..393	CDD:293791	12/37 (32%)
		WD40 repeat	400..436	CDD:293791	9/35 (26%)
		WD40 repeat	442..466	CDD:293791	4/23 (17%)
pop2	NP_594956.1	WD40	219..657	CDD:225201	95/457 (21%)
		FBOX	242..282	CDD:197608	8/44 (18%)
		WD40	360..654	CDD:238121	70/305 (23%)
		WD40 repeat	395..429	CDD:293791	6/36 (17%)
		WD40 repeat	434..504	CDD:293791	17/96 (18%)
		WD40 repeat	509..544	CDD:293791	12/39 (31%)
		WD40 repeat	550..586	CDD:293791	9/35 (26%)
		WD40 repeat	630..653	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R947
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030