DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7568 and pof1

DIOPT Version :9

Sequence 1:	NP_001263071.1	Gene:	CG7568 / 43482	FlyBaseID:	FBgn0039673	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_593310.1	Gene:	pof1 / 2542914	PomBaseID:	SPAC57A10.05c	Length:	605	Species:	Schizosaccharomyces pombe

Alignment Length:	414	Identity:	91/414 - (21%)
Similarity:	163/414 - (39%)	Gaps:	81/414 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SKTNIEPLADRILLQTLAEAEEEQSP---ADLEKSPPPRPVSGSVARSQNAFSALKQALEKLQKK 99
            :|.:|:...:|:..:.:.:| .|.||   |.|:..|        .:.::...|::|........|
pombe   180 AKASIQKRYERLTKRGVDQA-HESSPVKKAKLDDYP--------TSSNEETISSVKPPSPNSDSK 235

  Fly   100 LREPVK----KKFYLHKCH----------NSHILPLTNVSFDRSGERCL--------TGSYDRTC 142
            ...|.|    |:.|..:|.          ...:|     |....|..||        :||||.|.
pombe   236 FFLPFKTRPWKEVYAERCRVECNWRHGRCRQVVL-----SGHSDGVMCLQLVRNILASGSYDATI 295

  Fly   143 HVINTQTAQVEHILSGHDNVVFSVGFNFPHWLVYLQSGGSGNNLTTFSIIFSDKIVTGSFDGTAK 207
            .:.|..|.|...:|.||.:.|..:.|:                        ..|:::||.|.|.:
pombe   296 RLWNLATFQQVALLEGHSSGVTCLQFD------------------------QCKLISGSMDKTIR 336

  Fly   208 VWSATSGQSLCTFYGHTAELVAAEFHPVDGKSIATASLDGSARIYDVETSHELQQLTHHGAEVIA 272
            :|:..:.:.:...:|||..::...|   |...:.:.|.|.:.:::.......: .|..|...|.:
pombe   337 IWNYRTSECISILHGHTDSVLCLTF---DSTLLVSGSADCTVKLWHFSGGKRI-TLRGHTGPVNS 397

  Fly   273 ARFNRDGQMLLTGSFDHSAAIWDVRSKSLGHQLRGHSAELSNCVWNFSGSLIATGSLDNTARIWD 337
            .|..||..::|:||.|.:..||.:.:.:..|....|...:.:..  .:.|.:.:.|||.|.:.||
pombe   398 VRIIRDRGLVLSGSDDSTIKIWSLETNTCLHTFSAHIGPVQSLA--LADSRLFSCSLDGTIKQWD 460

  Fly   338 TRKLDQELYLAARHSDEVLDVSFDAAGQL-LATCSSDCTARVWRLEGSSELEMLSLMAGHSDEVS 401
            ..| .:.::....|.:.|.::   ||..| |.:.:.|...:||     ...|.:..:..||:.|:
pombe   461 IEK-KKCVHTLFGHIEGVWEI---AADHLRLISGAHDGVVKVW-----EACECVHTLKNHSEPVT 516

  Fly   402 KVCFSPSGCMLLTASADNTARLWL 425
            .|..  ..|.:::.|.|....|||
pombe   517 SVAL--GDCEVVSGSEDGKIYLWL 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7568	NP_001263071.1	WD40	93..466	CDD:225201	79/356 (22%)
		WD40 repeat	122..158	CDD:293791	13/43 (30%)
		WD40	154..467	CDD:238121	60/273 (22%)
		WD40 repeat	189..222	CDD:293791	6/32 (19%)
		WD40 repeat	228..265	CDD:293791	5/36 (14%)
		WD40 repeat	270..306	CDD:293791	11/35 (31%)
		WD40 repeat	314..348	CDD:293791	8/33 (24%)
		WD40 repeat	355..393	CDD:293791	9/38 (24%)
		WD40 repeat	400..436	CDD:293791	8/26 (31%)
		WD40 repeat	442..466	CDD:293791
pof1	NP_593310.1	F-box-like	110..156	CDD:289689
		WD40	<258..564	CDD:225201	73/327 (22%)
		WD40	268..537	CDD:238121	70/314 (22%)
		WD40 repeat	317..351	CDD:293791	7/57 (12%)
		WD40 repeat	356..389	CDD:293791	4/36 (11%)
		WD40 repeat	396..431	CDD:293791	10/34 (29%)
		WD40 repeat	437..471	CDD:293791	8/36 (22%)
		WD40 repeat	477..512	CDD:293791	9/42 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R947
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030