DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7568 and wdr88

DIOPT Version :9

Sequence 1:	NP_001263071.1	Gene:	CG7568 / 43482	FlyBaseID:	FBgn0039673	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	XP_004913613.1	Gene:	wdr88 / 101732918	XenbaseID:	XB-GENE-6044415	Length:	397	Species:	Xenopus tropicalis

Alignment Length:	429	Identity:	94/429 - (21%)
Similarity:	170/429 - (39%)	Gaps:	101/429 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 IEPLADRILLQTLAEAEEEQSPADLEKSPPPRPVSG------SVARSQ---NAFSALKQALE--- 94
            ::|||          .|:|:|.|        :|.||      |...||   ..|...|.|:.
Frog     3 LDPLA----------VEQERSVA--------KPQSGEESLWESERLSQVPYRVFRGHKGAVNSCH 49

  Fly    95 ------KLQKKLREPVKKKFYLHKCHNSHIL------PLTNVSFDRSGERCLTGSYDRTCHVINT 147
                  |:.....:...|.:.:.:|...|:.      |::..:.....:|.:|.|||:|..:.:.
Frog    50 FCFEDTKILSCSHDTTAKLWDVSRCDPVHVFGDEHKAPISECNLTADNKRMVTSSYDKTVKLWDM 114

  Fly   148 QTAQVEHILSGHDNVVFSVGFNFPHWLVYLQSGGSGNNLTTFSIIFSDKIVTGSFDGTAKVW--- 209
            :..|:                   .|.|.|:...:..|:::     ..|:|..:.|....::
Frog   115 ECGQL-------------------IWSVSLEGLVNSCNISS-----DGKLVLCALDMDNSLYIID 155

  Fly   210 SATSGQSLCTFYGHTAELVAAEFHPVDGKSIATASLDGSARIYDVETSHELQQLTHHGAEVIA-A 273
            |||..:.......|.:.:....|.| :.:.:.:.|.|.:.:::|::..|....:.:..:.||: .
Frog   156 SATGSKIAYIKDQHLSTITRCCFDP-EIQRVCSVSSDRTIKLWDIKAQHATIIIRNAHSNVISDC 219

  Fly   274 RFNRDGQMLLTGSFDHSAAIWDVRSKSLGHQL-----RGHSAELSNCVWNFSGSLIATGSLDNTA 333
            ||:.:|.:|.|.|:|....:||:.:....||.     :.|...:|:|.::...|:|.:|..|.|.
Frog   220 RFSSNGHILCTASWDKCLKLWDINAGQFRHQRPDVLHKAHKGSVSSCTFSKDMSVIVSGGYDKTV 284

  Fly   334 RIWDTRKLDQELYLAARHSDEVLDVSFDAAGQLLATCSSDCTARVWRLE---------------G 383
            .:||.....::|.|.. |.|.|||||..|..:.:.:.|.|.|.|:|.:|               |
Frog   285 VLWDVIAASKKLVLKG-HEDWVLDVSLSANKKWIVSSSKDSTLRLWNIENYEKIPAVTENIRALG 348

  Fly   384 SSELEM------LSLMAGHSDEVSKVCFSPSGCMLLTAS 416
            |:.::.      .|.|...:.::.|.|..   |.|.|.|
Frog   349 STVVQCEECKKPFSFMNWDNPDLLKRCVF---CRLATPS 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7568	NP_001263071.1	WD40	93..466	CDD:225201	78/369 (21%)
		WD40 repeat	122..158	CDD:293791	7/35 (20%)
		WD40	154..467	CDD:238121	66/293 (23%)
		WD40 repeat	189..222	CDD:293791	6/35 (17%)
		WD40 repeat	228..265	CDD:293791	6/36 (17%)
		WD40 repeat	270..306	CDD:293791	13/41 (32%)
		WD40 repeat	314..348	CDD:293791	9/33 (27%)
		WD40 repeat	355..393	CDD:293791	15/58 (26%)
		WD40 repeat	400..436	CDD:293791	6/17 (35%)
		WD40 repeat	442..466	CDD:293791
wdr88	XP_004913613.1	WD40	34..330	CDD:238121	69/321 (21%)
		WD40 repeat	47..83	CDD:293791	4/35 (11%)
		WD40 repeat	89..127	CDD:293791	10/56 (18%)
		WD40 repeat	129..166	CDD:293791	7/41 (17%)
		WD40 repeat	174..209	CDD:293791	6/35 (17%)
		WD40 repeat	216..254	CDD:293791	12/37 (32%)
		WD40 repeat	263..289	CDD:293791	8/25 (32%)
		WD40 repeat	305..329	CDD:293791	10/23 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D872177at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010