Protein Alignment alph and PPM1D

DIOPT Version :10

• Sequence 1: NP_651701.1
• Gene: alph / 43481
• FlyBaseID: FBgn0086361
• Length: 374
• Species: Drosophila melanogaster
• Sequence 2: NP_003611.1
• Gene: PPM1D / 8493
• HGNCID: 9277
• Length: 605
• Species: Homo sapiens
• Alignment Length: 303
• Identity: 92/303 - (30%)
• Similarity: 130/303 - (42%)
• Gaps: 74/303 - (24%)

  Fly    48 DALPD----------------WSFFAVFDGHAGCKVSEHCAKHLLESIISTEEFIGGDHVK---G 93
            |.|||                .:||||.|||.|.:.::...:||...|...:.|...:..|   .
Human    77 DPLPDAGASPAPSRCCRRRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAA 141

  Fly    94 IRTGFLRIDEVM----RELPEFTRESEKCGGTTAVCAFVGLTQVYIANCGDSRAVLCRQGVP--- 151
            ||.|||.....|    .|.|:.........||||....:...::|:|:.|||..||..|..|
Human   142 IRKGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKDD 206

  Fly   152 ----VFATQDHKPILPEEKERIYNAGGSVM----IKRV---------NGT------------LAV 187
                |..||||||.||:|:|||...|||||    :.||         ||.            |||
Human   207 FVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTVIDQIPFLAV 271

  Fly   188 SRALGD---YDFKNVKEKGQCEQLVSPEPEIFCQSRQ-DSDEFLVLACDGIWDVMSNEDVCSFI- 247
            :|||||   |||.:      .|.:|||||:....:.. ...::::|..||:|:::..:|..|..
Human   272 ARALGDLWSYDFFS------GEFVVSPEPDTSVHTLDPQKHKYIILGSDGLWNMIPPQDAISMCQ 330

  Fly   248 ---HSRMRVTSNLVSIANQVVDTCLHKGSR-----DNMSIIII 282
               ..:..:..:..|.|..:|:..|.:..:     ||.|.|:|
Human   331 DQEEKKYLMGEHGQSCAKMLVNRALGRWRQRMLRADNTSAIVI 373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alph	NP_651701.1	PP2Cc	24..284	CDD:238083	92/303 (30%)
		PP2C_C	278..355	CDD:429684	3/5 (60%)
PPM1D	NP_003611.1	Interaction with CHEK1. /evidence=ECO:0000269|PubMed:15870257	1..101		4/23 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..90		4/12 (33%)
		PP2C	67..368	CDD:395385	88/296 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	516..591