DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alph and ppm-1.A

DIOPT Version :9

Sequence 1:	NP_651701.1	Gene:	alph / 43481	FlyBaseID:	FBgn0086361	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	NP_001023842.1	Gene:	ppm-1.A / 179469	WormBaseID:	WBGene00006460	Length:	468	Species:	Caenorhabditis elegans

Alignment Length:	365	Identity:	157/365 - (43%)
Similarity:	225/365 - (61%)	Gaps:	32/365 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGGFLDKPKTAKHNDEGEGNKLLFGVSSMQGWRSEMEDAYYARAGLGDALP--DWSFFAVFDGHA 63
            ||.|||||||.|.|..||||.:.:|:|||||||..|||::.|.|.:..:.|  ||||||||||||
Worm    84 MGAFLDKPKTDKTNVHGEGNGIRYGMSSMQGWRICMEDSHIAEAIMSQSSPYKDWSFFAVFDGHA 148

  Fly    64 GCKVSEHCAKHLLESIISTEEF------------IGGDHV-----KGIRTGFLRIDEVMRELPEF 111
            |..::...:..|||.:||:|||            :..|..     |||:.|||..||:.:...:.
Worm   149 GHHIANRASSQLLEHLISSEEFREMTKTLEENNGVLTDSTLKLLEKGIKKGFLSFDEISKTSNDI 213

  Fly   112 TRESEKCGGTTAVCAFVGLTQVYIANCGDSRAVLCRQGVPVFATQDHKPILPEEKERIYNAGGSV 176
            ::     .|.|||||.|..|...|.|.||||||:..:. .:|.|:||||.|.:|::||..|||||
Worm   214 SK-----SGCTAVCAIVTPTHFIIGNLGDSRAVVAGKN-EIFGTEDHKPYLEKERKRIEGAGGSV 272

  Fly   177 MIKRVNGTLAVSRALGDYDFKNVKEKGQCEQLVSPEPEIFCQSRQ-DSDEFLVLACDGIWDVMSN 240
            ||:|:||:||||||.|||::|:.......:|||||||:::.:.|. ::|:|:|:|||||:|||:|
Worm   273 MIQRINGSLAVSRAFGDYEYKDDPRLPADQQLVSPEPDVYIRERNLENDQFMVVACDGIYDVMTN 337

  Fly   241 EDVCSFIHSRMRVTSNLVSIANQVVDTCLHKGSRDNMSIIIIAFPGAPKPTEEAIEAEH----RL 301
            |::..|:..|:.|.|:|..:.:.|:|.||.|||||||:::::.||.||:......|||.    |:
Worm   338 EELAEFVKDRLSVHSDLREVCDDVLDECLVKGSRDNMTMVVVCFPAAPEVNIHRKEAEEAWVSRV 402

  Fly   302 EKQIEKITRDEIESSKITDYVDL--LKCLQNRDDIEGLPP 339
            :..|.:...:.:.:.......|:  ||.:.::....||.|
Worm   403 KTVINQFLDEAVAAEDFKQEEDMVTLKSILDKVTANGLLP 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alph	NP_651701.1	PP2Cc	24..284	CDD:238083	127/279 (46%)
alph	NP_651701.1	PP2C_C	278..352	CDD:285117	15/68 (22%)
ppm-1.A	NP_001023842.1	PP2C	105..374	CDD:366121	125/274 (46%)
ppm-1.A	NP_001023842.1	PP2C_C	375..>412	CDD:392186	9/36 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156327
Domainoid	1	1.000	235	1.000	Domainoid score	I1321
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2027
Inparanoid	1	1.050	281	1.000	Inparanoid score	I1754
Isobase	1	0.950	-	0	Normalized mean entropy	S1497
OMA	1	1.010	-	-		QHG53745
OrthoDB	1	1.010	-	-		D262211at33208
OrthoFinder	1	1.000	-	-		FOG0000692
OrthoInspector	1	1.000	-	-		otm14106
orthoMCL	1	0.900	-	-		OOG6_100270
Panther	1	1.100	-	-	LDO	PTHR47992
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R955
SonicParanoid	1	1.000	-	-		X444
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.890