DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alph and PPM1K

DIOPT Version :9

Sequence 1:	NP_651701.1	Gene:	alph / 43481	FlyBaseID:	FBgn0086361	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	NP_689755.3	Gene:	PPM1K / 152926	HGNCID:	25415	Length:	372	Species:	Homo sapiens

Alignment Length:	292	Identity:	88/292 - (30%)
Similarity:	139/292 - (47%)	Gaps:	48/292 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PKTAKHNDEGEGNKLLFGVSSMQGWRSEMEDAYYARAGLGDALPDWSFFAVFDGHAGCKVSEHCA 72
            ||.:..|         .|.:|..|.|.|.||    |........:..:|||:|||.|...::.|.
Human    88 PKISLEN---------VGCASQIGKRKENED----RFDFAQLTDEVLYFAVYDGHGGPAAADFCH 139

  Fly    73 KHLLESIIS--TEEFIGGDHVKGIRT----GFLRIDEVMRELPEFTRESE-KCGGTTAVCAFV-- 128
            .|:.:.|:.  .:|       |.:.|    .||.||:........:.::. ...||||..|.:
Human   140 THMEKCIMDLLPKE-------KNLETLLTLAFLEIDKAFSSHARLSADATLLTSGTTATVALLRD 197

  Fly   129 GLTQVYIANCGDSRAVLCRQGVPVFATQDHKPILPEEKERIYNAGG-----SVMIKRVNGTLAVS 188
            |: ::.:|:.|||||:|||:|.|:..|.||.|...:|||||...||     |:....|||.||::
Human   198 GI-ELVVASVGDSRAILCRKGKPMKLTIDHTPERKDEKERIKKCGGFVAWNSLGQPHVNGRLAMT 261

  Fly   189 RALGDYDFKNVKEKGQCEQLVSPEPEI-FCQSRQDSDEFLVLACDGIWDVMSNEDVCSFIHSRMR 252
            |::||.|   :|..|     |..|||. ..:.....|.||||..|||..:::::::|.|::.
Human   262 RSIGDLD---LKTSG-----VIAEPETKRIKLHHADDSFLVLTTDGINFMVNSQEICDFVNQ--- 315

  Fly   253 VTSNLVSIANQVVDTCLHKGSRDNMSIIIIAF 284
             ..:....|:.|.:..:..|:.||.:.:::.|
Human   316 -CHDPNEAAHAVTEQAIQYGTEDNSTAVVVPF 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alph	NP_651701.1	PP2Cc	24..284	CDD:238083	84/274 (31%)
alph	NP_651701.1	PP2C_C	278..352	CDD:285117	1/7 (14%)
PPM1K	NP_689755.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..55
PPM1K	NP_689755.3	PP2Cc	95..346	CDD:238083	84/274 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53745
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820