Protein Alignment alph and PPM1K

DIOPT Version :10

• Sequence 1: NP_651701.1
• Gene: alph / 43481
• FlyBaseID: FBgn0086361
• Length: 374
• Species: Drosophila melanogaster
• Sequence 2: NP_689755.3
• Gene: PPM1K / 152926
• HGNCID: 25415
• Length: 372
• Species: Homo sapiens
• Alignment Length: 292
• Identity: 88/292 - (30%)
• Similarity: 139/292 - (47%)
• Gaps: 48/292 - (16%)

  Fly     8 PKTAKHNDEGEGNKLLFGVSSMQGWRSEMEDAYYARAGLGDALPDWSFFAVFDGHAGCKVSEHCA 72
            ||.:..|         .|.:|..|.|.|.||    |........:..:|||:|||.|...::.|.
Human    88 PKISLEN---------VGCASQIGKRKENED----RFDFAQLTDEVLYFAVYDGHGGPAAADFCH 139

  Fly    73 KHLLESIIS--TEEFIGGDHVKGIRT----GFLRIDEVMRELPEFTRESE-KCGGTTAVCAFV-- 128
            .|:.:.|:.  .:|       |.:.|    .||.||:........:.::. ...||||..|.:
Human   140 THMEKCIMDLLPKE-------KNLETLLTLAFLEIDKAFSSHARLSADATLLTSGTTATVALLRD 197

  Fly   129 GLTQVYIANCGDSRAVLCRQGVPVFATQDHKPILPEEKERIYNAGG-----SVMIKRVNGTLAVS 188
            |: ::.:|:.|||||:|||:|.|:..|.||.|...:|||||...||     |:....|||.||::
Human   198 GI-ELVVASVGDSRAILCRKGKPMKLTIDHTPERKDEKERIKKCGGFVAWNSLGQPHVNGRLAMT 261

  Fly   189 RALGDYDFKNVKEKGQCEQLVSPEPEI-FCQSRQDSDEFLVLACDGIWDVMSNEDVCSFIHSRMR 252
            |::||.|   :|..|     |..|||. ..:.....|.||||..|||..:::::::|.|::.
Human   262 RSIGDLD---LKTSG-----VIAEPETKRIKLHHADDSFLVLTTDGINFMVNSQEICDFVNQ--- 315

  Fly   253 VTSNLVSIANQVVDTCLHKGSRDNMSIIIIAF 284
             ..:....|:.|.:..:..|:.||.:.:::.|
Human   316 -CHDPNEAAHAVTEQAIQYGTEDNSTAVVVPF 346

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alph	NP_651701.1	PP2Cc	24..284	CDD:238083	84/274 (31%)
		PP2C_C	278..355	CDD:429684	1/7 (14%)
PPM1K	NP_689755.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..55
		Critical for association with the BCKDH complex. /evidence=ECO:0000269|PubMed:22589535	46..61
		PP2Cc	95..346	CDD:238083	84/274 (31%)