DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alph and TAB1

DIOPT Version :9

Sequence 1:	NP_651701.1	Gene:	alph / 43481	FlyBaseID:	FBgn0086361	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	NP_006107.1	Gene:	TAB1 / 10454	HGNCID:	18157	Length:	504	Species:	Homo sapiens

Alignment Length:	320	Identity:	78/320 - (24%)
Similarity:	133/320 - (41%)	Gaps:	92/320 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 FAVFDGHAGCKVSEHCAKHLLESIISTEEFIG---GDHVKG------------IRTGFLR-IDEV 104
            :.||:|:.|.:|:...|:.|     |.|..:|   .:|.:.            :...||. ||:.
Human    65 YGVFNGYDGNRVTNFVAQRL-----SAELLLGQLNAEHAEADVRRVLLQAFDVVERSFLESIDDA 124

  Fly   105 MRE-------LPE------------------FTRESEKCGGTTAVCAFVGLTQVYIANCGDSRAV 144
            :.|       |||                  .|.|.|..||..||.|.:...::|:||.|.:||:
Human   125 LAEKASLQSQLPEGVPQHQLPPQYQKILERLKTLEREISGGAMAVVAVLLNNKLYVANVGTNRAL 189

  Fly   145 LCRQGVP-VFATQ---DHKPILPEEKERIYNAG-GSVMIKRVNGTLA---VSRALGDYDFK---- 197
            ||:..|. :..||   ||.....:|..|:...| .:..||:| |.:.   .:|.:|||..|
Human   190 LCKSTVDGLQVTQLNVDHTTENEDELFRLSQLGLDAGKIKQV-GIICGQESTRRIGDYKVKYGYT 253

  Fly   198 --NVKEKGQCEQLVSPEPEIF-CQSRQDSDEFLVLACDGIWDVM--------SNEDVCSFIHSRM 251
              ::....:.:.::: ||||. .|.......||||..:|::..:        :|:::.:.|.:..
Human   254 DIDLLSAAKSKPIIA-EPEIHGAQPLDGVTGFLVLMSEGLYKALEAAHGPGQANQEIAAMIDTEF 317

  Fly   252 RVTSNLVSIANQVV--------DTCLHKGSR-------DNMSIIIIAFPGAP-----KPT 291
            ...::|.::|..||        ||....|.|       ::|::::..| |.|     :||
Human   318 AKQTSLDAVAQAVVDRVKRIHSDTFASGGERARFCPRHEDMTLLVRNF-GYPLGEMSQPT 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alph	NP_651701.1	PP2Cc	24..284	CDD:238083	73/306 (24%)
alph	NP_651701.1	PP2C_C	278..352	CDD:285117	5/19 (26%)
TAB1	NP_006107.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		PP2C	69..334	CDD:395385	66/271 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	430..478
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810