Protein Alignment Trc8 and HRD1

DIOPT Version :9

• Sequence 1: NP_996303.1
• Gene: Trc8 / 43476
• FlyBaseID: FBgn0039668
• Length: 809
• Species: Drosophila melanogaster
• Sequence 2: NP_014630.1
• Gene: HRD1 / 854149
• SGDID: S000005373
• Length: 551
• Species: Saccharomyces cerevisiae
• Alignment Length: 484
• Identity: 86/484 - (17%)
• Similarity: 148/484 - (30%)
• Gaps: 168/484 - (34%)

  Fly   363 MTGVISMFCHY---------------IGRGFQ---------------WYLLT---------YDDE 388
            :|.:::.:|.|               :..||.               |.|||         .:.|
Yeast    16 VTYLLTFYCVYSATKTSVSFLQVTLKLNEGFNLMVLSIFILLNSTLLWQLLTKLLFGELRLIEHE 80

  Fly   389 ---EKSLGTVSAVLFYILALQTGLTSLSPDKRFIRLC-RNLCLLMTALLHFLHNIVSPILMSLSA 449
               |:...|:...||        ::||..::.|..:. ..|.||...:.|:   |:...|.:|..
Yeast    81 HIFERLPFTIINTLF--------MSSLFHERYFFTVAFFGLLLLYLKVFHW---ILKDRLEALLQ 134

  Fly   450 ARNPSRKRHVRALSVCAFLVVLSVSLLYHLWSQQSISTWLLAVTAFSVEVVVKVLVSLATYTLFL 514
            :.|.|........|..:|.:||...:.|.:.: :.||: :.......:|.....|:.:..:|:.|
Yeast   135 SINDSTTMKTLIFSRFSFNLVLLAVVDYQIIT-RCISS-IYTNQKSDIESTSLYLIQVMEFTMLL 197

  Fly   515 LDARRQF------FWE------------------------------------------------- 524
            :|....|      |||
Yeast   198 IDLLNLFLQTCLNFWEFYRSQQSLSNENNHIVHGDPTDENTVESDQSQPVLNDDDDDDDDDRQFT 262

  Fly   525 KLDDYLYYVRAFGNSVEFCFGILLFINGAWILIFESAQNATGGGIRAIMMCIHAYFNIWCEARAG 589
            .|:....|.:|......|   :...::.:.::.|.          ..:|:.....::|....::|
Yeast   263 GLEGKFMYEKAIDVFTRF---LKTALHLSMLIPFR----------MPMMLLKDVVWDILALYQSG 314

  Fly   590 WSVFMKRRSAVHKISALPEATPAQLQ--AFDD-VCAICYQEMYSA-------------KITRCRH 638
            .|::...|:.......|...|..|||  |.|| :|.||..|:..:             |...|.|
Yeast   315 TSLWKIWRNNKQLDDTLVTVTVEQLQNSANDDNICIICMDELIHSPNQQTWKNKNKKPKRLPCGH 379

  Fly   639 FFHGVCLRKWLYVQDRCPLCH-------------------EIMMYTDKADEN---------APEA 675
            ..|..||:.|:.....||:|.                   :|...|...|..         |.|.
Yeast   380 ILHLSCLKNWMERSQTCPICRLPVFDEKGNVVQTTFTSNSDITTQTTVTDSTGIATDQQGFANEV 444

  Fly   676 EPAPAAQAEQPMRIYPRDDANNAAAQRRS 704
            :..|.......:||.|..:.:..|.:.||
Yeast   445 DLLPTRTTSPDIRIVPTQNIDTLAMRTRS 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trc8	NP_996303.1	TRC8_N	122..590	CDD:290425	49/324 (15%)
		zf-rbx1	<618..659	CDD:289448	15/54 (28%)
		zf-RING_2	619..659	CDD:290367	14/53 (26%)
HRD1	NP_014630.1	HRD1	5..551	CDD:227568	86/484 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6571
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.930