DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trc8 and SAN1

DIOPT Version :9

Sequence 1:	NP_996303.1	Gene:	Trc8 / 43476	FlyBaseID:	FBgn0039668	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_010427.3	Gene:	SAN1 / 851721	SGDID:	S000002550	Length:	610	Species:	Saccharomyces cerevisiae

Alignment Length:	233	Identity:	45/233 - (19%)
Similarity:	86/233 - (36%)	Gaps:	82/233 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   636 CRHFFHGVCLRKWLYVQDRCPLCHEIM---MYTDKADENAPEAEPAPAAQAEQPMRIYPRDDANN 697
            |.|.|...|:.||..:::.||||.:.:   :...:|.:...:...|..|..|:..|:.....|.|
Yeast   257 CGHIFGRECIYKWSRLENSCPLCRQKISESVGVQRAAQQDTDEVAANEAAFERIRRVLYDPTAVN 321

  Fly   698 AAAQRRSPERAPVEASEQAPATSSSSAAATIGAEAVSAIVESAAAVGEA---------------- 746
            :..:..|   ||.|       .:|::...|||          .|:.||.
Yeast   322 STNENSS---APSE-------NTSNTTVPTIG----------NASSGEQMLSRTGFFLVPQNGQP 366

  Fly   747 -------------RSLVSVASSSSATHRISASGSSDS----------SYMTASAQSPPPTATSAA 788
                         |:.|:..||::.....::.||:::          :.....:.:|.|:|:.::
Yeast   367 LHNPVRLPPNDSDRNGVNGPSSTTQNPPSNSGGSNNNQSPRWVPIPLTLFQFHSPNPNPSASDSS 431

  Fly   789 AVATAA----ASNTT----------------HMFRMSQ 806
            |..:||    ::||:                |:|.::|
Yeast   432 ASPSAANGPNSNNTSSDATDPHHNRLRAVLDHIFNVAQ 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trc8	NP_996303.1	TRC8_N	122..590	CDD:290425
		zf-rbx1	<618..659	CDD:289448	9/22 (41%)
		zf-RING_2	619..659	CDD:290367	9/22 (41%)
SAN1	NP_010427.3	HRD1	<242..424	CDD:227568	34/186 (18%)
SAN1	NP_010427.3	zf-RING_2	<251..280	CDD:404518	9/22 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900