DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trc8 and RNFT2

DIOPT Version :9

Sequence 1:	NP_996303.1	Gene:	Trc8 / 43476	FlyBaseID:	FBgn0039668	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_001103373.1	Gene:	RNFT2 / 84900	HGNCID:	25905	Length:	444	Species:	Homo sapiens

Alignment Length:	323	Identity:	66/323 - (20%)
Similarity:	120/323 - (37%)	Gaps:	94/323 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   391 SLGTVSAVLFYILALQTGLTSLSPDKRFIRLCRNLCLLMTALLHFLHNIVSPILMSLSA----AR 451
            :|..:.||:.:   ||.||.       ||       |::.|.|.|.|.:...:.:.:::    |.
Human   152 ALSELKAVICW---LQKGLP-------FI-------LILLAKLCFQHKLGIAVCIGMASTFAYAN 199

  Fly   452 NPSR-------KRHVRA-LSVCAFLVVLSVSLLYHLWSQQSIST-----------------WLLA 491
            :..|       ||.|.. |.:.|||...::.:||...|||..::                 |::.
Human   200 STLREQVSLKEKRSVLVILWILAFLAGNTLYVLYTFSSQQLYNSLIFLKPNLEMLDFFDLLWIVG 264

  Fly   492 VTAFSVEVVV-----------KVLVSLATYTLF--LLDARRQFFWEKLDDYLYYVRAFGNSVEFC 543
            :..|.::.:.           |:::::.:...|  :::...|.|...:...|:|....|:.....
Human   265 IADFVLKYITIALKCLIVALPKIILAVKSKGKFYLVIEELSQLFRSLVPIQLWYKYIMGDDSSNS 329

  Fly   544 FGILLFINGAWILIFESAQN----ATGGGIRAI--MMCIHAYFNIWCEARAGWSVFMKRRSAVHK 602
            :    |:.|..|:::...::    ...||:|..  ::|....:.:
Human   330 Y----FLGGVLIVLYSLCKSFDICGRVGGVRKALKLLCTSQNYGV-------------------- 370

  Fly   603 ISALPEATPAQLQAFDDVCAICYQEMYSAKITRCRHFFHGVCLRKWLYVQDRCPLCHEIMMYT 665
                 .||..|.....|:||||..|.....|..|:|.|...||..||..:..||||..:.:.|
Human   371 -----RATGQQCTEAGDICAICQAEFREPLILLCQHVFCEECLCLWLDRERTCPLCRSVAVDT 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trc8	NP_996303.1	TRC8_N	122..590	CDD:290425	44/246 (18%)
		zf-rbx1	<618..659	CDD:289448	17/40 (43%)
		zf-RING_2	619..659	CDD:290367	17/39 (44%)
RNFT2	NP_001103373.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	13..41
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	92..149
		RING-HC_RNFT2	382..422	CDD:319656	17/39 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900