| Sequence 1: | NP_996303.1 | Gene: | Trc8 / 43476 | FlyBaseID: | FBgn0039668 | Length: | 809 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_757385.1 | Gene: | SYVN1 / 84447 | HGNCID: | 20738 | Length: | 617 | Species: | Homo sapiens |
| Alignment Length: | 490 | Identity: | 117/490 - (23%) |
|---|---|---|---|
| Similarity: | 180/490 - (36%) | Gaps: | 102/490 - (20%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 357 MTAVLGMTGVISMFCHYIGRGF-------------------QWYLLTYDDEEKSLGTVSAVLFY- 401
Fly 402 ---------------------ILALQTGLTSLSPDKRFIRLCRNLCLLMTALLHFLHNIVSPILM 445
Fly 446 SLSAARNPSRKRHVRALSVCAFLVVLS---VSLLYHLWSQQSISTWLLAVTAFSVEVVVKVLVSL 507
Fly 508 ATYTLFLLDARRQFFWEKLDDYLYYVRAFGNSVEFCFGILLFINGAWILIFESAQNATGGGIRAI 572
Fly 573 MMCIHAYFNIWCEARAGWSVFMKRRSAVHKISALPEATPAQLQAFDDVCAICYQEMYS-AKITRC 636
Fly 637 RHFFHGVCLRKWLYVQDRCPLCHEIMMYTDKADENAPEAEPA----PAAQAEQPMRIYPRDDANN 697
Fly 698 A------------AAQRRSPERAPVEASEQAPATSSSSAAA---TIGAEAVSAIVESAAAVGEAR 747
Fly 748 SLVSVASSSSATHRISASGSSDSSYMTASAQSPPP 782 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Trc8 | NP_996303.1 | TRC8_N | 122..590 | CDD:290425 | 53/276 (19%) |
| zf-rbx1 | <618..659 | CDD:289448 | 20/41 (49%) | ||
| zf-RING_2 | 619..659 | CDD:290367 | 19/40 (48%) | ||
| SYVN1 | NP_757385.1 | Involved in FAM8A1 interaction. /evidence=ECO:0000269|PubMed:28827405 | 1..251 | 52/261 (20%) | |
| Necessary and sufficient for SEL1L interaction. /evidence=ECO:0000269|PubMed:28827405 | 1..84 | 13/80 (16%) | |||
| HRD1 | 10..>333 | CDD:227568 | 83/347 (24%) | ||
| Interaction with p53/TP53. /evidence=ECO:0000269|PubMed:17170702 | 236..270 | 6/39 (15%) | |||
| zf-RING_2 | 289..330 | CDD:290367 | 19/40 (48%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 337..375 | 8/37 (22%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 393..453 | 21/72 (29%) | |||
| HAF-H domain, necessary to form higher-order Hrd1 complexes. /evidence=ECO:0000303|PubMed:28827405 | 480..535 | ||||
| Nha1_C | <528..611 | CDD:285783 | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 535..617 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_COG5243 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D897451at2759 | |
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 3 | 2.820 | |||||