DRSC/TRiP Functional Genomics Resources

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Protein Alignment Trc8 and Rnft1

DIOPT Version :9

Sequence 1:NP_996303.1 Gene:Trc8 / 43476 FlyBaseID:FBgn0039668 Length:809 Species:Drosophila melanogaster
Sequence 2:NP_084064.1 Gene:Rnft1 / 76892 MGIID:1924142 Length:395 Species:Mus musculus


Alignment Length:347 Identity:71/347 - (20%)
Similarity:121/347 - (34%) Gaps:116/347 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   364 TGVISMFCHYIGRGFQW------YLLTYDDEEKSLGTVSAVLFYILALQTGLTSLSPDKRFIRLC 422
            :|..|.| .|:   |:|      |:|.       || :..|:.:|..:..|:.            
Mouse    98 SGSFSEF-RYL---FKWLQKSLPYILI-------LG-IKLVMQHITGISLGIG------------ 138

  Fly   423 RNLCLLMTALLHFLHNIVSPILMSLSAARNPSRKRHVRALSVCAFLVVL---SVSLLYHLWSQQS 484
                 |:|..::...:||:.:.:     |..|.|..      ||:|:|.   |..|||:.:..||
Mouse   139 -----LLTTFMYANKSIVNQVFL-----RERSSKLR------CAWLLVFLAGSSVLLYYTFHSQS 187

  Fly   485 IS------------------TWLLAVTAFSVE---VVVKVLVSLAT----------YTLFLLDAR 518
            :.                  .|::.:|.|.::   :.:|.|:.|..          |...||:..
Mouse   188 LHYSLIFLNPTLEQLSFWEVLWIVGITDFILKFFFMGLKCLILLVPSFIMPFKSKGYWYMLLEEL 252

  Fly   519 RQFF--------WEKLDDYLYYVRAFGNSVEFCFGILLFINGAWILIFESAQNATGGGIRAIMMC 575
            .|::        |.:   ||.....|||...:..||||.:....:.:.:..     |.:|.....
Mouse   253 CQYYRIFVPIPVWFR---YLISYGEFGNVTTWSLGILLALLYLILKLLDFF-----GHLRTFRQV 309

  Fly   576 IHAYFNIWCEARAGWSVFMKRRSAVHKISALPEATPAQLQAFDDVCAICYQEMYSAKITRCRHFF 640
            :..:|     .|..:.|               .|:..|....|.:|.||..|.....:..|:|.|
Mouse   310 LRVFF-----TRPSYGV---------------PASKRQCSDMDGICTICQAEFQKPVLLFCQHIF 354

  Fly   641 HGVCLRKWLYVQDRCPLCHEIM 662
            ...|:..|...:..||||..::
Mouse   355 CEECITLWFNREKTCPLCRTVI 376

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Trc8NP_996303.1 TRC8_N 122..590 CDD:290425 54/273 (20%)
zf-rbx1 <618..659 CDD:289448 13/40 (33%)
zf-RING_2 619..659 CDD:290367 12/39 (31%)
Rnft1NP_084064.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..58
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 78..97
Required for ubiquitin ligase activity and for protection against ER stress-induced cell death. /evidence=ECO:0000250|UniProtKB:Q5M7Z0 328..379 14/49 (29%)
RING 335..376 CDD:238093 13/40 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5243
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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