Protein Alignment Trc8 and Rnf145

DIOPT Version :10

• Sequence 1: NP_996303.1
• Gene: Trc8 / 43476
• FlyBaseID: FBgn0039668
• Length: 809
• Species: Drosophila melanogaster
• Sequence 2: NP_083138.2
• Gene: Rnf145 / 74315
• MGIID: 1921565
• Length: 663
• Species: Mus musculus
• Alignment Length: 784
• Identity: 212/784 - (27%)
• Similarity: 346/784 - (44%)
• Gaps: 175/784 - (22%)

  Fly     1 MSVRTKVLGLVDVMMRVPPVMVIDEILKMDMGMQSWLYPDKDKASGALATPTEAPAVPSGQDPFT 65
            |:.:.|:..:::|.:|||.:|::|.:.:.|:
Mouse     1 MAAKEKLEAVLNVALRVPSIMLLDVLYRWDV---------------------------------- 31

  Fly    66 SIKELFSHMTTSAQSVLEQSIEKASEAAKTHGMLSSGFNSLMNELSKDQTLADVLSTTTVKFVLC 130
                          |...|.|:::|            .|:  |.|.:.:.||  |:...|.::|.
Mouse    32 --------------SSFFQQIQRSS------------LNN--NPLFQYKYLA--LNMHYVGYILS 66

  Fly   131 VFAFLSAACIFMLWTRHLVMVYMFLTSLGLTFLSYWSN----VSALALTERSPSMVEDLMSLN-- 189
            |       .:..|..:|||.:|::..:..|.:..:..:    .|.|......|..:|.| |:|
Mouse    67 V-------VLLTLPRQHLVQLYLYFVTALLLYAGHQISRDYVRSELESAYEGPMYLEPL-SMNRF 123

  Fly   190 TTRLLDSGGVVMSLAPHLMAQWFMGMLFAYIHLGPRFEHVQRSMPIIFASPILLAMLPLPAKVVQ 254
            ||.|:.. .||.:|...:|....:.:..|:                         ||||.|:
Mouse   124 TTALIGQ-LVVCTLCSCVMKTKQIWLFSAH-------------------------MLPLLAR--- 159

  Fly   255 HLPVVAVFTPIILTKITLMQSAMEASRTV-------YN----GYQYAMNFVSNFGLSALIENEWQ 308
             |.:|.:.|.:|:.|..::.:.:|....:       ||    .|:..:..|..:||.||..:.|.
Mouse   160 -LCLVPLETIVIINKFAMIFTGLEVLYFLGSNLLVPYNLAKSAYRELVQVVEVYGLLALGMSLWN 223

  Fly   309 RLNVPNVLRVFWTIRLIQGGYALATTESDEPLDLMTATQKLL-------VDGCETMTAVLGMT-- 364
            :|.||.:..|||.:......|:..:|. |:|    .:.::||       .:.|.|..::||:.
Mouse   224 QLVVPVLFMVFWLVLFALQIYSYFSTR-DQP----ASRERLLFLFLTSIAECCSTPYSLLGLVFT 283

  Fly   365 ------GVISMFCHYIGRGFQWYLLTYDDEEKSLGTVSAVLFYILALQTGLTSLSPDKRFIRLCR 423
                  ||::: |.:..:|::.::   :|...:.|....|...|||:||||..|....|...|..
Mouse   284 VSFVALGVLTL-CKFYLQGYRAFM---NDPAMNRGMTEGVTLLILAVQTGLIELQVVHRAFLLSI 344

  Fly   424 NLCLLMTALLHFLHNIVSPILMSLSAARNPSRKRHVRALSVCAFLVVLSVSLLYHLWSQQSISTW 488
            .|.:::.::|..:..|..||:::|.|:|:.|..:|.||:|:|.||:|....:.|.:.....:..|
Mouse   345 ILFIVVASILQSMLEIADPIVLALGASRDKSLWKHFRAVSLCLFLLVFPAYMAYMICQFFHMDFW 409

  Fly   489 LLAVTAFSVEVVVKVLVSLATYTLFLLDARRQFFWEKLDDYLYYVRAFGNSVEF-------CFGI 546
            ||.:.:.|:...::||.:|..|.||:::..|:...|.:||.:|||......:||       .:|:
Mouse   410 LLIIISSSILTSLQVLGTLFIYVLFMVEEFRKEPVENMDDVIYYVNGTYRLLEFVVALCVVAYGV 474

  Fly   547 LLFINGAWILIFESAQNATGGGIRAIMMCIHAYFNIWCEARAGWSVFMKRRSAVHKISALPEATP 611
            ...|.|.|.:            :.::::.||:|:|:|..|:.||..|:.||.||:||.:||.||.
Mouse   475 SETIFGEWTV------------MGSMIIFIHSYYNVWLRAQLGWKSFLLRRDAVNKIKSLPVATQ 527

  Fly   612 AQLQAFDDVCAICYQEMYSAKITRCRHFFHGVCLRKWLYVQDRCPLCHEIMMYTDKADENAPEAE 676
            .||:..:|:||||||:|.||.||.|.||||..||:|||||||.|||||..:..:.:......||.
Mouse   528 EQLEKHNDICAICYQDMKSAVITPCSHFFHAGCLKKWLYVQDTCPLCHCHLKNSSQLPGLGTEAA 592

  Fly   677 PAPAAQAEQPMRIYPRDDANNAAAQRRSPERAPVEASEQAPATSSSSAAATIGAEAVSAIVESAA 741
            |.|.|.|||           |...| ..|| .|...|.....|...|..::......||..|.||
Mouse   593 PQPPAGAEQ-----------NIVLQ-EGPE-PPDHESPPGTGTQEGSGDSSEHINRGSASQEGAA 644

  Fly   742 AVGE 745
            ..||
Mouse   645 DAGE 648

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trc8	NP_996303.1	TRC8_N	8..590	CDD:463960	141/620 (23%)
		RING-H2_RNF139-like	619..659	CDD:438139	29/39 (74%)
Rnf145	NP_083138.2	TRC8_N	8..506	CDD:463960	141/620 (23%)
		YLYF motif. /evidence=ECO:0000269|PubMed:29374057	81..84		1/2 (50%)
		HRD1	<520..627	CDD:227568	52/119 (44%)
		RING-H2_RNF145	533..575	CDD:319598	29/41 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	587..663		23/75 (31%)