DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trc8 and rnf145a

DIOPT Version :9

Sequence 1:	NP_996303.1	Gene:	Trc8 / 43476	FlyBaseID:	FBgn0039668	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	XP_005157379.1	Gene:	rnf145a / 565986	ZFINID:	ZDB-GENE-111012-3	Length:	649	Species:	Danio rerio

Alignment Length:	776	Identity:	202/776 - (26%)
Similarity:	341/776 - (43%)	Gaps:	181/776 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVRTKVLGLVDVMMRVPPVMVIDEILKMDMGMQSWLYPDKDKASGALATPTEAPAVPSGQDPFT 65
            |:|:.:|..:::|.:|||.:|:::.:.:.|:
Zfish     1 MAVKERVEAVLNVGLRVPSIMLLEVLYRWDV---------------------------------- 31

  Fly    66 SIKELFSHMTTSAQSVLEQSIEKASEAAKTHGMLSSGFNSLMNELSKDQTLADVLSTTTVKFVLC 130
                          |...|.|:::|            .|:  |.|.:.:.||         ..|.
Zfish    32 --------------SSFFQKIQRSS------------LNN--NPLFQYKYLA---------LYLH 59

  Fly   131 VFAFLSAACIFMLWTRHLVMVYMFLTSLGLTFLSYWSN----VSALALTERSPSMVEDLMSLN-- 189
            ...::.:..:..|..:|||.:|:::.:..|.|..:..:    .|.|......|..:|.| |:|
Zfish    60 YVGYILSLVLLTLPRQHLVQLYLYVLTALLLFAGHQISRDYVRSELESGYEGPLYLEPL-SINRF 123

  Fly   190 TTRLLDSGGVVMSLAPHLMAQ---WFMGMLFAYIHLGPRFEHVQRSMPIIFASPILLAMLPLP-- 249
            ||.|| ...||.:|...:|..   |    ||: .||          :|::    ..|.::||.
Zfish   124 TTALL-CQLVVCTLCSCVMQTKRIW----LFS-AHL----------LPLV----ARLCLVPLETI 168

  Fly   250 ------AKVVQHLPVVAVFTPIILTKITLMQSAMEASRTVYNGYQYAMNFVSNFGLSALIENEWQ 308
                  |.:...|.|:......:|....|.::|          |:.....|..:||.||..:.|.
Zfish   169 VFVNRFAMIFTGLEVIYFLASNLLVPFNLAKTA----------YRELAQVVEVYGLLALGMSLWN 223

  Fly   309 RLNVPNVLRVFWTIRLIQGGYALATTESDEPLDLMTATQKLL-------VDGCETMTAVLGMT-- 364
            :|.:|.:...||.:......|...:|. |:|    |:.::||       .:.|.|..::||:.
Zfish   224 QLVLPVLFMCFWLVLFALQIYTYFSTR-DQP----TSRERLLFLFLTSIAECCCTPYSLLGLVFT 283

  Fly   365 ------GVISMFCHYIGRGFQWYLLTYDDEEKSLGTVSAVLFYILALQTGLTSLSPDKRFIRLCR 423
                  ||::: |.:..:|::.::   :|.....|....:...|||:||||..|....|...|..
Zfish   284 VSFVALGVLTL-CKFYLQGYRAFM---NDNTMHRGMTEGITLLILAVQTGLIELQVIHRAFLLSI 344

  Fly   424 NLCLLMTALLHFLHNIVSPILMSLSAARNPSRKRHVRALSVCAFLVVLSVSLLYHLWSQQSISTW 488
            .|.:::.::|..:..|..||:::|.|:|:.|..:|.||:|:|.||:|....:.|.:.....:..|
Zfish   345 ILFIVVASILQSMLEIADPIVLALGASRDKSLWKHFRAVSLCLFLLVFPAYMSYMICQFFHMDFW 409

  Fly   489 LLAVTAFSVEVVVKVLVSLATYTLFLLDARRQFFWEKLDDYLYYVRAFGNSVEF-------CFGI 546
            ||.:.:.|:...::||.:|..|.||:::..|:...|.:||.:|:|......:||       .:|:
Zfish   410 LLIIISSSILTSLQVLGTLLIYVLFMVEELRKAPVENMDDVIYWVNGTYRLLEFLVALCVVAYGV 474

  Fly   547 LLFINGAWILIFESAQNATGGGIRAIMMCIHAYFNIWCEARAGWSVFMKRRSAVHKISALPEATP 611
            ...:.|.|.:            :.:.::.||:|:|:|..|:.||..|:.||.||:||.:||.|:.
Zfish   475 SETVFGEWTV------------MGSTIVLIHSYYNVWLRAQLGWQSFLLRRDAVNKIKSLPTASL 527

  Fly   612 AQLQAFDDVCAICYQEMYSAKITRCRHFFHGVCLRKWLYVQDRCPLCHEIMMYTDKADENA---- 672
            .|||..:|:|:||||:|.||.||.|.|.||..||:||||||:.|||||..:..:.:...::
Zfish   528 QQLQQHNDICSICYQDMTSAVITPCSHLFHAGCLKKWLYVQETCPLCHNQLKGSSQLGSSSQDVP 592

  Fly   673 PEAEPAPAAQAEQPMRIYPRDDANNAAAQRR--SPERAPVEASE---------QAPATSSS 722
            |:..||...:.:.|..  |.|..:|....|:  |..|||  |||         ..||.|||
Zfish   593 PQDTPAQPEEDQDPSE--PADSESNLQDLRQDDSSTRAP--ASELRARLKQQTDPPACSSS 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trc8	NP_996303.1	TRC8_N	122..590	CDD:290425	121/506 (24%)
		zf-rbx1	<618..659	CDD:289448	26/40 (65%)
		zf-RING_2	619..659	CDD:290367	26/39 (67%)
rnf145a	XP_005157379.1	TRC8_N	8..506	CDD:290425	136/620 (22%)
rnf145a	XP_005157379.1	zf-RING_2	535..575	CDD:290367	26/39 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9282
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D302551at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820