DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trc8 and CHFR

DIOPT Version :9

Sequence 1:	NP_996303.1	Gene:	Trc8 / 43476	FlyBaseID:	FBgn0039668	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_001154816.1	Gene:	CHFR / 55743	HGNCID:	20455	Length:	664	Species:	Homo sapiens

Alignment Length:	223	Identity:	49/223 - (21%)
Similarity:	75/223 - (33%)	Gaps:	46/223 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   611 PAQLQAFDDVCAICYQEMYSAKITRCRHFFHGVCLRKWLYVQDR-CPLCHEIMMYTDKADENAPE 674
            |:......|.|.|...|. |.::|.......|..:.|...|:.: |||....::|. ...:|.||
Human    51 PSNKLVSGDHCRIVVDEK-SGQVTLEDTSTSGTVINKLKVVKKQTCPLQTGDVIYL-VYRKNEPE 113

  Fly   675 AEPA--------------PAAQAEQPMRIYPRDDANNAAAQRRSPERAPVEA-------SEQAPA 718
            ...|              .:.:|.:....:...|.:.|.|.|.:..|.|..:       .|..|:
Human   114 HNVAYLYESLSEKQGMTQESFEANKENVFHGTKDTSGAGAGRGADPRVPPSSPATQVCFEEPQPS 178

  Fly   719 TSSSSAAATIGAEAVSAIVESAAAVGEARSLVSVASSSSATHRISASGSSDSSYMTASAQSPPPT 783
            ||:|....|..|.:.     ..:..|..||    :|..|....||..||           .|...
Human   179 TSTSDLFPTASASST-----EPSPAGRERS----SSCGSGGGGISPKGS-----------GPSVA 223

  Fly   784 ATSAAAVATAAASNTTHMFRM--SQDQQ 809
            :...::.|:|.....|..|..  .|||:
Human   224 SDEVSSFASALPDRKTASFSSLEPQDQE 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trc8	NP_996303.1	TRC8_N	122..590	CDD:290425
		zf-rbx1	<618..659	CDD:289448	12/41 (29%)
		zf-RING_2	619..659	CDD:290367	12/40 (30%)
CHFR	NP_001154816.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		FHA	16..105	CDD:238017	13/54 (24%)
		FHA	<31..140	CDD:224630	19/90 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	142..267		30/130 (23%)
		RING	303..346	CDD:238093
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	388..417
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	439..461
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900