DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trc8 and rnf139

DIOPT Version :9

Sequence 1:	NP_996303.1	Gene:	Trc8 / 43476	FlyBaseID:	FBgn0039668	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_001001242.1	Gene:	rnf139 / 407923	XenbaseID:	XB-GENE-488451	Length:	663	Species:	Xenopus tropicalis

Alignment Length:	781	Identity:	257/781 - (32%)
Similarity:	385/781 - (49%)	Gaps:	163/781 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VRTKVLGLVDVMMRVPPVMVIDEILKMDMGMQSWLYPDKDKASGALATPTEAPAVPSGQDPFTSI 67
            |..:|..::||.:|||.:.:.|.||.:                     |.:|
Frog     8 VGQRVRAVLDVALRVPSLFITDAILNL---------------------PHDA------------- 38

  Fly    68 KELFSHMTTSAQSVLEQSIEKASEAAKTHGMLSSGFNSLMNELSKDQTLADVLSTTTVKFVLCVF 132
                                            |:||.||:.:|:                 |.:.
Frog    39 --------------------------------SAGFLSLLLQLA-----------------LRLL 54

  Fly   133 AFLSAACIFMLWTRHLVMVYMFLTSLGL----TFLSYWSNVSALALTERSPSMVEDLMSLNTTRL 193
            ..:::..:.:|..|.|...||...:|.|    ..:||::.                 :.||.:|.
Frog    55 GVVASIVVLVLSRRALFKFYMITAALALAATSVLVSYYAT-----------------LHLNFSRA 102

  Fly   194 LDSGGVVMSLAPHLMAQWFMGMLFAYIHLGPRF---EHVQRSMPIIFAS---PILLAMLPLPAKV 252
            ..|..:.:...|......:|.::...:..|..|   ..||....:|...   |.:..::.||..|
Frog   103 SYSAALGLEFLPSNGPSLWMTLIVLQLIFGIGFITLLQVQSYSQLIILDLLIPTVGFIIELPLGV 167

  Fly   253 VQHLPVVAVFTPIILTKITLMQSAMEASRTVYNGYQYAMNFVSN----FGLSALIENEWQRLNVP 313
            .|.|..::....|:.|...|    ....|..|...:|.:..:.:    :|:..::|:.|::::.|
Frog   168 QQILVFISALVLILYTVACL----AFRFRWFYYSTKYTVLLLKHMYQVYGIQLMVEDAWKKIHFP 228

  Fly   314 NVLRVFWTIRLIQGG----YALATTESDE-------PL-DLMTATQKLLVDGCETMTAVLGMTGV 366
            :||||||..||....    |.:..:.||.       |. ||......|:::||::...||||:.|
Frog   229 DVLRVFWLTRLATQAVFLFYVVRESSSDAGEVSYFIPWNDLSELVCNLIINGCDSTLTVLGMSAV 293

  Fly   367 ISMFCHYIGRGFQWYLLTYDDEEKSLGTVSAVLFYILALQTGLTSLSPDKRFIRLCRNLCLLMTA 431
            ||...||:|.|...::.:.::|:|.||.|:.|||:||||||||:.|.|::|.:|||||:|||:||
Frog   294 ISSIAHYLGLGILAFIGSTEEEDKRLGFVAPVLFFILALQTGLSGLKPEERLVRLCRNMCLLLTA 358

  Fly   432 LLHFLHNIVSPILMSLSAARNPSRKRHVRALSVCAFLVVLSVSLLYHLWSQQSISTWLLAVTAFS 496
            :|||:|.:..|:||||||:...|.:||:..|.|...|.||.|.|...||...:::|||.|||||.
Frog   359 VLHFIHGMTDPVLMSLSASHVSSYRRHLPVLLVSVCLFVLPVLLSCVLWHYYALNTWLFAVTAFC 423

  Fly   497 VEVVVKVLVSLATYTLFLLDARRQFFWEKLDDYLYYVRAFGNSVEFCFGILLFINGAWILIFESA 561
            ||:.:||:|||..||||::|......|||||||:||||:.|:.:||.||:::|.|||:.::|||
Frog   424 VELCLKVIVSLTVYTLFMIDGYYSVLWEKLDDYVYYVRSTGSIIEFIFGVIMFGNGAYTMMFES- 487

  Fly   562 QNATGGGIRAIMMCIHAYFNIWCEARAGWSVFMKRRSAVHKISALPEATPAQLQAFDDVCAICYQ 626
                |..|||.|||:||||||:.:|:.||..||.||.||.||::|||...::.:..|||||||||
Frog   488 ----GSKIRACMMCLHAYFNIYLQAKNGWKTFMNRRKAVKKINSLPEVKGSESREIDDVCAICYQ 548

  Fly   627 EMY-SAKITRCRHFFHGVCLRKWLYVQDRCPLCHEIMMYTDKADEN----------APEAEPA-P 679
            |.: ||:||.|.|:||.:|||||||:||.||:||:.:...|.:.||          ||..||| |
Frog   549 EFHTSARITPCHHYFHALCLRKWLYIQDTCPMCHQKVYIDDDSKENASVSNNNGFVAPNEEPAQP 613

  Fly   680 AAQAEQPMRIYPRDDANNAAAQRRSPERAPVEASEQAPATSSSSAAATIGAEAVSAIVESAAAVG 744
            .|..|          |:....::...|...||..::...|...::.:   .|.||   :...::|
Frog   614 DADRE----------ADQELEEQNLSEDDSVECDDEEWTTEPHNSTS---EEHVS---DDTDSLG 662

  Fly   745 E 745
            |
Frog   663 E 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trc8	NP_996303.1	TRC8_N	122..590	CDD:290425	174/493 (35%)
		zf-rbx1	<618..659	CDD:289448	29/41 (71%)
		zf-RING_2	619..659	CDD:290367	28/40 (70%)
rnf139	NP_001001242.1	TRC8_N	13..512	CDD:372682	190/607 (31%)
		RAD18	527..>661	CDD:227719	53/149 (36%)
		RING-H2_RNF139	541..582	CDD:319597	28/40 (70%)
		RING-H2 finger (C3H2C3-type)	543..581	CDD:319597	26/37 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	288	1.000	Domainoid score	I1547
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5222
Inparanoid	1	1.050	390	1.000	Inparanoid score	I1952
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D302551at33208
OrthoFinder	1	1.000	-	-		FOG0008390
OrthoInspector	1	1.000	-	-		oto105227
Panther	1	1.100	-	-	LDO	PTHR22763
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6571
SonicParanoid	1	1.000	-	-		X6380
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.100