DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trc8 and Syvn1

DIOPT Version :9

Sequence 1:	NP_996303.1	Gene:	Trc8 / 43476	FlyBaseID:	FBgn0039668	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	XP_006230914.1	Gene:	Syvn1 / 361712	RGDID:	1310488	Length:	612	Species:	Rattus norvegicus

Alignment Length:	492	Identity:	114/492 - (23%)
Similarity:	179/492 - (36%)	Gaps:	115/492 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   357 MTAVLGMTGVISMFCHYIGRGF-------------------QWYLLTYDDEEKSLGTVSAVLFY- 401
            |.|.|.:||.:....:|:...|                   |.::|.:     .||.|...:|:
  Rat     8 MAASLALTGAVVAHAYYLKHQFYPTVVYLTKSSPSMAVLYIQAFVLVF-----LLGKVMGKVFFG 67

  Fly   402 ---------------------ILALQTGLTSLSPDKRFIRLCRNLCLLMTALLHFLHNIVSPILM 445
                                 .||........||  ||:.|   ..||:  .|...|.:....:.
  Rat    68 QLRAAEMEHLLERSWYAVTETCLAFTVFRDDFSP--RFVAL---FTLLL--FLKCFHWLAEDRVD 125

  Fly   446 SLSAARNPSRKRHVRALSVCAFLVVLS---VSLLYHLWSQQSISTWLLAVTAFSVEVVVKVLVSL 507
            .:..:.|.|...|.|.:|:...|.:|.   ||..||....:..|..|:....::: ::..||...
  Rat   126 FMERSPNISWLFHCRIVSLMFLLGILDFLFVSHAYHSILTRGASVQLVFGFEYAI-LMTMVLTIF 189

  Fly   508 ATYTLFLLDARRQFFWEKLDDYLYYVRAFGNSVEFCFGILLFINGAWILIFESAQNATGGGIRAI 572
            ..|.|..:|.:.:..|:....|:.|...|...::    :||::  |::.|...........||.:
  Rat   190 IKYVLHSVDLQSENPWDNKAVYMLYTELFTGFIK----VLLYM--AFMTIMIKVHTFPLFAIRPM 248

  Fly   573 MMCIHAYFNIWCEARAGWSVFMKRRSAVHKISALPEATPAQLQAFDDVCAICYQEMYS-AKITRC 636
            .:.:..:      .:|.....|.||:..:..:..|:|||.:|||.|:||.||.:||.: ||...|
  Rat   249 YLAMRQF------KKAVTDAIMSRRAIRNMNTLYPDATPEELQAMDNVCIICREEMVTGAKRLPC 307

  Fly   637 RHFFHGVCLRKWLYVQDRCPLCHEIMMYTDKADENAPEAEP----APAAQAEQPMRIYPRDDANN 697
            .|.||..|||.|...|..||.|...::......::.|..||    ||.|....|:...|.:....
  Rat   308 NHIFHTSCLRSWFQRQQTCPTCRMDVLRASLPAQSPPPPEPADQGAPPAPHPPPLLPQPPNFPQG 372

  Fly   698 A------------AAQRRSPERAPVEASEQAPATSSSSAAATIGAEAVSAIVESAAAVGEARSLV 750
            .            ......|...|..:|.:|.|..|:|||.:
  Rat   373 LLPPFPPGMFPLWPPMGPFPPVPPPPSSGEAAAPPSTSAATS----------------------- 414

  Fly   751 SVASSSSATHRISASGSSDSSYMTASAQSPPPTATSA 787
              ..|.:||  .:|:|:|.|:  .||...|.|.|..|
  Rat   415 --RPSGAAT--TTAAGTSTSA--PASGSVPGPEAGPA 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trc8	NP_996303.1	TRC8_N	122..590	CDD:290425	53/276 (19%)
		zf-rbx1	<618..659	CDD:289448	20/41 (49%)
		zf-RING_2	619..659	CDD:290367	19/40 (48%)
Syvn1	XP_006230914.1	HRD1	10..>333	CDD:227568	83/347 (24%)
Syvn1	XP_006230914.1	fibronec_FbpA	<524..>597	CDD:411474
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D897451at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820