DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trc8 and Amfr

DIOPT Version :9

Sequence 1:	NP_996303.1	Gene:	Trc8 / 43476	FlyBaseID:	FBgn0039668	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	XP_038954087.1	Gene:	Amfr / 361367	RGDID:	1311551	Length:	643	Species:	Rattus norvegicus

Alignment Length:	333	Identity:	81/333 - (24%)
Similarity:	118/333 - (35%)	Gaps:	85/333 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   399 LFYILALQTGLTSLSPDKRFIRLCRNLCLLMTALLHFLHNIV---SPILMSLSAARNPSRKRHVR 460
            :||......|:.::...:..:..|     |..|.|.|||.:|   ......||.:.......|.|
  Rat   126 IFYKFIFIFGVLNVQTVEEVVMWC-----LWFAGLVFLHLMVQLCKDRFEYLSFSPTTPMSSHGR 185

  Fly   461 ALSV--------CAFLVVLSVSLLYHLWSQQSISTWLLAVTAFSVEVVVKVLVSLATYTLFLLDA 517
            .||:        |...||..|:...|     .:.| |..:.|.|:.|.|:....:..|.:.|.|.
  Rat   186 VLSLLIAMLLSCCGLAVVCCVTGYTH-----GMHT-LAFMAAESLLVTVRTAHVILRYVIHLWDL 244

  Fly   518 RRQFFWEKLDDYLYYVRAFGNSVEFCFGILLFINGAWILIFESAQNATGGGIRAIMMCIH--AYF 580
            ..:..||....|:||       .:|...::|       |..:            :|..||  .:.
  Rat   245 NHEGTWEGKGTYVYY-------TDFVMELML-------LSLD------------LMHHIHMLLFG 283

  Fly   581 NIWCEARAGWSVFMKRRSAVHKI------------------SALPEATPAQLQAFDDVCAICYQE 627
            |||. :.|...:||:.|...|::                  :....||..:|...:|.||||:..
  Rat   284 NIWL-SMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARFAVATAEELAVNNDDCAICWDS 347

  Fly   628 MYSAKITRCRHFFHGVCLRKWLYVQDRCPLCHEIMMYTD-----------KADENAPEAEPAPAA 681
            |.:|:...|.|.||..|||.||.....||.|...:...|           ..|||.     .|.|
  Rat   348 MQAARKLPCGHLFHNSCLRSWLEQDTSCPTCRMSLNIADGSRAREDHQGENLDENL-----VPVA 407

  Fly   682 QAEQPMRI 689
            .||...|:
  Rat   408 AAEGRPRL 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trc8	NP_996303.1	TRC8_N	122..590	CDD:290425	46/203 (23%)
		zf-rbx1	<618..659	CDD:289448	18/40 (45%)
		zf-RING_2	619..659	CDD:290367	18/39 (46%)
Amfr	XP_038954087.1	HRD1	86..>382	CDD:227568	72/293 (25%)
		RING-H2_AMFR	339..382	CDD:319369	19/42 (45%)
		CUE_AMFR	458..498	CDD:270604
		G2BR	575..600	CDD:375868
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D897451at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920