DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trc8 and syvn1

DIOPT Version :9

Sequence 1:	NP_996303.1	Gene:	Trc8 / 43476	FlyBaseID:	FBgn0039668	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_997900.2	Gene:	syvn1 / 335226	ZFINID:	ZDB-GENE-030131-7166	Length:	618	Species:	Danio rerio

Alignment Length:	458	Identity:	117/458 - (25%)
Similarity:	171/458 - (37%)	Gaps:	92/458 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   372 HYIGRGFQWYLLTYDDEEKSLGTVSAVLFYILALQTGLTSLSPDKRFIRLCRNLCLLMTALLHFL 436
            |.|.|  .||               ||....||........||  ||:.|   ..||:  .|...
Zfish    76 HLIER--SWY---------------AVTETCLAFTVFRDDFSP--RFVAL---FTLLL--FLKCF 116

  Fly   437 HNIVSPILMSLSAARNPSRKRHVRALSVCAFLVVLSVSLLYHLWSQQSISTWLLAV-TAFSVE-- 498
            |.:....:..:..:.|.|...|.|.||:...|.|:....:.|  :..||.|...:| ..|..|
Zfish   117 HWLAEDRVDFMERSPNISWVFHFRVLSLMVLLGVMDFLFVNH--ACHSIITRGASVQLVFGFEYA 179

  Fly   499 -VVVKVLVSLATYTLFLLDARRQFFWEKLDDYLYYVRAFGNSVEFCFGILLFINGAWILIFESAQ 562
             ::..||.:...|||..:|.:.:..|:....|:.|...|...::    :||::  |::.|.....
Zfish   180 ILMTMVLTTFIKYTLHTIDLQSENPWDNKAVYMLYTELFTGFIK----VLLYM--AFMTIMIKVH 238

  Fly   563 NATGGGIRAIMMCIHAYFNIWCEARAGWSVFMKRRSAVHKISALPEATPAQLQAFDDVCAICYQE 627
            ......||.:.:.:..:      .:|.....|.||:..:..:..|:|||..|||.|:||.||.:|
Zfish   239 TFPLFAIRPMYLAMRQF------KKAVTDAIMSRRAIRNMNTLYPDATPEDLQATDNVCIICREE 297

  Fly   628 MYS-AKITRCRHFFHGVCLRKWLYVQDRCPLCH-EIMMYTDKADENAPEAEPAPAAQAEQPMRIY 690
            |.: ||...|.|.||..|||.|...|..||.|. :::..:......||.|..|||..|.....|.
Zfish   298 MVTGAKKLPCNHIFHSSCLRSWFQRQQTCPTCRMDVLRASQPNQTPAPPAAQAPAPPAPANAPIP 362

  Fly   691 PRDDANNAAAQRRSP---------ERAPVEASEQAPA----TSSSSAAATIGAEAVSAIVESAAA 742
            |..:.......:..|         ..||..|...|||    |...|:....|||        :.|
Zfish   363 PPVNVAPGMMPQFPPGLFPFWGPFPGAPPPAVPGAPAAPTDTPQPSSEGAQGAE--------SGA 419

  Fly   743 VGEARSLVSVASSSSATHRISASGSSDSSYMT-------------------ASAQSPPPTATSAA 788
            .|.|:|....||        :|.|:......|                   .|:..|||::.|:.
Zfish   420 GGLAQSTADAAS--------AAPGAMPGFPFTMPPPFPSAPWLPMPPPPPFMSSMPPPPSSLSSM 476

  Fly   789 AVA 791
            :.|
Zfish   477 SEA 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trc8	NP_996303.1	TRC8_N	122..590	CDD:290425	50/221 (23%)
		zf-rbx1	<618..659	CDD:289448	20/41 (49%)
		zf-RING_2	619..659	CDD:290367	19/40 (48%)
syvn1	NP_997900.2	PMT_2	21..>256	CDD:304453	49/217 (23%)
		Interaction with p53/TP53. /evidence=ECO:0000250	236..270		6/39 (15%)
		zf-RING_2	289..330	CDD:290367	19/40 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	337..361		7/23 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	390..434		16/59 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	462..487		6/18 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D897451at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6571
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.950