DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trc8 and Rnf139

DIOPT Version :9

Sequence 1:	NP_996303.1	Gene:	Trc8 / 43476	FlyBaseID:	FBgn0039668	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_001121017.1	Gene:	Rnf139 / 315000	RGDID:	1306670	Length:	656	Species:	Rattus norvegicus

Alignment Length:	768	Identity:	259/768 - (33%)
Similarity:	379/768 - (49%)	Gaps:	161/768 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KVLGLVDVMMRVPPVMVIDEILKMDMGMQSWLYPDKDKASGALATPTEAPAVPSGQDPFTSIKEL 70
            :|...::|.:|||.:.:||.|...        |.|                  |.|..|....::
  Rat     5 QVWAALEVALRVPCLYIIDAIFNS--------YYD------------------SSQSRFCIGLQI 43

  Fly    71 FSHMTTSAQSVLEQSIEKASEAAKTHGMLSSGFNSLMNELSKDQTLADVLSTTTVKFVLCVFAFL 135
            |..:.                     |::.|....::::.|            ..||.:...|||
  Rat    44 FLRLL---------------------GIVVSSIVLILSQRS------------LFKFYMYSSAFL 75

  Fly   136 SAACIFMLWTRHLVMVYMFLTSLGLTFLSYWSNVSALA---LTERSPSMVEDLMSLNTTRLLDSG 197
            .||      |..||..|   .:|.:.|...: |.||..   |..:.||:   .|:|...:|....
  Rat    76 LAA------TSVLVNYY---AALHIDFYGAY-NTSAFGIELLPRKGPSL---WMALIVLQLTFGI 127

  Fly   198 GVVMSLAPHLMAQWFMGMLFAYIHLGPRFEHVQRSMPIIFASPILLAMLPLPAKVVQHLPVVAVF 262
            |.|..|                        |:|.    |::..|:|.:|.....::..||:....
  Rat   128 GYVTLL------------------------HIQS----IYSQLIILNILVPVIGLITELPLHIRE 164

  Fly   263 TPIILTKITLMQSAMEASRTVYNGYQYAMNFV--------SNFGLSALIENEWQRLNVPNVLRVF 319
            |.:.::.:.|:.:.|.........:.|:..:|        ..:||..|:|:.|:|:..|::||||
  Rat   165 TLVFMSSLILIFNTMLVLAVKLKWFYYSTRYVYLLVRHMYRIYGLQLLMEDTWKRIRFPDILRVF 229

  Fly   320 WTIRLIQGGYALAT-----------TES-----DEPLDLMTATQKLLVDGCETMTAVLGMTGVIS 368
            |..|:.    |.||           |||     |:..|::.   .|::.||::...||||:.|||
  Rat   230 WLTRIT----AQATVLMYILRMANETESFLISWDDFWDIIC---NLIISGCDSTLTVLGMSAVIS 287

  Fly   369 MFCHYIGRGFQWYLLTYDDEEKSLGTVSAVLFYILALQTGLTSLSPDKRFIRLCRNLCLLMTALL 433
            ...||:|.|...::.:.:::::.||.|:.|||:||||||||:.|.|::|.|||.||:|||:||:|
  Rat   288 SIAHYLGLGILAFIGSTEEDDRRLGFVAPVLFFILALQTGLSGLRPEERLIRLSRNMCLLLTAVL 352

  Fly   434 HFLHNIVSPILMSLSAARNPSRKRHVRALSVCAFLVVLSVSLLYHLWSQQSISTWLLAVTAFSVE 498
            ||:|.:..|:||||||:...|..||...|.|.|.|.:|.|.|.|.||...:::|||.|||||.||
  Rat   353 HFIHGMTDPVLMSLSASHVSSFHRHFPVLFVSACLFILPVLLSYVLWHHYALNTWLFAVTAFCVE 417

  Fly   499 VVVKVLVSLATYTLFLLDARRQFFWEKLDDYLYYVRAFGNSVEFCFGILLFINGAWILIFESAQN 563
            :.:||:|||..||||::|......|||||||:|:||:.||.:||.||:::|.|||:.::|||
  Rat   418 LCLKVIVSLTVYTLFMIDGYYNVLWEKLDDYVYFVRSTGNIIEFIFGVVMFGNGAYTMMFES--- 479

  Fly   564 ATGGGIRAIMMCIHAYFNIWCEARAGWSVFMKRRSAVHKISALPEATPAQLQAFDDVCAICYQEM 628
              |..|||.|||:||||||:.:.:.||..||.||:||.||::|||...:.||..||||||||.|.
  Rat   480 --GSKIRACMMCLHAYFNIYLQVKNGWKTFMNRRTAVKKINSLPEIKGSHLQEIDDVCAICYHEF 542

  Fly   629 -YSAKITRCRHFFHGVCLRKWLYVQDRCPLCHEIMMYTDKADEN----------APEAEPAPAAQ 682
             .||:||.|.|:||.:|||||||:||.||:||:.:...|...:|          ||.....|
  Rat   543 TTSARITPCNHYFHALCLRKWLYIQDTCPMCHQKVYIEDDIKDNSNVSNNNGFIAPNENQNP--- 604

  Fly   683 AEQPMRIYPRDDANNAAAQRRSPERAPVEASEQAPATSSSSAAATIGAEAVSA 735
             |:.:    |:||  |.:.|...|....:..:......:.....| ||.|.:|
  Rat   605 -EEAL----REDA--AGSDREMNEDDSTDCDDDIQRERNGGIQHT-GAAAAAA 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trc8	NP_996303.1	TRC8_N	122..590	CDD:290425	180/494 (36%)
		zf-rbx1	<618..659	CDD:289448	28/41 (68%)
		zf-RING_2	619..659	CDD:290367	27/40 (68%)
Rnf139	NP_001121017.1	TRC8_N	7..504	CDD:290425	196/608 (32%)
		zf-rbx1	<532..574	CDD:289448	28/41 (68%)
		RING	535..577	CDD:238093	27/41 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346082
Domainoid	1	1.000	285	1.000	Domainoid score	I1542
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5222
Inparanoid	1	1.050	383	1.000	Inparanoid score	I1973
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D302551at33208
OrthoFinder	1	1.000	-	-		FOG0008390
OrthoInspector	1	1.000	-	-		oto98535
orthoMCL	1	0.900	-	-		OOG6_108947
Panther	1	1.100	-	-	LDO	PTHR22763
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6380
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.800