DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trc8 and Rnf145

DIOPT Version :9

Sequence 1:	NP_996303.1	Gene:	Trc8 / 43476	FlyBaseID:	FBgn0039668	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_001099248.1	Gene:	Rnf145 / 287212	RGDID:	1309561	Length:	664	Species:	Rattus norvegicus

Alignment Length:	793	Identity:	210/793 - (26%)
Similarity:	351/793 - (44%)	Gaps:	195/793 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVRTKVLGLVDVMMRVPPVMVIDEILKMDMGMQSWLYPDKDKASGALATPTEAPAVPSGQDPFT 65
            |:.:.|:..:::|.:|||.:|::|.:.:.|:
  Rat     1 MAAKEKLEAVLNVALRVPSIMLLDVLYRWDV---------------------------------- 31

  Fly    66 SIKELFSHMTTSAQSVLEQSIEKASEAAKTHGMLSSGFNSLMNELSKDQTLADVLSTTTVKFVLC 130
                          |...|.|:::|        ||:      |.|.:.:.||  |:...|.::|.
  Rat    32 --------------SSFFQQIQRSS--------LSN------NPLFQYKYLA--LNMHYVGYILS 66

  Fly   131 VFAFLSAACIFMLWTRHLVMVYM-FLTSLGLTFLSYWSNV-------SALALTERSPSMVEDLMS 187
            |       .:..|..:|||.:|: |||:|    |.|..:.       |.|......|..:|.| |
  Rat    67 V-------VLLTLPRQHLVQLYLYFLTAL----LLYAGHQISRDYVRSELESAYEGPMYLEPL-S 119

  Fly   188 LN--TTRLLDSGGVVMSLAPHLMAQWFMGMLFAYIHLGPRFEHVQRSMPIIFASPILLAMLPLPA 250
            :|  ||.|:.. .||.:|...:|....:.:..|:                         ||||.|
  Rat   120 MNRFTTALIGQ-LVVCTLCSCVMKTKQIWLFSAH-------------------------MLPLLA 158

  Fly   251 KVVQHLPVVAVFTPIILTKITLMQSAMEASRTV-------YN----GYQYAMNFVSNFGLSALIE 304
            :    |.:|.:.|.:|:.|..::.:.:|....:       ||    .|:..:..|..:||.||..
  Rat   159 R----LCLVPLETIVIINKFAMIFTGLEVLYFLGSNLLVPYNLAKSAYRELVQVVEVYGLLALGM 219

  Fly   305 NEWQRLNVPNVLRVFWTIRLIQGGYALATTESDEPLDLMTATQKLL-------VDGCETMTAVLG 362
            :.|.:|.||.:..|||.:......|:..:|. |:|    .:.::||       .:.|.|..::||
  Rat   220 SLWNQLVVPVLFMVFWLVLFALQIYSYFSTR-DQP----ASRERLLFLFLTSIAECCSTPYSLLG 279

  Fly   363 MT--------GVISMFCHYIGRGFQWYLLTYDDEEKSLGTVSAVLFYILALQTGLTSLSPDKRFI 419
            :.        ||::: |.:..:|::.::   :|...:.|....|...|||:||||..|....|..
  Rat   280 LVFTVSFVALGVLTL-CKFYLQGYRAFM---NDPAMNRGMTEGVTLLILAVQTGLIELQVVHRAF 340

  Fly   420 RLCRNLCLLMTALLHFLHNIVSPILMSLSAARNPSRKRHVRALSVCAFLVVLSVSLLYHLWSQQS 484
            .|...|.:::.::|..:..|..||:::|.|:|:.|..:|.||:|:|.||:|....:.|.:.....
  Rat   341 LLSIILFIVVASILQSMLEIADPIVLALGASRDKSLWKHFRAVSLCLFLLVFPAYMAYMICQFFH 405

  Fly   485 ISTWLLAVTAFSVEVVVKVLVSLATYTLFLLDARRQFFWEKLDDYLYYVRAFGNSVEF------- 542
            :..|||.:.:.|:...::||.:|..|.||:::..|:...|.:||.:|||......:||
  Rat   406 MDFWLLIIISSSILTSLQVLGTLFIYVLFMVEEFRKEPVENMDDVIYYVNGTYRLLEFLVALCVV 470

  Fly   543 CFGILLFINGAWILIFESAQNATGGGIRAIMMCIHAYFNIWCEARAGWSVFMKRRSAVHKISALP 607
            .:|:...|.|.|.:            :.::::.||:|:|:|..|:.||..|:.||.||:||.:||
  Rat   471 AYGVSETIFGEWTV------------MGSMIIFIHSYYNVWLRAQLGWKSFLLRRDAVNKIKSLP 523

  Fly   608 EATPAQLQAFDDVCAICYQEMYSAKITRCRHFFHGVCLRKWLYVQDRCPLCHEIMMYTDK----A 668
            .||..||:..:|:||||||:|.||.||.|.||||..||:|||||||.|||||..:..:.:    .
  Rat   524 IATKEQLERHNDICAICYQDMKSAVITPCSHFFHAGCLKKWLYVQDTCPLCHCHLKNSSQLPGLG 588

  Fly   669 DENAPEAEPAPAAQAEQPMRIYPRDDANNAAAQRRSPERAPVEASEQAPATSSSSAAATIGAEAV 733
            .|.||:   .|.|.|||.:.:                :..|.....:.|....:...:...:|.:
  Rat   589 TEPAPQ---PPVAGAEQNIVL----------------QEGPEPPDHETPPGPGAQEGSGDNSEYI 634

  Fly   734 SAIVESAAAVGEA 746
            :.  .||:..|:|
  Rat   635 NR--SSASREGDA 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trc8	NP_996303.1	TRC8_N	122..590	CDD:290425	129/510 (25%)
		zf-rbx1	<618..659	CDD:289448	29/40 (73%)
		zf-RING_2	619..659	CDD:290367	29/39 (74%)
Rnf145	NP_001099248.1	TRC8_N	8..506	CDD:404574	147/624 (24%)
		HRD1	<520..643	CDD:227568	50/143 (35%)
		RING-H2_RNF145	533..575	CDD:319598	29/41 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	73	1.000	Domainoid score	I9055
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D302551at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.780