DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trc8 and Amfr

DIOPT Version :9

Sequence 1:	NP_996303.1	Gene:	Trc8 / 43476	FlyBaseID:	FBgn0039668	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_035917.2	Gene:	Amfr / 23802	MGIID:	1345634	Length:	639	Species:	Mus musculus

Alignment Length:	334	Identity:	82/334 - (24%)
Similarity:	119/334 - (35%)	Gaps:	87/334 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   399 LFYILALQTGLTSLSPDKRFIRLCRNLCLLMTALLHFLHNIV---SPILMSLSAARNPSRKRHVR 460
            :||......|:.::...:..:..|     |..|.|.|||.:|   ......||.:.......|.|
Mouse   122 IFYKFIFIFGVLNVQTVEEVVMWC-----LWFAGLVFLHLMVQLCKDRFEYLSFSPTTPMSSHGR 181

  Fly   461 ALSV--------CAFLVVLSVSLLYHLWSQQSISTWLLAVTAFSVEVVVKVLVSLATYTLFLLDA 517
            .||:        |...||..|:...|     .:.| |..:.|.|:.|.|:....:..|.:.|.|.
Mouse   182 VLSLLIAMLLSCCGLAVVCCVTGYTH-----GMHT-LAFMAAESLLVTVRTAHVILRYVIHLWDL 240

  Fly   518 RRQFFWEKLDDYLYYVRAFGNSVEFCFGI-LLFINGAWILIFESAQNATGGGIRAIMMCIH--AY 579
            ..:..||....|:||       .:|...: ||.::                    :|..||  .:
Mouse   241 NHEGTWEGKGTYVYY-------TDFVMELALLSLD--------------------LMHHIHMLLF 278

  Fly   580 FNIWCEARAGWSVFMKRRSAVHKI------------------SALPEATPAQLQAFDDVCAICYQ 626
            .|||. :.|...:||:.|...|::                  :....|||.:|...:|.||||:.
Mouse   279 GNIWL-SMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWD 342

  Fly   627 EMYSAKITRCRHFFHGVCLRKWLYVQDRCPLCHEIMMYTD-----------KADENAPEAEPAPA 680
            .|.:|:...|.|.||..|||.||.....||.|...:...|           ..|||.     .|.
Mouse   343 SMQAARKLPCGHLFHNSCLRSWLEQDTSCPTCRMSLNIADGSRAREDHQGENLDENL-----VPV 402

  Fly   681 AQAEQPMRI 689
            |.||...|:
Mouse   403 AAAEGRPRL 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trc8	NP_996303.1	TRC8_N	122..590	CDD:290425	46/204 (23%)
		zf-rbx1	<618..659	CDD:289448	18/40 (45%)
		zf-RING_2	619..659	CDD:290367	18/39 (46%)
Amfr	NP_035917.2	HRD1	82..>378	CDD:227568	73/294 (25%)
		zf-RING_2	335..375	CDD:290367	18/39 (46%)
		CUE_AMFR	454..494	CDD:270604
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..531
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	594..620
		VCP/p97-interacting motif (VIM). /evidence=ECO:0000250\|UniProtKB:Q9UKV5	618..636
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810