DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trc8 and rnf-145

DIOPT Version :9

Sequence 1:	NP_996303.1	Gene:	Trc8 / 43476	FlyBaseID:	FBgn0039668	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_491382.2	Gene:	rnf-145 / 172053	WormBaseID:	WBGene00022471	Length:	742	Species:	Caenorhabditis elegans

Alignment Length:	704	Identity:	163/704 - (23%)
Similarity:	286/704 - (40%)	Gaps:	111/704 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 SIKELFSHMTTSAQSVLEQSIEKASEAAKTHGML---------SSGFNSLMNELSKDQTLADVLS 121
            |::...:.|.|..:.:.|.||.......:..|:|         ...|..:.:::.|...|:....
Worm    29 SVRLGVAQMDTGFKKIKEMSIMVLETGLRLPGLLFIELLWRYQGFSFEDISDDMMKQTPLSYFDI 93

  Fly   122 TTTVKFV------------LCVFAFLSAACIFMLWTRHLVMVYMFLTSLGLTFLSYWSNVSALAL 174
            .|.:.||            |..|....:.....|....|:.:|....|:.|..::|  .:||:.:
Worm    94 PTMLDFVHRRNFDHHAAIILSYFVIFISLMFLTLPLSRLIRMYSHFLSVFLFGVAY--KLSAIYV 156

  Fly   175 TERSPSMVEDLMSLNTTRLLDSGGVVMSLAPHLMAQWFMGMLFAYIHLGPRFEHVQRSMPIIFAS 239
            .....:..|:| .|:....|:..|.      |.:||..:.:|.:.: |....|..:.::| :||.
Worm   157 DLEMKTGEEEL-KLDGLIKLERHGF------HFLAQMLLVVLQSML-LEVDGEPWRVALP-VFAL 212

  Fly   240 PILLAMLPLPAKVVQHL-------PVVAVFTPIILTKITLMQSAMEASRTVYNGYQYAMNFVSNF 297
            ||:..|...|...:::.       .::.:.|.::....:|::|...|.|.:...:..       .
Worm   213 PIVARMCGCPMDKLKNAHNYACTGTMIFIATYMLYRAPSLIKSTKTALRQIKAVFMV-------H 270

  Fly   298 GLSALIENEWQRLNVPNVLRVFWT--------IRLIQGGYALATTESDEPLDLMTATQKLLVDGC 354
            ||:..:...|::|.:..:|...|.        :.||..|    .|.|:....|:|.    :.:..
Worm   271 GLADGVAVLWRKLRILELLTFTWITMFLMVLYVELIDKG----RTWSEVGRILLTG----VAETT 327

  Fly   355 ETMTAVLGMTGVISMFCHYI---------GRGFQWYLLTYDDEEKSLGTVSAVLFYILALQTGLT 410
            .|...:..:...:|..|.:|         |.....::|.:.      |...||...||.:|||..
Worm   328 NTPITLAALAVSVSYVCKWIADLTKLITGGTRSHGHVLAHS------GYTEAVSVVILCIQTGFL 386

  Fly   411 SLSPDKRFIRLCRNLCLLMTALLHFLHNIVSPILMSLSAARNPSRKRHVRALSVCAFLVVLSVSL 475
            .:..:::.|.|...|.::::|||..|..|:..:|::|.::...||.||.|.:.:...|||:....
Worm   387 GMQVEQKTILLALVLYIVISALLQSLFEIIEVVLLNLPSSPTASRARHARCICIALLLVVIPFFT 451

  Fly   476 LYHLWSQQSISTWLLAVTAFSVEVVVKVLVSLATYTLFLLDARRQFFWEKLDDYLYYVRAFGNSV 540
            ...:.:...|..:...:.|.|..|..:.:..:..|.:.:::.:.:..||.:||..||:......:
Worm   452 TKTMLALLPIDIYTAIIIANSATVTARAIGVILKYIVLIVETKSEEPWEGIDDLTYYIDCANKGI 516

  Fly   541 EFCFGILLFINGAWILIFESAQNATGGGIRAIMMCIHAYFNIWCEARAGWSVFMKRRSAVHKISA 605
            |.....::.:.|...::......||    .||:: .|...||:.......|....|.:||..|:.
Worm   517 ELLAAKVVMVFGCMQVVKVGFSFAT----FAILL-FHVIVNIYKRLEHTVSFIKNRNAAVKNINR 576

  Fly   606 LPEATPAQLQAFDDVCAICYQEM-YSAKITRCRHFFHGVCLRKWLYVQDRCPLCHEIMMYTD--- 666
            |.:|...||:..:||||||:.|| ..|:||.|:|:|||.||||||.|:..||||:..|...|
Worm   577 LSKADVVQLREREDVCAICFIEMKEEARITPCKHYFHGPCLRKWLAVKMVCPLCYTYMKEDDFDS 641

  Fly   667 -----------KADENAPEAEPAPAAQAEQPMRIYPRDDANNAAAQRRSPERAP 709
                       :.:|.....|..|....|||       :|.||       ||||
Worm   642 KSSSSGTLNEVQQNEEGAAVEENPENPEEQP-------EAPNA-------ERAP 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trc8	NP_996303.1	TRC8_N	122..590	CDD:290425	101/503 (20%)
		zf-rbx1	<618..659	CDD:289448	26/41 (63%)
		zf-RING_2	619..659	CDD:290367	26/40 (65%)
rnf-145	NP_491382.2	TRC8_N	49..556	CDD:372682	107/543 (20%)
rnf-145	NP_491382.2	RING-H2_RNF139_like	590..631	CDD:319390	26/40 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I6105
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	145	1.000	Inparanoid score	I3028
Isobase	1	0.950	-	0	Normalized mean entropy	S5880
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D302551at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto17303
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.780