Protein Alignment Trc8 and RNF145

DIOPT Version :10

• Sequence 1: NP_996303.1
• Gene: Trc8 / 43476
• FlyBaseID: FBgn0039668
• Length: 809
• Species: Drosophila melanogaster
• Sequence 2: NP_001186309.1
• Gene: RNF145 / 153830
• HGNCID: 20853
• Length: 693
• Species: Homo sapiens
• Alignment Length: 790
• Identity: 211/790 - (26%)
• Similarity: 346/790 - (43%)
• Gaps: 195/790 - (24%)

  Fly     1 MSVRTKVLGLVDVMMRVPPVMVIDEILKMDMGMQSWLYPDKDKASGALATPTEAPAVPSGQDPFT 65
            |:.:.|:..:::|.:|||.:|::|.:.:.|:
Human    31 MAAKEKLEAVLNVALRVPSIMLLDVLYRWDV---------------------------------- 61

  Fly    66 SIKELFSHMTTSAQSVLEQSIEKASEAAKTHGMLSSGFNSLMNELSKDQTLADVLSTTTVKFVLC 130
                          |...|.|:::|        ||:      |.|.:.:.||  |:...|.::|.
Human    62 --------------SSFFQQIQRSS--------LSN------NPLFQYKYLA--LNMHYVGYILS 96

  Fly   131 VFAFLSAACIFMLWTRHLVMVYM-FLTSLGLTFLSYWSNV-------SALALTERSPSMVEDLMS 187
            |       .:..|..:|||.:|: |||:|    |.|..:.       |.|......|..:|.| |
Human    97 V-------VLLTLPRQHLVQLYLYFLTAL----LLYAGHQISRDYVRSELEFAYEGPMYLEPL-S 149

  Fly   188 LN--TTRLLDSGGVVMSLAPHLMAQWFMGMLFAYIHLGPRFEHVQRSMPIIFASPILLAMLPLPA 250
            :|  ||.|:.. .||.:|...:|....:.:..|:                         ||||.|
Human   150 MNRFTTALIGQ-LVVCTLCSCVMKTKQIWLFSAH-------------------------MLPLLA 188

  Fly   251 KVVQHLPVVAVFTPIILTKITLMQSAMEASRTV-------YN----GYQYAMNFVSNFGLSALIE 304
            :    |.:|.:.|.:|:.|..::.:.:|....:       ||    .|:..:..|..:||.||..
Human   189 R----LCLVPLETIVIINKFAMIFTGLEVLYFLGSNLLVPYNLAKSAYRELVQVVEVYGLLALGM 249

  Fly   305 NEWQRLNVPNVLRVFWTIRLIQGGYALATTESDEPLDLMTATQKLL-------VDGCETMTAVLG 362
            :.|.:|.||.:..|||.:......|:..:|. |:|    .:.::||       .:.|.|..::||
Human   250 SLWNQLVVPVLFMVFWLVLFALQIYSYFSTR-DQP----ASRERLLFLFLTSIAECCSTPYSLLG 309

  Fly   363 MT--------GVISMFCHYIGRGFQWYLLTYDDEEKSLGTVSAVLFYILALQTGLTSLSPDKRFI 419
            :.        ||::: |.:..:|::.::   :|...:.|....|...|||:||||..|....|..
Human   310 LVFTVSFVALGVLTL-CKFYLQGYRAFM---NDPAMNRGMTEGVTLLILAVQTGLIELQVVHRAF 370

  Fly   420 RLCRNLCLLMTALLHFLHNIVSPILMSLSAARNPSRKRHVRALSVCAFLVVLSVSLLYHLWSQQS 484
            .|...|.:::.::|..:..|..||:::|.|:|:.|..:|.||:|:|.||:|....:.|.:.....
Human   371 LLSIILFIVVASILQSMLEIADPIVLALGASRDKSLWKHFRAVSLCLFLLVFPAYMAYMICQFFH 435

  Fly   485 ISTWLLAVTAFSVEVVVKVLVSLATYTLFLLDARRQFFWEKLDDYLYYVRAFGNSVEF------- 542
            :..|||.:.:.|:...::||.:|..|.||:::..|:...|.:||.:|||......:||
Human   436 MDFWLLIIISSSILTSLQVLGTLFIYVLFMVEEFRKEPVENMDDVIYYVNGTYRLLEFLVALCVV 500

  Fly   543 CFGILLFINGAWILIFESAQNATGGGIRAIMMCIHAYFNIWCEARAGWSVFMKRRSAVHKISALP 607
            .:|:...|.|.|.:            :.::::.||:|:|:|..|:.||..|:.||.||:||.:||
Human   501 AYGVSETIFGEWTV------------MGSMIIFIHSYYNVWLRAQLGWKSFLLRRDAVNKIKSLP 553

  Fly   608 EATPAQLQAFDDVCAICYQEMYSAKITRCRHFFHGVCLRKWLYVQDRCPLCHEIMMYTDKADENA 672
            .||..||:..:|:||||||:|.||.||.|.||||..||:||||||:.|||||..:..:.:.....
Human   554 IATKEQLEKHNDICAICYQDMKSAVITPCSHFFHAGCLKKWLYVQETCPLCHCHLKNSSQLPGLG 618

  Fly   673 PEAEPAPAAQAEQPM-----------------RIYPRDDANNAAAQRR--------SPERAPVEA 712
            .|....|.|.|||.:                 ||......||....||        .|:..|..|
Human   619 TEPVLQPHAGAEQNVMFQEGTEPPGQEHTPGTRIQEGSRDNNEYIARRPDNQEGAFDPKEYPHSA 683

  Fly   713 SEQAPATSSS 722
            .::|....|:
Human   684 KDEAHPVESA 693

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trc8	NP_996303.1	TRC8_N	8..590	CDD:463960	147/624 (24%)
		RING-H2_RNF139-like	619..659	CDD:438139	28/39 (72%)
RNF145	NP_001186309.1	TRC8_N	38..536	CDD:463960	147/624 (24%)
		HRD1	<550..>655	CDD:227568	44/104 (42%)
		RING-H2_RNF145	563..605	CDD:319598	28/41 (68%)