DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trc8 and rnf139

DIOPT Version :9

Sequence 1:	NP_996303.1	Gene:	Trc8 / 43476	FlyBaseID:	FBgn0039668	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_001116520.1	Gene:	rnf139 / 100144552	ZFINID:	ZDB-GENE-080401-4	Length:	664	Species:	Danio rerio

Alignment Length:	753	Identity:	251/753 - (33%)
Similarity:	377/753 - (50%)	Gaps:	156/753 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LGLVDVMMRVPPVMVIDEILKMDMGMQSWLYPDKDKASGALATPTEAPAVPSGQDPFTSIKELFS 72
            |.::||::|||.:.:||.||.                              |..||.|.
Zfish    13 LAVLDVVLRVPSIFIIDAILN------------------------------SYSDPGTG------ 41

  Fly    73 HMTTSAQSVLEQSIEKASEAAKTHGMLSSGFNSLMNELSKDQTLADVLSTTTVKFVLCVFAFLSA 137
             .:.:|...|.:::          |::.||                            |...||.
Zfish    42 -WSGAAGRALIRAL----------GIVVSG----------------------------VVLVLSQ 67

  Fly   138 ACIFMLWTRHLVMVYMFLTSLGLTFLSYWSNVSALALTERSPSMVEDLMS-LNTTRLLDSGGVVM 201
            ..:|..:|..:.:    |.......::|::...|            |..| .|:..:|...|..:
Zfish    68 KSLFKFYTLFMAV----LLGAASVLVNYYATAHA------------DFYSAYNSAAVLPRDGPTL 116

  Fly   202 SLAPHLMAQWFMGMLFAYIHLGPRFEHVQRSMPII-FASPILLAMLPLPAKVVQHLPVVAVFTPI 265
            .||..|| |..:|:  .|:.| .|...|..::.:: ..:|:...:|.|||.:.|   |:|:.:.:
Zfish   117 WLALALM-QLLLGL--GYVAL-LRVRSVCAALLLLDIMAPLWGLILELPADMKQ---VLAIASGV 174

  Fly   266 ILTKITLMQSAMEASRTVYN-GYQYAM--NFVSNFGLSALIENEWQRLNVPNVLRVFWTIRLIQG 327
            ||.....:...::.....|: .|.|.:  :....:||..|:|:.|:|:..|::|||||..|:...
Zfish   175 ILATHAALNLLLKLKWFYYSCRYVYLLLRHMYRIYGLQLLLEDTWKRIRFPDILRVFWLTRVTAQ 239

  Fly   328 G----YALATTESDEPLD-----LMTATQKLLVDGCETMTAVLGMTGVISMFCHYIGRGFQWYLL 383
            .    |.:....|:..:.     |...:..|::.||::...||||:.|||...||:|.....::.
Zfish   240 AVILLYVVRVVRSESGMQLGWDVLWDLSSNLIISGCDSTLTVLGMSAVISSLAHYLGLSILAFIG 304

  Fly   384 TYDDEEKSLGTVSAVLFYILALQTGLTSLSPDKRFIRLCRNLCLLMTALLHFLHNIVSPILMSLS 448
            :.::|:|.||.|:.|||:||||||||:.|.|::|.:||.||:|||:||:|||:|.:..|:|||||
Zfish   305 STEEEDKRLGFVAPVLFFILALQTGLSGLDPEERLVRLSRNMCLLLTAILHFIHGMTDPVLMSLS 369

  Fly   449 AARNPSRKRHVRALSVCAFLVVLSVSLLYHLWSQQSISTWLLAVTAFSVEVVVKVLVSLATYTLF 513
            |:...|.:|||..|.|...|..|.|.|.:.||...:::|||.|||||.:|:.:||||||..|.||
Zfish   370 ASHVSSVRRHVPVLLVSLVLFTLPVLLSFLLWHHYALNTWLFAVTAFCIELCLKVLVSLTVYALF 434

  Fly   514 LLDARRQFFWEKLDDYLYYVRAFGNSVEFCFGILLFINGAWILIFESAQNATGGGIRAIMMCIHA 578
            ::|......|||||||:||||:.||.:||.||:::|.|||:.::|||     |..|||.|||:||
Zfish   435 MMDGFYNVLWEKLDDYVYYVRSTGNVIEFIFGVIMFGNGAYTMMFES-----GSKIRACMMCLHA 494

  Fly   579 YFNIWCEARAGWSVFMKRRSAVHKISALPEATPAQLQAFDDVCAICYQEM-YSAKITRCRHFFHG 642
            ||||:.:|:.||..|:.||:||.||::|||...::|:..:|||||||||. .||:||.|.|:||.
Zfish   495 YFNIYLQAKNGWKTFINRRTAVKKINSLPEVRGSRLRDIEDVCAICYQEFGSSARITPCSHYFHA 559

  Fly   643 VCLRKWLYVQDRCPLCHEIMMYTDKADENAPEAEPAPAAQAEQPMRIYPRDD-------ANNAAA 700
            :|||||||:||.||:||:                           |:|..||       :||...
Zfish   560 LCLRKWLYIQDTCPMCHQ---------------------------RVYIEDDTSERSTFSNNNGY 597

  Fly   701 QRRSPERAPVEASEQAPATSSSSAAATIGAEAVSAIVE 738
            .....|||..|.:|    ..:....|..|||..:.::|
Zfish   598 GAAGQERAEFEENE----GGAEDGVAAAGAEPENELLE 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trc8	NP_996303.1	TRC8_N	122..590	CDD:290425	173/481 (36%)
		zf-rbx1	<618..659	CDD:289448	28/41 (68%)
		zf-RING_2	619..659	CDD:290367	28/40 (70%)
rnf139	NP_001116520.1	TRC8_N	13..506	CDD:290425	192/595 (32%)
		zf-rbx1	516..576	CDD:289448	35/59 (59%)
		RING	537..579	CDD:238093	28/68 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587040
Domainoid	1	1.000	288	1.000	Domainoid score	I1531
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5222
Inparanoid	1	1.050	383	1.000	Inparanoid score	I2000
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D302551at33208
OrthoFinder	1	1.000	-	-		FOG0008390
OrthoInspector	1	1.000	-	-		oto39599
orthoMCL	1	0.900	-	-		OOG6_108947
Panther	1	1.100	-	-	LDO	PTHR22763
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6571
SonicParanoid	1	1.000	-	-		X6380
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.930