DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FipoQ and Fbxl20

DIOPT Version :9

Sequence 1:	NP_733291.1	Gene:	FipoQ / 43475	FlyBaseID:	FBgn0039667	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	XP_006534361.1	Gene:	Fbxl20 / 72194	MGIID:	1919444	Length:	438	Species:	Mus musculus

Alignment Length:	456	Identity:	102/456 - (22%)
Similarity:	170/456 - (37%)	Gaps:	159/456 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 EKLPDKVLLHIFSYLSHREICRLARICRRWRQIAYDTRLWKNVSL---RPEVSGLHVGSLEMLLQ 96
            :|||.::||.|||:|....:||.|::.|.|..:|.|...|:.:.|   :.::.|
Mouse    28 KKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEG----------- 81

  Fly    97 LISVRFGPTLRYIELPIELITHTVLHELSAKCPNLTHMLLDFSTAMQLHDFSEMQAFPTKLRYMC 161
                                  .|:..:|.:|
Mouse    82 ----------------------RVVENISKRC--------------------------------- 91

  Fly   162 VCLSEVIFMEGFMRKIYNFINGLEVLHLIGTYEKCEEEEEEIYEVINVHKLKSATPNLRVINLYG 226
                     .||:||                                             ::|.|
Mouse    92 ---------GGFLRK---------------------------------------------LSLRG 102

  Fly   227 INFIDDSHIDAFSSNCIQLECLAVNFCNKVTGSTLKTLIQRSKRL------TCLLMNGTSLKSEF 285
            ...:.|:.:..|:.||..:|.|::|.|.|.|.:|..:|.:...:|      :|..:...|||
Mouse   103 CLGVGDNALRTFAQNCRNIEVLSLNGCTKTTDATCTSLSKFCSKLRHLDLASCTSITNMSLK--- 164

  Fly   286 VMQAEWDKC-ALQELDITATDLSTECLVDMLSR-IPSLKFLSAGQINGFNDSVLKQWMESGTTRS 348
               |..:.| .|::|:|:..|..|:..:..|.| ...||.|.........|..||  ........
Mouse   165 ---ALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALK--YIGAHCPE 224

  Fly   349 LISLDLDSSDNISDEGLLKFIQRQGHQLSACCLSGMPHITDQLWMSILPLLG-NC---KIIVMGT 409
            |::|:|.:...|:||||:. |.|..|:|.:.|.||..:|||    :||..|| ||   :|:.:..
Mouse   225 LVTLNLQTCLQITDEGLIT-ICRGCHKLQSLCASGCSNITD----AILNALGQNCPRLRILEVAR 284

  Fly   410 AEKLGVNIHVDQLMDTIASNCGNLERLELRWDPDNLRFSDKS--QKAIDILRVKCLKL-RCMVLS 471
            ..:|     .|....|:|.||..||:::|.   :.::.:|.:  |.:|...|::.|.| .|.:::
Mouse   285 CSQL-----TDVGFTTLARNCHELEKMDLE---ECVQITDSTLIQLSIHCPRLQVLSLSHCELIT 341

  Fly   472 D 472
            |
Mouse   342 D 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FipoQ	NP_733291.1	F-box-like	34..80	CDD:289689	18/47 (38%)
		leucine-rich repeat	131..156	CDD:275381	0/24 (0%)
		leucine-rich repeat	157..175	CDD:275381	2/17 (12%)
		leucine-rich repeat	219..244	CDD:275381	6/24 (25%)
		leucine-rich repeat	245..270	CDD:275381	8/24 (33%)
		leucine-rich repeat	271..295	CDD:275381	7/30 (23%)
		leucine-rich repeat	296..320	CDD:275381	7/24 (29%)
		leucine-rich repeat	321..348	CDD:275381	6/26 (23%)
		leucine-rich repeat	349..375	CDD:275381	10/25 (40%)
		leucine-rich repeat	376..403	CDD:275381	13/30 (43%)
		leucine-rich repeat	405..432	CDD:275381	6/26 (23%)
Fbxl20	XP_006534361.1	F-box-like	30..71	CDD:403981	16/40 (40%)
		leucine-rich repeat	67..94	CDD:275381	6/101 (6%)
		AMN1	95..291	CDD:187754	62/258 (24%)
		leucine-rich repeat	95..114	CDD:275381	5/63 (8%)
		leucine-rich repeat	121..146	CDD:275381	8/24 (33%)
		leucine-rich repeat	147..172	CDD:275381	7/30 (23%)
		leucine-rich repeat	173..198	CDD:275381	7/24 (29%)
		leucine-rich repeat	199..224	CDD:275381	6/26 (23%)
		AMN1	222..396	CDD:187754	42/134 (31%)
		leucine-rich repeat	225..250	CDD:275381	10/25 (40%)
		leucine-rich repeat	251..276	CDD:275381	13/28 (46%)
		leucine-rich repeat	277..302	CDD:275381	7/29 (24%)
		leucine-rich repeat	303..328	CDD:275381	6/27 (22%)
		leucine-rich repeat	329..357	CDD:275381	4/14 (29%)
		leucine-rich repeat	358..382	CDD:275381
		leucine-rich repeat	383..408	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843137
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840