DRSC/TRiP Functional Genomics Resources

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Protein Alignment FipoQ and SKP2

DIOPT Version :9

Sequence 1:NP_733291.1 Gene:FipoQ / 43475 FlyBaseID:FBgn0039667 Length:515 Species:Drosophila melanogaster
Sequence 2:NP_005974.2 Gene:SKP2 / 6502 HGNCID:10901 Length:424 Species:Homo sapiens


Alignment Length:343 Identity:72/343 - (20%)
Similarity:133/343 - (38%) Gaps:110/343 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 RSPFADTTIEKLPDKVLLHIFSYLSHREICRLARICRRWRQIAYDTRLWKNV-----SLRPEVSG 85
            |..|...:.:.|||::||.|||.|...|:.:::.:|:||.::|.|..||:.:     :|.|:|:|
Human    89 RENFPGVSWDSLPDELLLGIFSCLCLPELLKVSGVCKRWYRLASDESLWQTLDLTGKNLHPDVTG 153

  Fly    86 --LHVGSL------EMLLQLISVRFGP-TLRYIELPIELITHTVLHELSAKCPNLTHMLLDFSTA 141
              |..|.:      ..:.|.::..|.| .:::::|...:|..:.||.:.::|..|.::.|:   .
Human   154 RLLSQGVIAFRCPRSFMDQPLAEHFSPFRVQHMDLSNSVIEVSTLHGILSQCSKLQNLSLE---G 215

  Fly   142 MQLHDFSEMQAFPTKLRYMCVCLSEVIFMEGFMRKIYNFINGLEVLHLIGTYEKCEEEEEEIYEV 206
            ::|.|                                         .::.|..|           
Human   216 LRLSD-----------------------------------------PIVNTLAK----------- 228

  Fly   207 INVHKLKSATPNLRVINLYGINFIDDSHIDAFSSNCIQLECLAVNFC------------------ 253
                     ..||..:||.|.:...:..:....|:|.:|:.|.:::|                  
Human   229 ---------NSNLVRLNLSGCSGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSET 284

  Fly   254 ----------NKVTGSTLKTLIQRSKRLTCL-LMNGTSLKSEFVMQAEWDKCALQELDIT-ATDL 306
                      ..:..|.|.||::|...|..| |.:...||:: ..|..:....||.|.:: ..|:
Human   285 ITQLNLSGYRKNLQKSDLSTLVRRCPNLVHLDLSDSVMLKND-CFQEFFQLNYLQHLSLSRCYDI 348

  Fly   307 STECLVDMLSRIPSLKFL 324
            ..|.|:: |..||:||.|
Human   349 IPETLLE-LGEIPTLKTL 365

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FipoQNP_733291.1 F-box-like 34..80 CDD:289689 17/50 (34%)
leucine-rich repeat 131..156 CDD:275381 4/24 (17%)
leucine-rich repeat 157..175 CDD:275381 0/17 (0%)
leucine-rich repeat 219..244 CDD:275381 6/24 (25%)
leucine-rich repeat 245..270 CDD:275381 8/52 (15%)
leucine-rich repeat 271..295 CDD:275381 6/24 (25%)
leucine-rich repeat 296..320 CDD:275381 8/24 (33%)
leucine-rich repeat 321..348 CDD:275381 3/4 (75%)
leucine-rich repeat 349..375 CDD:275381
leucine-rich repeat 376..403 CDD:275381
leucine-rich repeat 405..432 CDD:275381
SKP2NP_005974.2 Mediates interaction with hepatitis C virus non-structural protein NS5A. /evidence=ECO:0000269|PubMed:27194766 1..220 36/133 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 39..73
Nuclear localization signal. /evidence=ECO:0000269|PubMed:22770219 67..73
F-box-like 97..141 CDD:403981 17/43 (40%)
leucine-rich repeat 183..207 CDD:275381 5/23 (22%)
AMN1 193..>345 CDD:187754 34/216 (16%)
leucine-rich repeat 208..231 CDD:275381 6/86 (7%)
LRR 3. /evidence=ECO:0000269|PubMed:11099048 210..234 7/87 (8%)
leucine-rich repeat 232..257 CDD:275381 6/24 (25%)
LRR 4. /evidence=ECO:0000269|PubMed:11099048 235..257 5/21 (24%)
leucine-rich repeat 258..284 CDD:275381 3/25 (12%)
LRR 5. /evidence=ECO:0000269|PubMed:11099048 258..284 3/25 (12%)
leucine-rich repeat 285..311 CDD:275381 5/25 (20%)
LRR 6. /evidence=ECO:0000269|PubMed:11099048 286..308 4/21 (19%)
LRR 7. /evidence=ECO:0000269|PubMed:11099048 309..330 5/21 (24%)
leucine-rich repeat 312..336 CDD:275381 6/24 (25%)
LRR 8. /evidence=ECO:0000269|PubMed:11099048 334..356 6/22 (27%)
leucine-rich repeat 337..356 CDD:275381 6/19 (32%)
LRR 9. /evidence=ECO:0000269|PubMed:11099048 359..378 5/7 (71%)
leucine-rich repeat 365..392 CDD:275381 1/1 (100%)
LRR 10. /evidence=ECO:0000269|PubMed:11099048 380..401
Mediates interaction with IFI27. /evidence=ECO:0000269|PubMed:27194766 402..424
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165152993
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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