DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FipoQ and Fbxl3

DIOPT Version :9

Sequence 1:	NP_733291.1	Gene:	FipoQ / 43475	FlyBaseID:	FBgn0039667	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_001347270.1	Gene:	Fbxl3 / 50789	MGIID:	1354702	Length:	428	Species:	Mus musculus

Alignment Length:	325	Identity:	61/325 - (18%)
Similarity:	116/325 - (35%)	Gaps:	86/325 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 EASQVYLSDGTVRSPFADTTIEK---------LPDKVLLHIFSYLSHREICRLARICRRWRQIAY 69
            ::.|....:||...|....|.::         |...::||:|.||...:....:::||.|.|:.:
Mouse     7 DSDQDSAEEGTAEKPKRPRTTQERSQPCDWGNLLQDIVLHVFKYLPLLDRAHASQVCRNWNQVFH 71

  Fly    70 DTRLWKNVSL---RPEVSGLHVGSLEMLLQLISVRFGPTLRYIELPIELITHTVLHELSAKCPNL 131
            ...||:....   :|..|.|.....|::.|:|. |....|:|:...::    :......|.|..|
Mouse    72 MPDLWRCFEFELNQPATSYLKATHPELIKQIIK-RHSNHLQYVSFKVD----SSKESAEAACDIL 131

  Fly   132 THMLLDFSTAMQLHDFSEMQAFPTKLRYMCVCLSEVIFMEGFMRKIYNFINGLEVLHLIGTYEKC 196
            :.::......:.|                 :..:...||:  :.|.: ||:.|.|:
Mouse   132 SQLVNCSLKTLGL-----------------ISTARPSFMD--LPKSH-FISALTVV--------- 167

  Fly   197 EEEEEEIYEVINVHKLKSATPNLRVINLYGINFIDDSHID------AFSSNCIQLECLAVNFCNK 255
                     .:|...|.|..             |||:.:|      ..::|...|:.|.::.|..
Mouse   168 ---------FVNSKSLSSLK-------------IDDTPVDDPSLKVLVANNSDTLKLLKMSSCPH 210

  Fly   256 VTGSTLKTLIQRSKRLTCLLMNGTSLKSEFVMQAEWDK-CALQELDITATDLSTECLVDMLSRIP 319
            |:.:.:..:..:...|..|.:|...|..|.::....:| ..|:.|.|           |::|..|
Mouse   211 VSPAGILCVADQCHGLRELALNYHLLSDELLLALSSEKHVRLEHLRI-----------DVVSENP 264

Fly 320 319
Mouse 265 264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FipoQ	NP_733291.1	F-box-like	34..80	CDD:289689	12/57 (21%)
		leucine-rich repeat	131..156	CDD:275381	2/24 (8%)
		leucine-rich repeat	157..175	CDD:275381	2/17 (12%)
		leucine-rich repeat	219..244	CDD:275381	5/30 (17%)
		leucine-rich repeat	245..270	CDD:275381	4/24 (17%)
		leucine-rich repeat	271..295	CDD:275381	6/24 (25%)
		leucine-rich repeat	296..320	CDD:275381	6/24 (25%)
		leucine-rich repeat	321..348	CDD:275381
		leucine-rich repeat	349..375	CDD:275381
		leucine-rich repeat	376..403	CDD:275381
		leucine-rich repeat	405..432	CDD:275381
Fbxl3	NP_001347270.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		5/25 (20%)
		F-box-like	36..77	CDD:315592	11/40 (28%)
		LRR 1	119..146		4/43 (9%)
		leucine-rich repeat	174..199	CDD:275381	7/37 (19%)
		LRR 2	181..207		5/25 (20%)
		leucine-rich repeat	200..225	CDD:275381	4/24 (17%)
		LRR 3	208..233		4/24 (17%)
		LRR 4	234..259		6/35 (17%)
		leucine-rich repeat	252..286	CDD:275381	6/24 (25%)
		leucine-rich repeat	287..333	CDD:275381
		LRR 5	316..341
		leucine-rich repeat	334..360	CDD:275381
		LRR 6	343..368
		leucine-rich repeat	361..383	CDD:275381
		LRR 7	369..394
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843126
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1027299at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840