DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FipoQ and Fbxl17

DIOPT Version :9

Sequence 1:	NP_733291.1	Gene:	FipoQ / 43475	FlyBaseID:	FBgn0039667	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_056609.1	Gene:	Fbxl17 / 50758	MGIID:	1354704	Length:	701	Species:	Mus musculus

Alignment Length:	427	Identity:	98/427 - (22%)
Similarity:	178/427 - (41%)	Gaps:	69/427 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 IEKLPDKVLLHIFSYLSHREICRLAR-ICRRWRQIAYDTRLWKNVSL--RPEVSGLHVGSLEMLL 95
            |.:||..:||.|||.||..|.|..|. :|:.||.:..|.:.||.:.|  |.:|:       :.||
Mouse   321 INQLPPSILLKIFSNLSLNERCLSASLVCKYWRDLCLDFQFWKQLDLSSRQQVT-------DELL 378

  Fly    96 QLISVRFGPTLRYIELPI---ELITHTVLHELSAKCPNLTHMLLDFSTAMQLHDFSEMQAFPTKL 157
            :.|:.|   :...||:.|   ..::.:.:..|:.|||.|...     ||
Mouse   379 EKIASR---SQNIIEINISDCRSLSDSGVCVLAFKCPGLLRY-----TA---------------- 419

  Fly   158 RYMCVCLSEVIFMEGFMRKIYNFINGLEVLHLIGTYEKCEEEEEEIYEVINVHKLKSATPNLRVI 222
             |.|..||:...:     .:.:....|:.:| :|..:|..:|        .:.:|.|....|:.|
Mouse   420 -YRCKQLSDTSII-----AVASHCPLLQKVH-VGNQDKLTDE--------GLKQLGSRCRELKDI 469

  Fly   223 NLYGINFIDDSHIDAFSSNCIQLECLAVNFCNKVTGSTLKTLIQRSKRLTCLLMNGTSLKSEFVM 287
            :......|.|..:...:.:|::|:.:.:.....||..::|...:....|..:...|.|:.|:.|:
Mouse   470 HFGQCYKISDEGMIVIAKSCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGCSVTSKGVI 534

  Fly   288 QAEWDKCALQELDIT-ATDLSTECLVDMLSRIPSLKFLSAGQINGFNDSVLKQWMESGTTRSLIS 351
            .....: .|..||:. .|:|..|.:::::.|..:|..|:.......||..::...:.|  ::|..
Mouse   535 HLTKLR-NLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKEG--QNLKE 596

  Fly   352 LDLDSSDNISDEGLLKFIQRQGHQLSACCLSGMPHITDQLWMSILPLLGNCKIIVMGTAEKLGVN 416
            |.|.|. .|:|..|:. |.|....:....:.....||||....|.....:.:.:.:...:|:. .
Mouse   597 LYLVSC-KITDYALIA-IGRYSVTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVN-E 658

  Fly   417 IHVDQLM--------DTIASNC-GNLER-LELRWDPD 443
            :.|:||:        .|:..:| ..||| .::.|.|:
Mouse   659 LTVEQLVQQYPHITFSTVLQDCKRTLERAYQMGWTPN 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FipoQ	NP_733291.1	F-box-like	34..80	CDD:289689	20/48 (42%)
		leucine-rich repeat	131..156	CDD:275381	3/24 (13%)
		leucine-rich repeat	157..175	CDD:275381	4/17 (24%)
		leucine-rich repeat	219..244	CDD:275381	5/24 (21%)
		leucine-rich repeat	245..270	CDD:275381	4/24 (17%)
		leucine-rich repeat	271..295	CDD:275381	5/23 (22%)
		leucine-rich repeat	296..320	CDD:275381	7/24 (29%)
		leucine-rich repeat	321..348	CDD:275381	5/26 (19%)
		leucine-rich repeat	349..375	CDD:275381	9/25 (36%)
		leucine-rich repeat	376..403	CDD:275381	5/26 (19%)
		leucine-rich repeat	405..432	CDD:275381	6/35 (17%)
Fbxl17	NP_056609.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	73..93
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	227..250
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	279..321		98/427 (23%)
		F-box-like	321..368	CDD:289689	19/46 (41%)
		leucine-rich repeat	362..387	CDD:275381	9/34 (26%)
		leucine-rich repeat	388..413	CDD:275381	6/24 (25%)
		AMN1	411..573	CDD:187754	39/198 (20%)
		leucine-rich repeat	414..439	CDD:275381	7/51 (14%)
		leucine-rich repeat	440..465	CDD:275381	7/33 (21%)
		leucine-rich repeat	466..491	CDD:275381	5/24 (21%)
		leucine-rich repeat	492..517	CDD:275381	4/24 (17%)
		leucine-rich repeat	545..567	CDD:275381	6/21 (29%)
		leucine-rich repeat	568..593	CDD:275381	5/26 (19%)
		leucine-rich repeat	594..618	CDD:275381	9/25 (36%)
		leucine-rich repeat	619..644	CDD:275381	5/24 (21%)
		leucine-rich repeat	645..670	CDD:275381	4/25 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843131
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740