DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FipoQ and Fbxl7

DIOPT Version :9

Sequence 1:	NP_733291.1	Gene:	FipoQ / 43475	FlyBaseID:	FBgn0039667	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_795933.2	Gene:	Fbxl7 / 448987	MGIID:	3052506	Length:	491	Species:	Mus musculus

Alignment Length:	386	Identity:	83/386 - (21%)
Similarity:	146/386 - (37%)	Gaps:	134/386 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 TIEKLPDKVLLHIFSYLSHREICRLARICRRWRQIAYDTRLWKNVSL------------------ 79
            :|::|||..::.|||:|...::||.||:||||..:|:|.|||:.:.|
Mouse   113 SIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRRL 177

  Fly    80 --------------------------------------RPEVSGLHVGSLEMLLQLI-------- 98
                                                  |.||||.:..|.|.:..::
Mouse   178 CQDTPNVCLMLETVIVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEH 242

  Fly    99 ------------------SVRFGP------TLRYIEL-PIELITHTVLHELSAKCPNLTHMLLDF 138
                              |::..|      ::||::: ...::....||.::|.|..|||:.|
Mouse   243 LDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYL-- 305

  Fly   139 STAMQLHDFSEMQAFPTKLRYMCV-C-------LSEVIFMEGF----MRKIYNFINGLEVLHLIG 191
            ...::|.|        ..|||:.: |       :|:..|:..|    :.|:.:.:..|.:.|
Mouse   306 RRCVRLTD--------EGLRYLVIYCTSIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAH--- 359

  Fly   192 TYEKCEEEEEEIYEVINVHKLKSATPNLRVINLYGINFIDDSHIDAFSSNCIQLECLAVNFCNKV 256
                |....:     :.:..:......||.:|..|...|.|..::..:.||.:|:.|.:..|..|
Mouse   360 ----CGRITD-----VGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLV 415

  Fly   257 TGSTLKTLIQRSKRLTCLLMNGTSLKS-EFV----MQAEWDKC-ALQELDITATDLSTECL 311
            :.:.|::|     .|.|..:...|||| |.:    :|.....| .||.|::...::|.|.|
Mouse   416 SDTGLESL-----ALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQMLNVQDCEVSVEAL 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FipoQ	NP_733291.1	F-box-like	34..80	CDD:289689	22/101 (22%)
		leucine-rich repeat	131..156	CDD:275381	6/24 (25%)
		leucine-rich repeat	157..175	CDD:275381	7/29 (24%)
		leucine-rich repeat	219..244	CDD:275381	8/24 (33%)
		leucine-rich repeat	245..270	CDD:275381	6/24 (25%)
		leucine-rich repeat	271..295	CDD:275381	9/29 (31%)
		leucine-rich repeat	296..320	CDD:275381	6/16 (38%)
		leucine-rich repeat	321..348	CDD:275381
		leucine-rich repeat	349..375	CDD:275381
		leucine-rich repeat	376..403	CDD:275381
		leucine-rich repeat	405..432	CDD:275381
Fbxl7	NP_795933.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..79
		F-box-like	114..160	CDD:289689	21/45 (47%)
		leucine-rich repeat	129..151	CDD:275381	10/21 (48%)
		leucine-rich repeat	154..187	CDD:275381	2/32 (6%)
		AMN1	<185..366	CDD:187754	32/202 (16%)
		LRR 1	185..210		0/24 (0%)
		leucine-rich repeat	188..213	CDD:275381	0/24 (0%)
		LRR 2	211..236		7/24 (29%)
		leucine-rich repeat	214..234	CDD:275381	7/19 (37%)
		LRR 3	237..262		0/24 (0%)
		leucine-rich repeat	240..273	CDD:275381	2/32 (6%)
		LRR 4	271..296		4/24 (17%)
		leucine-rich repeat	274..299	CDD:275381	6/24 (25%)
		AMN1	297..464	CDD:187754	44/193 (23%)
		LRR 5	297..322		10/34 (29%)
		leucine-rich repeat	300..325	CDD:275381	10/34 (29%)
		LRR 6	323..348		4/24 (17%)
		leucine-rich repeat	326..351	CDD:275381	4/24 (17%)
		LRR 7	349..374		3/36 (8%)
		leucine-rich repeat	352..377	CDD:275381	3/36 (8%)
		LRR 8	375..400		6/24 (25%)
		leucine-rich repeat	378..403	CDD:275381	8/24 (33%)
		LRR 9	401..426		7/29 (24%)
		leucine-rich repeat	404..429	CDD:275381	8/29 (28%)
		LRR 10	427..452		7/24 (29%)
		leucine-rich repeat	430..453	CDD:275381	6/22 (27%)
		leucine-rich repeat	456..480	CDD:275381	6/16 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843166
Domainoid	1	1.000	59	1.000	Domainoid score	I10630
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1027299at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750