DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FipoQ and fbxl2

DIOPT Version :9

Sequence 1:	NP_733291.1	Gene:	FipoQ / 43475	FlyBaseID:	FBgn0039667	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_956400.1	Gene:	fbxl2 / 378737	ZFINID:	ZDB-GENE-030925-12	Length:	432	Species:	Danio rerio

Alignment Length:	487	Identity:	107/487 - (21%)
Similarity:	189/487 - (38%)	Gaps:	148/487 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 EKLPDKVLLHIFSYLSHREICRLARICRRWRQIAYDTRLWKNVSL---RPEVSGLHVGSLEMLLQ 96
            :|||.::||.|||||....:||.|::.:.|..:|.|...|:.:.|   :.::.|       .:::
Zfish    22 KKLPKELLLRIFSYLDVVTLCRCAQVSKAWNVLALDGSNWQKIDLFNFQTDIEG-------RVVE 79

  Fly    97 LISVRFGPTLRYIELPIEL-ITHTVLHELSAKCPNLTHMLLDFSTAMQLHDFSEMQAFPTKLRYM 160
            .||.|.|..||.:.|...| :....:...:..|.|:.|:.|:..|  ::.|.:
Zfish    80 NISKRCGGFLRQLSLRGCLSVGDASMKTFAQNCRNIEHLNLNGCT--KITDST------------ 130

  Fly   161 CVCLSEVIFMEGFMRKIYNFINGLEVLHLIGTYEKCEEEEEEIYEVINVHKLKSATPNLRVINLY 225
            |:.||:..|                                                .||.::|.
Zfish   131 CISLSKFCF------------------------------------------------KLRHLDLT 147

  Fly   226 GINFIDDSHIDAFSSNCIQLECLAVNFCNKVTGSTLKTLIQRSKRLTCLLMNGTSLKSEFVMQAE 290
            ....|.:..:.|.|..|..||.|.:::|:::|...::.|.:....|..|.:.|.:
Zfish   148 SCVSITNHALKALSEGCRMLENLNLSWCDQITSDGIEALSRGCTALRALFLRGCT---------- 202

  Fly   291 WDKCALQELDITATDLSTECLVDMLSRIPSLKFLSAGQINGFNDSVLKQWMESGTTRSLISLDLD 355
                   :||.||                 ||.|.            |...|      |:::::.
Zfish   203 -------QLDDTA-----------------LKHLQ------------KHCPE------LMTINMQ 225

  Fly   356 SSDNISDEGLLKFIQRQGHQLSACCLSGMPHITDQLWMSILPLLG-NCKIIVMGTAEKLGVNIHV 419
            |...|:|:|.:. :.|..|:|...|:||..:|||    :.|..|| ||:.:.:..|.:..   ||
Zfish   226 SCTQITDDGFVS-LCRGCHKLQMVCISGCSNITD----ASLTALGLNCQRLKILEAARCS---HV 282

  Fly   420 -DQLMDTIASNCGNLERLELRWDPDNLRFSDKS--QKAIDILRVKCLKL-RCMVLSDG--RYYET 478
             |.....:|.||..:|:::|.   :.:..:|.:  |.:|...|::.|.| .|.:::|.  |:..:
Zfish   283 TDAGFTVLARNCHEMEKMDLE---ECILVTDNTLVQLSIHCPRLQALSLSHCELITDDGIRHLSS 344

  Fly   479 VKANFERADRITVVRTTTCCRVSPYHL--LRN 508
            .....|   |:.||....|..::...|  |:|
Zfish   345 SVCGQE---RLQVVELDNCPLITDITLEHLKN 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FipoQ	NP_733291.1	F-box-like	34..80	CDD:289689	18/47 (38%)
		leucine-rich repeat	131..156	CDD:275381	4/24 (17%)
		leucine-rich repeat	157..175	CDD:275381	4/17 (24%)
		leucine-rich repeat	219..244	CDD:275381	7/24 (29%)
		leucine-rich repeat	245..270	CDD:275381	6/24 (25%)
		leucine-rich repeat	271..295	CDD:275381	3/23 (13%)
		leucine-rich repeat	296..320	CDD:275381	4/23 (17%)
		leucine-rich repeat	321..348	CDD:275381	5/26 (19%)
		leucine-rich repeat	349..375	CDD:275381	6/25 (24%)
		leucine-rich repeat	376..403	CDD:275381	11/27 (41%)
		leucine-rich repeat	405..432	CDD:275381	7/27 (26%)
fbxl2	NP_956400.1	F-box-like	24..66	CDD:289689	16/41 (39%)
		leucine-rich repeat	61..88	CDD:275381	7/33 (21%)
		AMN1	63..284	CDD:187754	67/349 (19%)
		leucine-rich repeat	89..108	CDD:275381	4/18 (22%)
		leucine-rich repeat	115..140	CDD:275381	8/86 (9%)
		leucine-rich repeat	141..166	CDD:275381	7/24 (29%)
		leucine-rich repeat	167..192	CDD:275381	6/24 (25%)
		leucine-rich repeat	193..218	CDD:275381	11/70 (16%)
		AMN1	212..390	CDD:187754	48/194 (25%)
		leucine-rich repeat	219..244	CDD:275381	6/25 (24%)
		leucine-rich repeat	245..270	CDD:275381	12/28 (43%)
		leucine-rich repeat	271..296	CDD:275381	7/27 (26%)
		leucine-rich repeat	297..322	CDD:275381	5/27 (19%)
		leucine-rich repeat	323..351	CDD:275381	6/30 (20%)
		leucine-rich repeat	352..376	CDD:275381	6/22 (27%)
		leucine-rich repeat	377..402	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588065
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840