DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FipoQ and fbxl5

DIOPT Version :9

Sequence 1:	NP_733291.1	Gene:	FipoQ / 43475	FlyBaseID:	FBgn0039667	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_001288257.1	Gene:	fbxl5 / 322181	ZFINID:	ZDB-GENE-030131-900	Length:	679	Species:	Danio rerio

Alignment Length:	554	Identity:	97/554 - (17%)
Similarity:	171/554 - (30%)	Gaps:	244/554 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 TIEKLPDKVLLHIFSYLSHREICRLARICRRWRQIAYDTRLWK------------------NVSL 79
            ::..||.::||.||.:|..:::||.|::|..|.|:.....||:                  ::.|
Zfish   207 SVSSLPQELLLRIFRFLGPQDLCRCAQVCSVWTQVTRTGSLWRHLYPVRWARGEYYSGPPGDLDL 271

  Fly    80 RPE-----------------------------------VSGLHVGSLEM--LLQLISVRFGPTLR 107
            .|:                                   :|.|....|.:  ::|.:....|.::|
Zfish   272 EPDDDWIKSLQDDGRAYQEWDEDADVDESEEASAERSSISALQREKLLLNGIIQKLLPAVGSSVR 336

  Fly   108 YIELPI-ELITHTVLHELSAKCPNLTHMLLDFSTAMQLHDFSEMQAFPTKLRYMC---VCLSEVI 168
            .:.|.. ..::..::.::.:.||||||:           |.::.....:.....|   .|
Zfish   337 SLSLAYSSTLSSKMVRQMLSLCPNLTHL-----------DLTQTDVSDSAFDSWCALGAC----- 385

  Fly   169 FMEGFMRKIYNFINGLEVLHLIGTYEKCEEEEEEIYEVINV-----------HKLKSATPN-LRV 221
                         ..|:.|.|.|    |::..:...::::|           |||..|.|: :|
Zfish   386 -------------GTLQHLDLSG----CDKITDRTLKILSVGLGDSSTPSPAHKLLQAPPSPIR- 432

  Fly   222 INLYGINFIDDSHIDAFSSNCIQL----------------------------------------- 245
                    |::..:.....:|..|
Zfish   433 --------IEEPRLQPMGRSCQDLIFKRRPGGRGSGCGPTHIWVLDPVKLADIEDAADWSRRGGV 489

  Fly   246 -----------ECLAVNFCNKVTGSTLKTLIQRSKRLTCLLMNG--TSLKSEFVMQAEW------ 291
                       |.|:.:.|           .:||:|      .|  |.|.|     :.|
Zfish   490 ASQEIGCGGISEALSASCC-----------CRRSQR------RGFRTGLSS-----SPWQYGDAL 532

  Fly   292 ---------DKCALQ-ELDITAT----DLSTECLVDMLSRIPSLKFLSAGQINGFNDSVLKQWME 342
                     |..||: :.|:.||    :|.|:|.         .:..|..:.:...|       :
Zfish   533 CGHSSCCSSDAAALRTQSDLQATGGSAELRTKCW---------FEGQSCAEHHNRTD-------Q 581

  Fly   343 SGTTRSLISLDLDSSDNISDEGLLKFIQRQGHQLSACCLSGMPHITDQLWMSILPLLGNCKIIVM 407
            ||..|:|..|.|.....|:|.||          ...|...|:| :.:.|.:|..||:....:..:
Zfish   582 SGAQRALRFLSLSGCHQITDLGL----------RCVCLRGGLP-LLEHLNLSGCPLITGAGLQEV 635

  Fly   408 GTAEKLGVNIHVDQLMDTI-------ASNCGNLE 434
            .:|.. .:||......|.|       ||.|.||:
Zfish   636 VSASP-ALNIEHFYYCDNINGPHADTASGCQNLQ 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FipoQ	NP_733291.1	F-box-like	34..80	CDD:289689	15/63 (24%)
		leucine-rich repeat	131..156	CDD:275381	4/24 (17%)
		leucine-rich repeat	157..175	CDD:275381	2/20 (10%)
		leucine-rich repeat	219..244	CDD:275381	3/24 (13%)
		leucine-rich repeat	245..270	CDD:275381	6/76 (8%)
		leucine-rich repeat	271..295	CDD:275381	6/40 (15%)
		leucine-rich repeat	296..320	CDD:275381	7/28 (25%)
		leucine-rich repeat	321..348	CDD:275381	4/26 (15%)
		leucine-rich repeat	349..375	CDD:275381	7/25 (28%)
		leucine-rich repeat	376..403	CDD:275381	7/26 (27%)
		leucine-rich repeat	405..432	CDD:275381	8/33 (24%)
fbxl5	NP_001288257.1	Hemerythrin-like. /evidence=ECO:0000250	1..159
		Hr_FBXL5	7..155	CDD:213984
		F-box-like	208..252	CDD:289689	15/43 (35%)
		AMN1	313..>410	CDD:187754	20/129 (16%)
		LRR 1	316..342		5/25 (20%)
		leucine-rich repeat	335..360	CDD:275381	3/24 (13%)
		LRR 2	343..367		7/34 (21%)
		leucine-rich repeat	361..387	CDD:275381	6/54 (11%)
		LRR 3	368..395		5/44 (11%)
		leucine-rich repeat	388..422	CDD:275381	6/37 (16%)
		LRR 4	396..426		5/29 (17%)
		leucine-rich repeat	423..447	CDD:275381	6/32 (19%)
		leucine-rich repeat	510..574	CDD:275381	18/83 (22%)
		LRR 5	565..595		9/45 (20%)
		AMN1	566..>644	CDD:187754	20/105 (19%)
		leucine-rich repeat	588..615	CDD:275381	10/37 (27%)
		LRR 6	596..623		8/37 (22%)
		leucine-rich repeat	616..641	CDD:275381	5/25 (20%)
		LRR 7	624..649		5/25 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588074
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840