DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FipoQ and Fbxl6

DIOPT Version :9

Sequence 1:	NP_733291.1	Gene:	FipoQ / 43475	FlyBaseID:	FBgn0039667	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_038937.2	Gene:	Fbxl6 / 30840	MGIID:	1354705	Length:	535	Species:	Mus musculus

Alignment Length:	503	Identity:	116/503 - (23%)
Similarity:	185/503 - (36%)	Gaps:	159/503 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 EKLPDKVLLHIFSYL--SHRE---ICRLARICRRWRQIAYDTRLWKNVSLRPEVSGLHVGS---- 90
            :::|.:||:|||..|  :|..   :.|.||:||.|.:......||..|:|.|.:.| ..|.
Mouse   105 DRIPLEVLVHIFGLLVAAHGPMPFLGRAARVCRHWHEATSHPSLWHTVTLSPSLVG-RAGKGNLK 168

  Fly    91 -----LEMLLQLISVRFGPTLRYIELPIELITHTVLHELSAKCPNLTHM-LLDFST--------- 140
                 |..|..|:..||........:..:...|:||..:|..||.||.: |.|..|
Mouse   169 GEKKLLACLEWLVPNRFSQLQSLTLIHWKSQVHSVLELVSKFCPRLTFLKLSDCHTVTAETLVML 233

  Fly   141 ---AMQLHDFSEMQAFPTKLRYMCVCLSEVI-FME---GFMRKIY----------------NFIN 182
               ..|||...        |.:..|..:.|: |:|   ..|||::                |...
Mouse   234 ARACCQLHSLD--------LHHSMVESTAVVSFLEEAGSRMRKLWLTYSSQTTAILGALLDNCCP 290

  Fly   183 GLEVLHLIGTYEKCEEEEEEIYEVINVHKLKSATPNLRVINLYGINFIDD------SHIDAFSSN 241
            .|:||. :.|...|.....:    :.|..|:...|.|:|:.|..:.::..      .....|.|
Mouse   291 QLQVLQ-VSTGMNCNNTPLQ----LPVEALQKGCPQLQVLRLLNLIWLPKPCGRGVPQGPGFPS- 349

  Fly   242 CIQLECLAVNFCNKVTGSTLKTLIQRSKRLTCLLMNGTSLKSEFVMQAEWDKCAL--QELD---- 300
             ::..|||.:.||.|:...|..|:.||.:|..|.:.|.:..:...:      |.|  |||:
Mouse   350 -LEELCLAGSTCNFVSNEVLGRLLHRSPKLRMLDLRGCARVTPSGL------CHLPCQELEQLYL 407

  Fly   301 ---------ITATDLSTECLVDMLSR-----IPSLKFLSAGQINGFNDSVLKQWME--SGTT--- 346
                     ..|.|.|     .:|:|     :..|.|  :||  ||::..|:|.:.  |||.
Mouse   408 GLYGISDGLTLAKDGS-----PLLTRKWYHTLRELDF--SGQ--GFSEKDLEQALAVFSGTPGGL 463

  Fly   347 -RSLISLDLDSSDNISDEGLLKFIQRQGHQLSACCLSGMPHITDQLWMSILPLLGNCKIIVMGTA 410
             .:|.||:|..:             |......:..:||.|.:   |:::    |.:|:.:..|
Mouse   464 HPALCSLNLRGT-------------RVTPSTVSSVISGCPGL---LYLN----LESCRCLPRG-- 506

  Fly   411 EKLGVNIHVDQLMDTIASNCGNLERL-----ELRWDPDNLRFSDKSQK 453
                                  |:|:     |::|..:.|..|..|.|
Mouse   507 ----------------------LKRVYRGLEEVQWCLEQLLTSPPSAK 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FipoQ	NP_733291.1	F-box-like	34..80	CDD:289689	17/49 (35%)
		leucine-rich repeat	131..156	CDD:275381	8/37 (22%)
		leucine-rich repeat	157..175	CDD:275381	5/21 (24%)
		leucine-rich repeat	219..244	CDD:275381	5/30 (17%)
		leucine-rich repeat	245..270	CDD:275381	10/24 (42%)
		leucine-rich repeat	271..295	CDD:275381	3/23 (13%)
		leucine-rich repeat	296..320	CDD:275381	9/43 (21%)
		leucine-rich repeat	321..348	CDD:275381	11/32 (34%)
		leucine-rich repeat	349..375	CDD:275381	5/25 (20%)
		leucine-rich repeat	376..403	CDD:275381	5/26 (19%)
		leucine-rich repeat	405..432	CDD:275381	1/26 (4%)
Fbxl6	NP_038937.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	61..99
		F-box-like	105..155	CDD:289689	17/49 (35%)
		LRR 1	169..195		5/25 (20%)
		AMN1	171..390	CDD:187754	54/233 (23%)
		leucine-rich repeat	188..213	CDD:275381	5/24 (21%)
		LRR 2	196..221		9/24 (38%)
		leucine-rich repeat	214..239	CDD:275381	5/24 (21%)
		LRR 3	222..247		5/32 (16%)
		leucine-rich repeat	240..291	CDD:275381	11/58 (19%)
		LRR 4	273..299		4/26 (15%)
		leucine-rich repeat	292..321	CDD:275381	7/33 (21%)
		LRR 5	304..329		6/28 (21%)
		leucine-rich repeat	322..349	CDD:275381	4/26 (15%)
		LRR 6	330..357		4/28 (14%)
		AMN1	<349..500	CDD:187754	45/187 (24%)
		leucine-rich repeat	350..377	CDD:275381	10/26 (38%)
		LRR 7	360..385		9/24 (38%)
		leucine-rich repeat	378..401	CDD:275381	5/28 (18%)
		LRR 8	386..411		5/30 (17%)
		LRR 9	415..441		7/32 (22%)
		leucine-rich repeat	434..466	CDD:275381	11/35 (31%)
		leucine-rich repeat	467..491	CDD:275381	7/36 (19%)
		LRR 10	474..499		6/44 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843071
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740