DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FipoQ and Skp2

DIOPT Version :9

Sequence 1:	NP_733291.1	Gene:	FipoQ / 43475	FlyBaseID:	FBgn0039667	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_001099886.1	Gene:	Skp2 / 294790	RGDID:	1562456	Length:	423	Species:	Rattus norvegicus

Alignment Length:	349	Identity:	75/349 - (21%)
Similarity:	128/349 - (36%)	Gaps:	122/349 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RSPFADTTIEKLPDKVLLHIFSYLSHREICRLARICRRWRQIAYDTRLWKNVSLRPEVSGLHVGS 90
            |..|...:.:.|||::||.|||.|...|:.|::.:|:||.:::.|..||:::.|..:  .||...
  Rat    89 RENFPGVSWDSLPDELLLGIFSCLCLPELLRVSGVCKRWYRLSLDESLWQSLDLAGK--NLHPDV 151

  Fly    91 LEMLLQLISVRFGPTLRYIELPI----------------ELITHTVLHELSAKCPNLTHMLLDFS 139
            ...||....|.|.....::|.|:                .:|..:.||.:.::|..|.::.|:
  Rat   152 TVRLLSRGVVAFRCPRSFMEQPLGESFSSFRVQHMDLSNSVINVSNLHGILSECSKLQNLSLE-- 214

  Fly   140 TAMQLHDFSEMQAFPTKLRYMCVCLSEVIFMEGFMRKIYNFINGLEVLHLIGTYEKCEEEEEEIY 204
             .:||.|                                         .::.|..:.|
  Rat   215 -GLQLSD-----------------------------------------PIVTTLAQNE------- 230

  Fly   205 EVINVHKLKSATPNLRVINLYGINFIDDSHIDAFSSNCIQLECLAVNFC---------------- 253
                         ||..:||.|.:...:|.:....|:|.:|:.|.:::|
  Rat   231 -------------NLVRLNLCGCSGFSESAVATLLSSCSRLDELNLSWCFDFTEKHVQAAVAHLP 282

  Fly   254 ------------NKVTGSTLKTLIQRSKRLTCL-LMNGTSLKS----EFVMQAEWDKCALQELDI 301
                        ..:..:.|.|||:|...|..| |.:...||:    || .|..:    ||.|.:
  Rat   283 DTLTQLNLSGYRKNLQKTDLCTLIKRCPNLVRLDLSDSIMLKNDCFPEF-FQLNY----LQHLSL 342

  Fly   302 T-ATDLSTECLVDMLSRIPSLKFL 324
            : ..|:..|.|:: |..||:||.|
  Rat   343 SRCYDIIPETLLE-LGEIPTLKTL 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FipoQ	NP_733291.1	F-box-like	34..80	CDD:289689	17/45 (38%)
		leucine-rich repeat	131..156	CDD:275381	5/24 (21%)
		leucine-rich repeat	157..175	CDD:275381	0/17 (0%)
		leucine-rich repeat	219..244	CDD:275381	7/24 (29%)
		leucine-rich repeat	245..270	CDD:275381	8/52 (15%)
		leucine-rich repeat	271..295	CDD:275381	8/28 (29%)
		leucine-rich repeat	296..320	CDD:275381	8/24 (33%)
		leucine-rich repeat	321..348	CDD:275381	3/4 (75%)
		leucine-rich repeat	349..375	CDD:275381
		leucine-rich repeat	376..403	CDD:275381
		leucine-rich repeat	405..432	CDD:275381
Skp2	NP_001099886.1	F-box-like	97..142	CDD:289689	17/44 (39%)
		leucine-rich repeat	137..167	CDD:275381	8/31 (26%)
		leucine-rich repeat	183..207	CDD:275381	4/23 (17%)
		AMN1	193..>345	CDD:187754	38/220 (17%)
		leucine-rich repeat	208..231	CDD:275381	7/86 (8%)
		leucine-rich repeat	232..257	CDD:275381	7/24 (29%)
		leucine-rich repeat	258..283	CDD:275381	3/24 (13%)
		leucine-rich repeat	285..311	CDD:275381	5/25 (20%)
		leucine-rich repeat	312..336	CDD:275381	8/24 (33%)
		leucine-rich repeat	337..356	CDD:275381	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346591
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840