DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FipoQ and FBXL4

DIOPT Version :9

Sequence 1:	NP_733291.1	Gene:	FipoQ / 43475	FlyBaseID:	FBgn0039667	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_001265645.1	Gene:	FBXL4 / 26235	HGNCID:	13601	Length:	621	Species:	Homo sapiens

Alignment Length:	512	Identity:	102/512 - (19%)
Similarity:	179/512 - (34%)	Gaps:	172/512 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DISTDIWGQ--------LAVEASQVYLSDGTVRSPFADTTIEKLPDKVLLHIFSYLSHREICRLA 58
            ||..|.:.:        |..:.|...|.:|.....|     :|||.:::..|.::|:..::||||
Human   245 DIEDDAYAEKDGCGMDSLNKKFSSAVLGEGPNNGYF-----DKLPYELIQLILNHLTLPDLCRLA 304

  Fly    59 RICRRWRQIAYDTRLWKNVSLRPEVSGLHVGSLEMLLQLISVRFGPTLRYIELPIELITHTVLHE 123
            :.|:...|...|...:.:::|:|..:.|...|||.
Human   305 QTCKLLSQHCCDPLQYIHLNLQPYWAKLDDTSLEF------------------------------ 339

  Fly   124 LSAKCPNLTHMLLDFSTAMQLHDFSEMQAFPTKLRYMCVCLSEVIFMEGFMRKIYNFINGLEVLH 188
            |.::|..:..:.|.::..   ..|..:..|.   |::.||.||::.:|            |...|
Human   340 LQSRCTLVQWLNLSWTGN---RGFISVAGFS---RFLKVCGSELVRLE------------LSCSH 386

  Fly   189 LIGTYEKCEEEEEEIYEVINVHKLKSATPNLRVINLYGINFIDDSHIDAFSSNCIQLECLAVNFC 253
            .:.  |.|.|...|:            .|||:.:||               |:|.:|...|.|..
Human   387 FLN--ETCLEVISEM------------CPNLQALNL---------------SSCDKLPPQAFNHI 422

  Fly   254 NKVTGSTLKTLIQRSKRLTCLLMNGTSLKSEFVMQAEWDKCALQELDITATDLSTECLVDMLSRI 318
            .|:                                     |:|:.|.:..|.:....|:.:|:..
Human   423 AKL-------------------------------------CSLKRLVLYRTKVEQTALLSILNFC 450

  Fly   319 PSLKFLSAGQINGFNDSVLKQWMESGTTRSLISLDLDSSDNISDEGLLKFIQRQGHQLSACCLSG 383
            ..|:.||.|......|..:...|.....:.|.:|||....||::.|:.:.            .||
Human   451 SELQHLSLGSCVMIEDYDVIASMIGAKCKKLRTLDLWRCKNITENGIAEL------------ASG 503

  Fly   384 MPHITDQL---WMSILPLLGNC------------KIIVMGTAEKLGVNIHVDQLMDTIASNCGNL 433
            .| :.::|   |...|.....|            |:.:  ||.:...:..:|:|    |.||..|
Human   504 CP-LLEELDLGWCPTLQSSTGCFTRLAHQLPNLQKLFL--TANRSVCDTDIDEL----ACNCTRL 561

  Fly   434 ERLEL----RWDPDNLRFSDKSQKAIDILRVK-CLKLRCMVLSDGRYYETVKANFER 485
            ::|::    ...|.:||...:|.|.:.:|.|. |.::      |.|....:.|:|.:
Human   562 QQLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQI------DNRAVLELNASFPK 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FipoQ	NP_733291.1	F-box-like	34..80	CDD:289689	12/45 (27%)
		leucine-rich repeat	131..156	CDD:275381	3/24 (13%)
		leucine-rich repeat	157..175	CDD:275381	6/17 (35%)
		leucine-rich repeat	219..244	CDD:275381	5/24 (21%)
		leucine-rich repeat	245..270	CDD:275381	4/24 (17%)
		leucine-rich repeat	271..295	CDD:275381	0/23 (0%)
		leucine-rich repeat	296..320	CDD:275381	5/23 (22%)
		leucine-rich repeat	321..348	CDD:275381	6/26 (23%)
		leucine-rich repeat	349..375	CDD:275381	7/25 (28%)
		leucine-rich repeat	376..403	CDD:275381	7/41 (17%)
		leucine-rich repeat	405..432	CDD:275381	7/26 (27%)
FBXL4	NP_001265645.1	F-box-like	280..318	CDD:315592	13/42 (31%)
		leucine-rich repeat	295..317	CDD:275381	7/21 (33%)
		leucine-rich repeat	318..346	CDD:275381	8/57 (14%)
		leucine-rich repeat	347..376	CDD:275381	6/34 (18%)
		LRR 1	376..397		7/34 (21%)
		leucine-rich repeat	377..398	CDD:275381	6/34 (18%)
		AMN1	394..601	CDD:332986	58/295 (20%)
		LRR 2	402..421		8/33 (24%)
		leucine-rich repeat	403..427	CDD:275381	9/75 (12%)
		LRR 3	427..448		4/20 (20%)
		leucine-rich repeat	428..452	CDD:275381	5/23 (22%)
		LRR 4	452..474		5/21 (24%)
		leucine-rich repeat	453..480	CDD:275381	6/26 (23%)
		LRR 5	480..501		7/32 (22%)
		leucine-rich repeat	481..506	CDD:275381	10/37 (27%)
		LRR 6	504..524		4/20 (20%)
		leucine-rich repeat	507..534	CDD:275381	4/26 (15%)
		LRR 7	532..558		6/31 (19%)
		leucine-rich repeat	535..560	CDD:275381	8/30 (27%)
		LRR 8	559..583		5/23 (22%)
		leucine-rich repeat	561..586	CDD:275381	6/24 (25%)
		LRR 9	584..609		6/30 (20%)
		leucine-rich repeat	587..612	CDD:275381	7/30 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810