Protein Alignment FipoQ and FBXO33

DIOPT Version :9

• Sequence 1: NP_733291.1
• Gene: FipoQ / 43475
• FlyBaseID: FBgn0039667
• Length: 515
• Species: Drosophila melanogaster
• Sequence 2: NP_976046.1
• Gene: FBXO33 / 254170
• HGNCID: 19833
• Length: 555
• Species: Homo sapiens
• Alignment Length: 522
• Identity: 98/522 - (18%)
• Similarity: 198/522 - (37%)
• Gaps: 138/522 - (26%)

  Fly    37 LPDKVLLHIFSYLSHREICRLARICRRWRQIAYDTRLWKNVSLRPEVSGLHVGSLEMLLQLISVR 101
            ||.::::||||:|...:..|.:..|..||:..:...||..:.:...||......||.|::    :
Human    71 LPSELIVHIFSFLPAPDRLRASASCSHWRECLFYPALWPQLRICLRVSPAEQPRLEFLMR----K 131

  Fly   102 FGPTLRYIELPIELITHTVLHELSAKCPNLTHMLLDFSTAMQLHDFSEMQAFPTKLRY------- 159
            .|..:|  ||.:|....   :.||...|.      |...|.......|::|.....|:
Human   132 CGWFVR--ELRVEFAAE---NYLSGGGPG------DGGGADTGTGGEEVEALQLSARWLEVLRTY 185

  Fly   160 ----MCVCLSEVIFMEGFMRKIYNFINGLEVLH----LIGTY--------EKCEEEEEEIYEVI- 207
                :||.:|  |.....::| ::....:.||.    |..||        :|.::.::...|::
Human   186 LELVLCVLVS--IRNNRNLQK-FSLFGDISVLQQQGSLSNTYLSKVDPDGKKIKQIQQLFEEILS 247

  Fly   208 NVHKLK--SATPNLRVINLYGINFIDDS------HIDAFSSNC---------------IQLECLA 249
            |..:||  |....|.::....::.:.::      |:....:|.               :.|..||
Human   248 NSRQLKWLSCGFMLEIVTPTSLSSLSNAVANTMEHLSLLDNNIPGNSTLITAVELERFVNLHSLA 312

  Fly   250 VNFCNKVTGSTLKTLIQRS----KRLTCLLMNGTSLKSEFVMQAEWDKCALQE------------ 298
            ::||: .|....:.|...:    :||:.|:.|.:      ||....|.....|
Human   313 LDFCD-FTAEMARVLTDSNHVPLQRLSLLVHNVS------VMHKSLDNMPNDEHWKALSRKSTSF 370

  Fly   299 -LDITATDLSTECLVDMLSRIPSL--------KFLSAGQINGFNDSVLKQWMESGTTRSLISLDL 354
             :.|.|.|:.:|.::.:|.  ||:        .:::.  ::|....::.:..:...|..::..|:
Human   371 RVYIMAFDIKSEDMLKILK--PSIPLERIHFDSYITC--VSGAIVDLISRQYDKFLTHFILMNDV 431

  Fly   355 -------DSSDNISDEGLLKFIQRQGHQLSACCLSGMPHITDQLW----MSILPLLGNCKIIVMG 408
                   |.|||.:::.|:....| ..:||...:.|.     .:|    ::|..|.|:...::..
Human   432 IDTSGFPDLSDNRNEDPLVLLAWR-CTKLSLLAIHGY-----TVWAHNLIAIARLRGSDLKVLEV 490

  Fly   409 TAEKLGVN-----------IHVDQLMDTIASNCG-------NLERLELRWDPDNLRFSDKSQKAI 455
            |.|.:..:           :|  .|::.::...|       ::|.|.:..:|:...:.:....:.
Human   491 TEESIDFDQGELADQDVDPVH--NLIEQVSLGLGQPWHAVMDIESLSVFTEPNRHFYREMQSFSE 553

  Fly   456 DI 457
            ||
Human   554 DI 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FipoQ	NP_733291.1	F-box-like	34..80	CDD:289689	13/42 (31%)
		leucine-rich repeat	131..156	CDD:275381	4/24 (17%)
		leucine-rich repeat	157..175	CDD:275381	5/28 (18%)
		leucine-rich repeat	219..244	CDD:275381	3/45 (7%)
		leucine-rich repeat	245..270	CDD:275381	7/28 (25%)
		leucine-rich repeat	271..295	CDD:275381	6/23 (26%)
		leucine-rich repeat	296..320	CDD:275381	6/36 (17%)
		leucine-rich repeat	321..348	CDD:275381	2/34 (6%)
		leucine-rich repeat	349..375	CDD:275381	7/32 (22%)
		leucine-rich repeat	376..403	CDD:275381	7/30 (23%)
		leucine-rich repeat	405..432	CDD:275381	5/44 (11%)
FBXO33	NP_976046.1	F-box-like	69..116	CDD:289689	13/44 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR20933
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100