DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FipoQ and Fbxl5

DIOPT Version :9

Sequence 1:	NP_733291.1	Gene:	FipoQ / 43475	FlyBaseID:	FBgn0039667	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_001153435.1	Gene:	Fbxl5 / 242960	MGIID:	2152883	Length:	690	Species:	Mus musculus

Alignment Length:	471	Identity:	100/471 - (21%)
Similarity:	162/471 - (34%)	Gaps:	153/471 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IWGQLAVEASQV--YLSDGTVRSPFADTTIE---------KLPDKVLLHIFSYLSHREICRLARI 60
            :|.| |.|..:|  |..|..     |||..|         .||.:|:|.|||||:.:|:||.:::
Mouse   173 LWNQ-AEERQKVLKYSVDEK-----ADTEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQV 231

  Fly    61 CRRWRQIAYDTRLWKNVSLRPEVSGLHVGSLEMLLQLISVRF-------GPTLRYIELPIELITH 118
            ..:|.|:|....|||:                    |..|.:       ||.   .||..|....
Mouse   232 STKWSQLAKTGSLWKH--------------------LYPVHWARGDWYSGPA---TELDTEPDEE 273

  Fly   119 TVLHELSAKCPNLTHMLLDFSTAMQL----HDFSEMQAFPTKLRYMCVCLSEVIFMEGFMRKIYN 179
            .|.:.            .|.|.|.|.    .|..|.:....:...:.:...|...:.|.:..:..
Mouse   274 WVRNR------------KDESRAFQEWDEDADIDESEESAEESVAISIAQMEKRVLHGLIHNVLP 326

  Fly   180 FINGLEVLHLIGTYEKCEEEEEEIYEVINVHKLKSATPNLRVINLYGINFIDDSHIDAFS--SNC 242
            :: |..|..|:..|......:       .|.::....|||..::|...: |.||..|::|  ..|
Mouse   327 YV-GTSVKTLVLAYSSAVSSK-------MVRQILELCPNLEHLDLTQTD-ISDSAFDSWSWLGCC 382

  Fly   243 IQLECLAVNFCNKVTGSTLKTLIQRSKRLTCLLMNGTSLKSEFVMQA------EWDKCALQELDI 301
            ..|..|.::.|.|:|...|:.:   |:.|..|    ||.:|.|:..|      .|     ...||
Mouse   383 QSLRHLDLSGCEKITDMALEKI---SRALGVL----TSHQSGFLKSAGKAASTPW-----TSKDI 435

  Fly   302 TATDLST-ECLVDMLSRIPSLKFLSAGQINGFNDSVLKQ--WMESGTTRSLIS-----LDLDSSD 358
            |....:. .||.::..:             |..:.:..:  |.|..::.||.|     ||.:...
Mouse   436 TMPSTTQYACLHNLTDK-------------GIGEEIDNEHSWTEPVSSESLTSPYVWMLDAEDLA 487

  Fly   359 NISDEGLLKFIQRQGHQLSACCLSGMPHITDQLWMSILPLLGNCKIIVMGTAEKLGVNIHVDQLM 423
            :|.|.     ::.:...:.:.|                         ||.||...|.:
Mouse   488 DIEDA-----VEWRHRNVESLC-------------------------VMETASNFGCS------- 515

  Fly   424 DTIASNCGNLERLELR 439
               :|.|.:.:.:.||
Mouse   516 ---SSGCYSKDIVGLR 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FipoQ	NP_733291.1	F-box-like	34..80	CDD:289689	19/54 (35%)
		leucine-rich repeat	131..156	CDD:275381	6/28 (21%)
		leucine-rich repeat	157..175	CDD:275381	2/17 (12%)
		leucine-rich repeat	219..244	CDD:275381	8/26 (31%)
		leucine-rich repeat	245..270	CDD:275381	7/24 (29%)
		leucine-rich repeat	271..295	CDD:275381	8/29 (28%)
		leucine-rich repeat	296..320	CDD:275381	5/24 (21%)
		leucine-rich repeat	321..348	CDD:275381	3/28 (11%)
		leucine-rich repeat	349..375	CDD:275381	6/30 (20%)
		leucine-rich repeat	376..403	CDD:275381	1/26 (4%)
		leucine-rich repeat	405..432	CDD:275381	7/26 (27%)
Fbxl5	NP_001153435.1	Hemerythrin-like. /evidence=ECO:0000250	1..159
		Hr_FBXL5	7..160	CDD:213984
		F-box-like	205..249	CDD:289689	18/63 (29%)
		leucine-rich repeat	333..353	CDD:275381	3/26 (12%)
		AMN1	<340..>404	CDD:187754	17/71 (24%)
		LRR 1	340..364		4/30 (13%)
		leucine-rich repeat	358..384	CDD:275381	8/26 (31%)
		LRR 2	365..392		8/27 (30%)
		leucine-rich repeat	385..410	CDD:275381	8/27 (30%)
		LRR 3	393..418		10/31 (32%)
		leucine-rich repeat	411..499	CDD:275381	22/114 (19%)
		LRR 4	478..507		6/58 (10%)
		leucine-rich repeat	500..539	CDD:275381	10/64 (16%)
		leucine-rich repeat	540..571	CDD:275381
		leucine-rich repeat	573..626	CDD:275381
		LRR 5	575..606
		AMN1	<602..>653	CDD:187754
		LRR 6	607..634
		leucine-rich repeat	627..652	CDD:275381
		LRR 7	635..660
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843146
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930