DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FipoQ and Lrrc29

DIOPT Version :9

Sequence 1:	NP_733291.1	Gene:	FipoQ / 43475	FlyBaseID:	FBgn0039667	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_001355337.1	Gene:	Lrrc29 / 234684	MGIID:	2443262	Length:	621	Species:	Mus musculus

Alignment Length:	498	Identity:	100/498 - (20%)
Similarity:	180/498 - (36%)	Gaps:	140/498 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 SHREIC--RLARICRRWRQIAYD-TRLWKNVSLRPEVSGLHVGSLEMLLQLISVRFGPTLRYIEL 111
            :|...|  .|.|:...:..:::: :..|.::|  |:||.....|...||:.|..|.| |||.::|
Mouse   172 NHLSSCFPSLERLSLAYCHLSFELSPTWGSIS--PQVSSPSQLSFHNLLKFIKERAG-TLRALDL 233

  Fly   112 P--------------------IELITHTVLHELSAKC--------PNLTHMLLDFSTAMQLHDFS 148
            .                    .||..|: ..:||::.        |.||.  ||.|....|.| .
Mouse   234 SGTGLPPEALQALGQVTGLKLEELYLHS-CRDLSSEAVTILCRQQPGLTS--LDLSGCSDLTD-G 294

  Fly   149 EMQAFPTKLRYM---------------CVCLSEVIFMEGFMRKIYN-------FINGLEVLHLIG 191
            .:.|....||::               |..|       |.:|::.:       .::|.|:..::|
Mouse   295 ALLAVSRGLRHLRHLSLKKLQRLTDAGCAAL-------GALRELQSLDMAECCLVSGRELAQVLG 352

  Fly   192 TYEKCEEEEEEIYEVINVHKLKSAT---------PNLRVINLYGINFIDDSHIDAFSSNCIQLEC 247
            :..:.......: .:.....||.|:         |:|:|::|.....:.:..:.|..:..|.|..
Mouse   353 SVRRAPRALTSL-RLAYCSSLKDASVLSMIPALGPSLKVLDLSSCMALTNQTMQAICTYLIHLSV 416

  Fly   248 LAVNFCNKVTGSTLKTLIQRSKR--LTCLL-----------------MNGTSLKSEFVMQAEWDK 293
            |.:.:|.::....|..|.:.|..  |:..|                 ..|:||   .::|
Mouse   417 LRLAWCKELQDWGLLGLKEPSDEPVLSPQLHQKVDNEAPDPQEPSSEPQGSSL---LMLQ----- 473

  Fly   294 CALQELDITATDLSTECLVDMLSRIPSLKFLSAGQINGFNDSVLKQWMESGTTRSLISLDLDSSD 358
             ||||||:||....|:..:..:.:.|.|:.||...:..|.|:
Mouse   474 -ALQELDLTACSKLTDASLAKVLQFPQLRQLSLSLLPAFTDT----------------------- 514

  Fly   359 NISDEGLLKFIQRQGHQLSACCLSGMPHITDQLWMSILPLLGNCKIIVMGTAEKLGVNIHVDQLM 423
                 ||:. :.|....|....||...|::|:.|.....|....:.:.:.:..:|     .:|.:
Mouse   515 -----GLVA-VARGCPSLERLTLSHCSHLSDEGWAQAARLWPRLQHLNLSSCSQL-----TEQTL 568

  Fly   424 DTIASNCGNLERLELRWDPDNLRFSDKSQKAIDILRVKCLKLR 466
            |||...|..|..|::...| .:..:........:.:|.|::.|
Mouse   569 DTIGQACKQLRVLDVAMCP-GINMAAVRHFQAQLPQVTCIQSR 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FipoQ	NP_733291.1	F-box-like	34..80	CDD:289689	6/32 (19%)
		leucine-rich repeat	131..156	CDD:275381	8/24 (33%)
		leucine-rich repeat	157..175	CDD:275381	5/32 (16%)
		leucine-rich repeat	219..244	CDD:275381	4/24 (17%)
		leucine-rich repeat	245..270	CDD:275381	6/24 (25%)
		leucine-rich repeat	271..295	CDD:275381	6/40 (15%)
		leucine-rich repeat	296..320	CDD:275381	8/23 (35%)
		leucine-rich repeat	321..348	CDD:275381	5/26 (19%)
		leucine-rich repeat	349..375	CDD:275381	3/25 (12%)
		leucine-rich repeat	376..403	CDD:275381	7/26 (27%)
		leucine-rich repeat	405..432	CDD:275381	6/26 (23%)
Lrrc29	NP_001355337.1	F-box-like	3..38	CDD:372399
		leucine-rich repeat	70..83	CDD:275381
		LRR_RI	<118..360	CDD:393385	42/201 (21%)
		leucine-rich repeat	121..154	CDD:275381
		leucine-rich repeat	155..180	CDD:275381	2/7 (29%)
		leucine-rich repeat	181..227	CDD:275381	13/48 (27%)
		leucine-rich repeat	228..248	CDD:275381	3/19 (16%)
		AMN1	240..428	CDD:187754	35/199 (18%)
		leucine-rich repeat	254..277	CDD:275381	5/23 (22%)
		leucine-rich repeat	280..305	CDD:275381	9/27 (33%)
		leucine-rich repeat	306..360	CDD:275381	7/60 (12%)
		leucine-rich repeat	331..356	CDD:275381	3/24 (13%)
		leucine-rich repeat	361..387	CDD:275381	3/26 (12%)
		leucine-rich repeat	388..413	CDD:275381	4/24 (17%)
		leucine-rich repeat	414..474	CDD:275381	12/68 (18%)
		AMN1	<475..589	CDD:187754	33/148 (22%)
		leucine-rich repeat	475..525	CDD:275381	17/78 (22%)
		leucine-rich repeat	526..551	CDD:275381	7/24 (29%)
		leucine-rich repeat	552..577	CDD:275381	6/29 (21%)
		leucine-rich repeat	578..603	CDD:275381	3/25 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843078
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740