DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FipoQ and KDM2A

DIOPT Version :9

Sequence 1:	NP_733291.1	Gene:	FipoQ / 43475	FlyBaseID:	FBgn0039667	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_036440.1	Gene:	KDM2A / 22992	HGNCID:	13606	Length:	1162	Species:	Homo sapiens

Alignment Length:	347	Identity:	72/347 - (20%)
Similarity:	132/347 - (38%)	Gaps:	98/347 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 KVLLHIFSYLSHREICRLARICRRWRQIAYDTRLWKNVSLR------PE-VSGLHVGSLEMLLQL 97
            :|.:.:|.|||.||:|...|:|:.|.:...|.|||..:.|.      |: :||:      :..|.
Human   896 EVWMSVFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGI------IKRQP 954

  Fly    98 ISVRFGPTLRYIELPIELITHTVLHELSAKCPNLTHMLLDFSTAMQLHDFSEMQAFPTKLRYMCV 162
            :|         ::|....|:...|..|..:.|.|..:||...:      :|.:.|..|.   .|.
Human   955 VS---------LDLSWTNISKKQLTWLVNRLPGLKDLLLAGCS------WSAVSALSTS---SCP 1001

  Fly   163 CLSEVIFMEGFMRKIYNFINGLEVLHLIGTYEKCEEEEEEIYEVI----------NVHKLKSATP 217
            .|                 ..|::...:|.      ::.:|.:::          |..||:
Human  1002 LL-----------------RTLDLRWAVGI------KDPQIRDLLTPPADKPGQDNRSKLR---- 1039

  Fly   218 NLRVINLYGINFIDDSHIDAFSSNCIQLECLAVNFCNKVTGSTLKTLIQRSKRLTCLLMNGTSLK 282
            |:....|.|:: |.|:.:.....:...|..|.::.|:.:|.       |.|..||.:   |:|
Human  1040 NMTDFRLAGLD-ITDATLRLIIRHMPLLSRLDLSHCSHLTD-------QSSNLLTAV---GSS-- 1091

  Fly   283 SEFVMQAEWDKCALQELDITATDLSTECLVDMLSRIPSLKFLSAGQINGFNDSVLKQWMESGTTR 347
                     .:.:|.||::...:..|:..:..|.||.::..:   .:.|     .||........
Human  1092 ---------TRYSLTELNMAGCNKLTDQTLIYLRRIANVTLI---DLRG-----CKQITRKACEH 1139

  Fly   348 SLISLDLDSSDNISDEGLLKFI 369
            .:..|.::|...:|||.|::.|
Human  1140 FISDLSINSLYCLSDEKLIQKI 1161

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FipoQ	NP_733291.1	F-box-like	34..80	CDD:289689	15/39 (38%)
		leucine-rich repeat	131..156	CDD:275381	5/24 (21%)
		leucine-rich repeat	157..175	CDD:275381	2/17 (12%)
		leucine-rich repeat	219..244	CDD:275381	4/24 (17%)
		leucine-rich repeat	245..270	CDD:275381	6/24 (25%)
		leucine-rich repeat	271..295	CDD:275381	4/23 (17%)
		leucine-rich repeat	296..320	CDD:275381	7/23 (30%)
		leucine-rich repeat	321..348	CDD:275381	3/26 (12%)
		leucine-rich repeat	349..375	CDD:275381	7/21 (33%)
		leucine-rich repeat	376..403	CDD:275381
		leucine-rich repeat	405..432	CDD:275381
KDM2A	NP_036440.1	cupin_like	199..299	CDD:328732
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	367..389
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..557
		zf-CXXC	<576..609	CDD:251032
		PHD_KDM2A	619..675	CDD:277113
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	704..789
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	839..887
		F-box-like	896..934	CDD:315592	15/37 (41%)
		leucine-rich repeat	930..954	CDD:275381	5/29 (17%)
		AMN1	932..1138	CDD:332986	50/286 (17%)
		leucine-rich repeat	955..978	CDD:275381	5/31 (16%)
		LRR 1	961..982		5/20 (25%)
		leucine-rich repeat	979..1002	CDD:275381	7/31 (23%)
		LRR 2	984..1010		7/51 (14%)
		leucine-rich repeat	1003..1040	CDD:275381	7/63 (11%)
		leucine-rich repeat	1041..1065	CDD:275381	4/24 (17%)
		LRR 3	1048..1073		5/25 (20%)
		leucine-rich repeat	1066..1095	CDD:275381	10/49 (20%)
		LRR 4	1074..1103		11/49 (22%)
		leucine-rich repeat	1096..1120	CDD:275381	7/23 (30%)
		LRR 5	1104..1128		4/26 (15%)
		leucine-rich repeat	1121..1140	CDD:275381	3/26 (12%)
		LRR 6	1129..1156		6/26 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810