DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment FipoQ and FBXL13

DIOPT Version :9

Sequence 1:NP_733291.1 Gene:FipoQ / 43475 FlyBaseID:FBgn0039667 Length:515 Species:Drosophila melanogaster
Sequence 2:NP_001381423.1 Gene:FBXL13 / 222235 HGNCID:21658 Length:825 Species:Homo sapiens


Alignment Length:600 Identity:119/600 - (19%)
Similarity:213/600 - (35%) Gaps:181/600 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 ASQVYLSDGTVRSPFADTTIEKLPDKVLLHIFSYLSHREICRLARICRRWRQIAYDTRLW----- 74
            :|:|:|.|.|::     ..|..||::.:|.||.|||.:::....::...|..:.....||     
Human   231 SSEVFLVDETLK-----CDISLLPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDF 290

  Fly    75 ---KNVSLRPE---VSGLHVGSLEML----------------------LQLISVRFGPTLRYIEL 111
               |||.  |:   ||.|....|.:|                      ||.::|...||      
Human   291 SSVKNVI--PDKYIVSTLQRWRLNVLRLNFRGCLLRPKTFRSVSHCRNLQELNVSDCPT------ 347

  Fly   112 PIELITHTVLHELSAKCPNLTHMLLDFSTAMQLHDFSEMQAFPTKLRYMCVCLSEVIFMEGFMRK 176
                .|...:..:|..||.:                            :|:.||........||.
Human   348 ----FTDESMRHISEGCPGV----------------------------LCLNLSNTTITNRTMRL 380

  Fly   177 IYNFINGLEVLHLIGTYEKCEEEEEEIYEVINV----HKLKSATPNLRVINLYGINFIDDSHIDA 237
            :....:.|:.|.|  .|  |....::..:.:|:    ||       |..::|.|...|.......
Human   381 LPRHFHNLQNLSL--AY--CRRFTDKGLQYLNLGNGCHK-------LIYLDLSGCTQISVQGFRY 434

  Fly   238 FSSNCIQLECLAVNFCNKVTGSTLKTLIQRSKRLTCLLMNGTSLKSEFVMQAEWDKCALQEL--- 299
            .:::|..:..|.:|....:|.:.:|.|:::..|:|.|:..|....|:...:| ...|.|:::   
Human   435 IANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRA-LSACKLRKIRFE 498

  Fly   300 -DITATDLS----------------------TECLVDMLSRIPSLKFLSAGQINGFNDSVLKQWM 341
             :...||.|                      |:..:..||.:..|..|:........|..|||::
Human   499 GNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFL 563

  Fly   342 ESGTTRSLISLDLDSSDNISDEGLLKFIQRQGHQLSACCLSGMPHITDQLWMSILPLLGNCKIIV 406
            :...:..:..|:|.:...:||..::|..:|..: |:...|....|:|.|....|:.:.....|.:
Human   564 DGPASMRIRELNLSNCVRLSDASVMKLSERCPN-LNYLSLRNCEHLTAQGIGYIVNIFSLVSIDL 627

  Fly   407 MGT-AEKLGVNI----------------------------------HVD-----QLMDTI----A 427
            .|| ....|:|:                                  |:|     ||.|.|    |
Human   628 SGTDISNEGLNVLSRHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMIIKALA 692

  Fly   428 SNCGNLERLELRWDPDNLRFSDKSQKAIDILRVKCLKLR------CMVLSDGRYYETVKANFERA 486
            ..|.||..|.:...|   :.:|   .|:::|..||..|.      |::|:| :..|.::..   .
Human   693 IYCINLTSLSIAGCP---KITD---SAMEMLSAKCHYLHILDISGCVLLTD-QILEDLQIG---C 747

  Fly   487 DRITVVRTTTCCRVS 501
            .::.:::...|..:|
Human   748 KQLRILKMQYCTNIS 762

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FipoQNP_733291.1 F-box-like 34..80 CDD:289689 15/53 (28%)
leucine-rich repeat 131..156 CDD:275381 0/24 (0%)
leucine-rich repeat 157..175 CDD:275381 3/17 (18%)
leucine-rich repeat 219..244 CDD:275381 5/24 (21%)
leucine-rich repeat 245..270 CDD:275381 5/24 (21%)
leucine-rich repeat 271..295 CDD:275381 5/23 (22%)
leucine-rich repeat 296..320 CDD:275381 7/49 (14%)
leucine-rich repeat 321..348 CDD:275381 6/26 (23%)
leucine-rich repeat 349..375 CDD:275381 6/25 (24%)
leucine-rich repeat 376..403 CDD:275381 6/26 (23%)
leucine-rich repeat 405..432 CDD:275381 12/70 (17%)
FBXL13NP_001381423.1 Sfi1 <112..>224 CDD:400658
F-box-like 245..289 CDD:403981 12/43 (28%)
leucine-rich repeat 285..312 CDD:275381 8/28 (29%)
AMN1 312..497 CDD:187754 41/234 (18%)
leucine-rich repeat 313..336 CDD:275381 1/22 (5%)
leucine-rich repeat 337..362 CDD:275381 8/34 (24%)
leucine-rich repeat 363..387 CDD:275381 5/51 (10%)
leucine-rich repeat 388..406 CDD:275381 5/21 (24%)
leucine-rich repeat 416..441 CDD:275381 5/24 (21%)
leucine-rich repeat 442..491 CDD:275381 11/49 (22%)
leucine-rich repeat 468..490 CDD:275381 5/22 (23%)
leucine-rich repeat 492..515 CDD:275381 4/22 (18%)
leucine-rich repeat 518..542 CDD:275381 3/23 (13%)
AMN1 529..737 CDD:187754 46/214 (21%)
leucine-rich repeat 543..570 CDD:275381 6/26 (23%)
leucine-rich repeat 571..596 CDD:275381 6/24 (25%)
leucine-rich repeat 597..645 CDD:275381 11/47 (23%)
leucine-rich repeat 646..671 CDD:275381 0/24 (0%)
leucine-rich repeat 672..697 CDD:275381 8/24 (33%)
leucine-rich repeat 698..723 CDD:275381 8/30 (27%)
leucine-rich repeat 724..749 CDD:275381 5/28 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165153062
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1947
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D288255at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.750

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