DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FipoQ and FBXO39

DIOPT Version :9

Sequence 1:	NP_733291.1	Gene:	FipoQ / 43475	FlyBaseID:	FBgn0039667	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_694962.1	Gene:	FBXO39 / 162517	HGNCID:	28565	Length:	442	Species:	Homo sapiens

Alignment Length:	368	Identity:	81/368 - (22%)
Similarity:	132/368 - (35%)	Gaps:	142/368 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LPDKVLLHIFSYLSHREICRLARICRRWRQIAYDTRLWK----NVSLRPEVSGLHVGSLEMLLQL 97
            |||..|..:|.:|..|:..|.|.:||:|.|:.|...||:    ..|.||  |.:|...:|..:..
Human    19 LPDLCLCRVFWWLGDRDRSRAALVCRKWNQMMYSAELWRYRTITFSGRP--SRVHASEVESAVWY 81

  Fly    98 ISVRFGPTLRYIELPIELITHTVLHELSAKCPNLTHMLLDFSTAMQLHDFSEMQAFPTKLRYMCV 162
            :. :||   ||:|                      |:.:.|   |..::....:.|...:|.:..
Human    82 VK-KFG---RYLE----------------------HLEVKF---MNPYNAVLTKKFQVTMRGLLS 117

  Fly   163 CLSE---------VIFME------------GFMRKIYNFI----NGLEVLHLIG---TYEK-CE- 197
            |||:         :.::|            .|:..:..|:    ..|:.|:|.|   |.|: |:
Human   118 CLSKSNNRLKSLSIQYLELDRLVWRNSIRSSFISSLSFFLKKMGKRLDYLNLKGARLTVEQGCQI 182

  Fly   198 ------EEEEEIYEVINVH----------------KLKSATPNLRVINLYGINFIDDSHIDAFSS 240
                  ...|.:...:|:.                |..|...||..:||   |:
Human   183 LDSLSYMRNENVISELNIEDYFSHHLAVYNSPQFKKTMSTFHNLVSLNL---NY----------- 233

  Fly   241 NCIQLECLAVNFCNKVTGSTLKTLIQRSKRLTC-----------------LLMNGTSLKSEFVMQ 288
            |||..|.|. |.|.  ..|||:|:     .:.|                 |....|:||..|..:
Human   234 NCISDELLE-NLCE--NASTLRTI-----NIKCHVHDPHGQVIWGMSWAKLARQATNLKVNFFFE 290

  Fly   289 --AEWDKCA---LQELDITATDLST------EC-----LVDML 315
              .::::.|   |||:.|.:..|.:      :|     |:|:|
Human   291 RIMKYERLARILLQEIPIRSISLRSCYFSDPDCSMRPTLIDLL 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FipoQ	NP_733291.1	F-box-like	34..80	CDD:289689	17/46 (37%)
		leucine-rich repeat	131..156	CDD:275381	4/24 (17%)
		leucine-rich repeat	157..175	CDD:275381	6/38 (16%)
		leucine-rich repeat	219..244	CDD:275381	6/24 (25%)
		leucine-rich repeat	245..270	CDD:275381	8/24 (33%)
		leucine-rich repeat	271..295	CDD:275381	6/42 (14%)
		leucine-rich repeat	296..320	CDD:275381	9/31 (29%)
		leucine-rich repeat	321..348	CDD:275381
		leucine-rich repeat	349..375	CDD:275381
		leucine-rich repeat	376..403	CDD:275381
		leucine-rich repeat	405..432	CDD:275381
FBXO39	NP_694962.1	F-box-like	16..57	CDD:289689	15/37 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900