DRSC/TRiP Functional Genomics Resources

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Protein Alignment FipoQ and Fbxl14

DIOPT Version :9

Sequence 1:NP_733291.1 Gene:FipoQ / 43475 FlyBaseID:FBgn0039667 Length:515 Species:Drosophila melanogaster
Sequence 2:NP_598701.2 Gene:Fbxl14 / 101358 MGIID:2141676 Length:400 Species:Mus musculus


Alignment Length:452 Identity:99/452 - (21%)
Similarity:165/452 - (36%) Gaps:134/452 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 DTTIEKLPDKVLLHIFSYLSHREICRLARICRRWRQIAYDTRLWK-----------NVSLRPEVS 84
            :|.|..|..::|..||.||..|:..|.|::|..||..||...:|:           |.||.|.:.
Mouse     2 ETHISCLFPELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANPSLFPSLQ 66

  Fly    85 GLHVGSLEMLLQLISVRFGPTLRYIELPIELITHTVLHELSAKCPNLTHMLLDFSTAMQLHDFSE 149
            ...:    ..:|::|:|  .:|.|:   |:.:.:.....||. |.|||...|..:...::     
Mouse    67 ARGI----RRVQILSLR--RSLSYV---IQGMANIESLNLSG-CYNLTDNGLGHAFVQEI----- 116

  Fly   150 MQAFPTKLRYMCVCLSEVIFMEGFMRKIYNFINGLEVLHLIGTYEKCEEEEEEIYEVINVHKLKS 214
                 ..||.:.:.|.:.| .:..:.:|..::.|||||.|.|    |.       .:.|...|..
Mouse   117 -----GSLRALNLSLCKQI-TDSSLGRIAQYLKGLEVLELGG----CS-------NITNTGLLLI 164

  Fly   215 A--TPNLRVINLYGINFIDD---SHIDAF----SSNCIQLECLAVNFCNKVTGSTLKTLIQRSKR 270
            |  ...|:.:||.....:.|   .|:...    :..|:.||.|.:..|.|:|..:||.:   |:.
Mouse   165 AWGLQRLKSLNLRSCRHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHI---SRG 226

  Fly   271 LTCLLMNGTSLKSEFVMQAEWDKCALQELDITATDLSTECLVDMLSRIPSLKFLSAGQINGFNDS 335
            ||                                               .|:.|:.....|.:|:
Mouse   227 LT-----------------------------------------------GLRLLNLSFCGGISDA 244

  Fly   336 VLKQWMESGTTRSLISLDLDSSDNISDEGLL--------------KFIQRQGHQLSACCLSGMP- 385
            .|......|   ||.||:|.|.|||||.|::              .|..:.|.|..|....|:. 
Mouse   245 GLLHLSHMG---SLRSLNLRSCDNISDTGIMHLAMGSLRLSGLDVSFCDKVGDQSLAYIAQGLDG 306

  Fly   386 ---------HITDQLWMSILPLLGNCKIIVMGTAEKLGVNIHVDQLMDTIASNCGNLERLEL 438
                     ||:|.....::..:...:.:.:|...::     .|:.::.||.:...|..::|
Mouse   307 LKSLSLCSCHISDDGINRMVRQMHGLRTLNIGQCVRI-----TDKGLELIAEHLSQLTGIDL 363

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FipoQNP_733291.1 F-box-like 34..80 CDD:289689 18/56 (32%)
leucine-rich repeat 131..156 CDD:275381 3/24 (13%)
leucine-rich repeat 157..175 CDD:275381 4/17 (24%)
leucine-rich repeat 219..244 CDD:275381 6/31 (19%)
leucine-rich repeat 245..270 CDD:275381 9/24 (38%)
leucine-rich repeat 271..295 CDD:275381 2/23 (9%)
leucine-rich repeat 296..320 CDD:275381 0/23 (0%)
leucine-rich repeat 321..348 CDD:275381 6/26 (23%)
leucine-rich repeat 349..375 CDD:275381 13/39 (33%)
leucine-rich repeat 376..403 CDD:275381 5/36 (14%)
leucine-rich repeat 405..432 CDD:275381 4/26 (15%)
Fbxl14NP_598701.2 Required for down-regulation of SNAI1. /evidence=ECO:0000250 2..48 17/45 (38%)
F-box-like 5..46 CDD:403981 15/40 (38%)
AMN1 90..296 CDD:187754 60/281 (21%)
leucine-rich repeat 92..118 CDD:275381 7/36 (19%)
leucine-rich repeat 119..142 CDD:275381 5/23 (22%)
LRR 1 144..163 9/29 (31%)
leucine-rich repeat 145..170 CDD:275381 10/35 (29%)
LRR 2 170..191 5/20 (25%)
leucine-rich repeat 171..203 CDD:275381 6/31 (19%)
LRR 3 203..225 8/24 (33%)
leucine-rich repeat 204..229 CDD:275381 11/74 (15%)
AMN1 228..395 CDD:187754 33/191 (17%)
LRR 4 229..250 5/20 (25%)
leucine-rich repeat 230..254 CDD:275381 6/26 (23%)
LRR 5 254..275 12/20 (60%)
leucine-rich repeat 255..280 CDD:275381 11/24 (46%)
leucine-rich repeat 281..306 CDD:275381 5/24 (21%)
leucine-rich repeat 307..331 CDD:275381 3/23 (13%)
leucine-rich repeat 332..357 CDD:275381 4/29 (14%)
leucine-rich repeat 358..382 CDD:275381 2/6 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1947
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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