DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FipoQ and Fbxl13

DIOPT Version :9

Sequence 1:	NP_733291.1	Gene:	FipoQ / 43475	FlyBaseID:	FBgn0039667	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	XP_038962809.1	Gene:	Fbxl13 / 100125363	RGDID:	1642425	Length:	823	Species:	Rattus norvegicus

Alignment Length:	535	Identity:	123/535 - (22%)
Similarity:	205/535 - (38%)	Gaps:	139/535 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 IEKLPDKVLLHIFSYLSHREICRLARICRRWRQIAYDTRLW--------KNVSLRPEVSGLHVGS 90
            |..|||:.::.||.||:.:::...:::.|.|..:.....||        ||::.|..|:.|....
  Rat   242 ISVLPDQAVVQIFVYLTFKDLVSCSQVNRSWMSMIQRGSLWNSIDFSTVKNIADRCVVTTLQKWR 306

  Fly    91 LEML----------------------LQLISVRFGPTLRYIELPIELITHTVLHELSAKCPNLTH 133
            |.:|                      ||.::|...|:          .|...:..:|..||.:.:
  Rat   307 LNVLRLNFRGCVLRAKTLKSVSHCKNLQELNVSDCPS----------FTDESMRHISEGCPGVLY 361

  Fly   134 MLLDFST----AMQL-----HDFSEM-----QAFPTK-LRYM----------------CVCLSEV 167
            :.|..:|    .|:|     |:...:     :.|..| |:|:                |..:|
  Rat   362 LNLSNTTITNRTMRLLPRYFHNLQNLSLAYCRKFTDKGLQYLNLGNGCHKLIYLDLSGCTQIS-- 424

  Fly   168 IFMEGFMRKIYNFINGLEVLHLI-------------GTYEKCEEEEEEIYEVINVH------KLK 213
              ::|| |.|.|...|  ::||.             ...|||......:: :.:.|      |..
  Rat   425 --VQGF-RNIANSCTG--IMHLTINDMPTLTDNCVKVLVEKCPRISSVVF-IGSPHISDCAFKAL 483

  Fly   214 SATPNLRVINLYGINFIDDSHIDAFSSNCIQLECLAVNFCNKVTGSTLKTLIQRSKRLT------ 272
            ||. :|:.|...|...|.|:...:...|...:..:.:..|..:|.|:||:| ...|:||
  Rat   484 SAC-DLKKIRFEGNKRITDACFKSVDRNYPGISHIYMVDCKGLTDSSLKSL-SVLKQLTVLNLTN 546

  Fly   273 CLLMNGTSLKSEFVMQAEWDKCALQELDITATDLSTECLVDMLS-RIPSLKFLSAGQINGFNDSV 336
            |:.:....|:..|...|   ...|:||::....|..:..|..|| |.|:|.:|:........|..
  Rat   547 CVRIGDIGLRQFFDGPA---SVKLRELNLANCSLLGDTSVIRLSERCPNLHYLNLRNCEHLTDLA 608

  Fly   337 LKQWMESGTTRSLISLDLDSSDNISDEGLLKFIQRQGHQLSACCLSGMPHITDQLWMSILPLLGN 401
            ::.   ..:..||||:|| |...||:|||.  |..:..:|....||...:|||      ..:...
  Rat   609 IEY---IASMLSLISIDL-SGTLISNEGLA--ILSRHRKLREVSLSECVNITD------FGIRAF 661

  Fly   402 CKIIVMGTAEKLGVNI---HVDQLMDTIASNCGNLERLELRWDPDNLRFSDKSQKAIDILRVKCL 463
            ||..:  ..|.|.|:.   ..|.::.|||..|..:..|.:...|   :.:|   ..::||..:|.
  Rat   662 CKTSL--ALEHLDVSYCAQLTDDIIKTIAIFCTRITSLHIAGCP---KITD---GGMEILSARCH 718

  Fly   464 KLR------CMVLSD 472
            .|.      |:.|:|
  Rat   719 YLHILDISGCVQLTD 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FipoQ	NP_733291.1	F-box-like	34..80	CDD:289689	14/53 (26%)
		leucine-rich repeat	131..156	CDD:275381	6/38 (16%)
		leucine-rich repeat	157..175	CDD:275381	6/33 (18%)
		leucine-rich repeat	219..244	CDD:275381	6/24 (25%)
		leucine-rich repeat	245..270	CDD:275381	6/24 (25%)
		leucine-rich repeat	271..295	CDD:275381	6/29 (21%)
		leucine-rich repeat	296..320	CDD:275381	8/24 (33%)
		leucine-rich repeat	321..348	CDD:275381	3/26 (12%)
		leucine-rich repeat	349..375	CDD:275381	12/25 (48%)
		leucine-rich repeat	376..403	CDD:275381	6/26 (23%)
		leucine-rich repeat	405..432	CDD:275381	8/29 (28%)
Fbxl13	XP_038962809.1	Sfi1	<134..>214	CDD:400658
		F-box-like	242..286	CDD:403981	12/43 (28%)
		leucine-rich repeat	257..270	CDD:275381	1/12 (8%)
		leucine-rich repeat	282..308	CDD:275381	6/25 (24%)
		AMN1	308..477	CDD:187754	32/186 (17%)
		leucine-rich repeat	309..332	CDD:275381	1/22 (5%)
		leucine-rich repeat	333..358	CDD:275381	7/34 (21%)
		leucine-rich repeat	359..383	CDD:275381	4/23 (17%)
		leucine-rich repeat	384..402	CDD:275381	3/17 (18%)
		leucine-rich repeat	412..437	CDD:275381	7/29 (24%)
		leucine-rich repeat	438..463	CDD:275381	5/24 (21%)
		leucine-rich repeat	464..486	CDD:275381	3/22 (14%)
		leucine-rich repeat	488..513	CDD:275381	6/24 (25%)
		leucine-rich repeat	514..534	CDD:275381	6/20 (30%)
		AMN1	525..733	CDD:187754	62/231 (27%)
		leucine-rich repeat	539..563	CDD:275381	5/23 (22%)
		leucine-rich repeat	567..592	CDD:275381	8/24 (33%)
		leucine-rich repeat	593..617	CDD:275381	3/26 (12%)
		leucine-rich repeat	618..641	CDD:275381	12/25 (48%)
		leucine-rich repeat	642..667	CDD:275381	8/32 (25%)
		leucine-rich repeat	668..693	CDD:275381	8/24 (33%)
		leucine-rich repeat	694..719	CDD:275381	6/30 (20%)
		leucine-rich repeat	720..745	CDD:275381	4/14 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346667
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288255at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750