DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2006 and DTWD1

DIOPT Version :9

Sequence 1:	NP_001189310.1	Gene:	CG2006 / 43472	FlyBaseID:	FBgn0039664	Length:	327	Species:	Drosophila melanogaster
Sequence 2:	NP_001138427.1	Gene:	DTWD1 / 56986	HGNCID:	30926	Length:	304	Species:	Homo sapiens

Alignment Length:	302	Identity:	108/302 - (35%)
Similarity:	162/302 - (53%)	Gaps:	53/302 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PFVHMRIADHSALDTIE--GRHNCRLCNRSRKFFCYSCCVPVGELE-ELLPRLELPLQVDIIKHK 76
            |..::.:|....|...:  ||..|..|..||.|:||:|.|||..:. |.:|.::|||::|||||.
Human    35 PLQNLCLASQEVLQKAQQSGRSKCLKCGGSRMFYCYTCYVPVENVPIEQIPLVKLPLKIDIIKHP 99

  Fly    77 KEIDGKSSAVHAAVLAPAHVRIHTFPDIPDYRE-EAGVVLIFPSATALAVPQLFARNVQLQIGDN 140
            .|.||||:|:||.:|||..|.|:|:|.||:|.| :..|.||||...::::..: :.::|.:|.:|
Human   100 NETDGKSTAIHAKLLAPEFVNIYTYPCIPEYEEKDHEVALIFPGPQSISIKDI-SFHLQKRIQNN 163

  Fly   141 Y-GLPKGHHMGTMLRRRMDEVEVKELQEEVDEPETVRRTWTLDNLPVRRAVFIDSTWNQSRGIYA 204
            . |........:..|:|.:|.|..:|.:...:..|           :::.:||||||||:..|:.
Human   164 VRGKNDDPDKPSFKRKRTEEQEFCDLNDSKCKGTT-----------LKKIIFIDSTWNQTNKIFT 217

  Fly   205 DARVRGLRTVVLQNRLSQFWRHQRGSPRWYLATIEAIHQFLLEVHINAWGLNTAYRGLDNLEITA 269
            |.|::||..|.|:.|.:.|||||:|.|..:|:|||||:.||::.|.:.
Human   218 DERLQGLLQVELKTRKTCFWRHQKGKPDTFLSTIEAIYYFLVDYHTDI----------------- 265

  Fly   270 GFHQLAEPLTKTAASENVGREAPYNGQYDNLLFFFAHMYDLI 311
                |.|               .|.|||||||||::.||.||
Human   266 ----LKE---------------KYRGQYDNLLFFYSFMYQLI 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2006	NP_001189310.1	DTW	44..312	CDD:281875	99/271 (37%)
DTWD1	NP_001138427.1	DTW	66..289	CDD:397847	99/271 (37%)
DTWD1	NP_001138427.1	DXTW	206..209		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160006
Domainoid	1	1.000	160	1.000	Domainoid score	I4081
eggNOG	1	0.900	-	-		E1_KOG3795
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10633
Inparanoid	1	1.050	173	1.000	Inparanoid score	I4078
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54886
OrthoDB	1	1.010	-	-		D601886at33208
OrthoFinder	1	1.000	-	-		FOG0006376
OrthoInspector	1	1.000	-	-		oto91700
orthoMCL	1	0.900	-	-		OOG6_104689
Panther	1	1.100	-	-	LDO	PTHR15627
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3038
SonicParanoid	1	1.000	-	-		X5326
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800